STRINGSTRING
IGF1 IGF1 TNFRSF21 TNFRSF21 FADD FADD IGFBP2 IGFBP2 CD274 CD274 CD28 CD28 Il18 Il18 TGFBR2 TGFBR2 ENSFDAP00000002799 ENSFDAP00000002799 LGALS3 LGALS3 BLM BLM IL21 IL21 LMO1 LMO1 EFNB1 EFNB1 CD3E CD3E LOC104868984 LOC104868984 RC3H1 RC3H1 CD6 CD6 CBLB CBLB IL12A IL12A TYK2 TYK2 LOC104874398 LOC104874398 HES1 HES1 H920_15994 H920_15994 ENSFDAP00000022477 ENSFDAP00000022477 SH3RF1 SH3RF1 GLMN GLMN PTPRC PTPRC SLC7A1 SLC7A1 CD86 CD86 LEP LEP SFTPD SFTPD Dhps Dhps FOXJ1 FOXJ1 MARCHF7 MARCHF7 IL15 IL15 IL23A IL23A ANXA1 ANXA1 CARD11 CARD11 SOS1 SOS1 TFRC TFRC VSIG4 VSIG4 LOC104854203 LOC104854203 CD40LG CD40LG SELENOK SELENOK Rps3 Rps3 Slamf1 Slamf1 IL23R IL23R MAD1L1 MAD1L1 CCL19 CCL19 SOS2 SOS2 Vcam1 Vcam1 BTN1A1 BTN1A1 LOC104874226 LOC104874226 ZNHIT1 ZNHIT1 Nck1 Nck1 CD276 CD276 CLEC4G CLEC4G LOC104868980 LOC104868980 ADK ADK LRRC1 LRRC1 KITLG KITLG GPAM GPAM SPTA1 SPTA1 LRRC32 LRRC32 SDC4 SDC4 PDE5A PDE5A CARMIL2 CARMIL2 PPP3CA PPP3CA DLG5 DLG5 SHH SHH SASH3 SASH3 PTPN6 PTPN6 TNFSF18 TNFSF18 SYK SYK SCRIB SCRIB H920_09656 H920_09656 Stat5b Stat5b CD1D CD1D IL2 IL2 ZAP70 ZAP70 ZC3H12D ZC3H12D PRKAR1A PRKAR1A LOC104849006 LOC104849006 ENSFDAP00000014392 ENSFDAP00000014392 Bmi1 Bmi1 TRAF6 TRAF6 FOXP3 FOXP3 IRF1 IRF1 LAPTM5 LAPTM5 IGF2 IGF2 Pla2g2d Pla2g2d CORO1A CORO1A TNFSF4 TNFSF4 IL6ST IL6ST NCK2 NCK2 CD81 CD81 Lgals9 Lgals9 CRTAM CRTAM Pycard Pycard LOC104861383 LOC104861383 LOC104871568 LOC104871568 VTCN1 VTCN1 RAC2 RAC2 ARG2 ARG2 JAK2 JAK2 DNAJA3 DNAJA3 Il1b Il1b IDO1 IDO1 CTLA4 CTLA4 Ctnnb1 Ctnnb1 RIPK2 RIPK2 MAPK8IP1 MAPK8IP1 BMP4 BMP4 Zp3 Zp3 ZBTB7B ZBTB7B PRKCQ PRKCQ ENSFDAP00000020777 ENSFDAP00000020777 TGFB1 TGFB1 BCL6 BCL6 AGER AGER CCDC88B CCDC88B TNFRSF1B TNFRSF1B TMEM131L TMEM131L H920_05445 H920_05445 NCKAP1L NCKAP1L TWSG1 TWSG1 ARG1 ARG1 IHH IHH PAWR PAWR TNFRSF13C TNFRSF13C ITGAL ITGAL TSPAN32 TSPAN32 PELI1 PELI1 H920_12543 H920_12543 PRNP PRNP PLA2G2F PLA2G2F NDFIP1 NDFIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IGF1Insulin-like growth factor I. (158 aa)
TNFRSF21Tumor necrosis factor receptor superfamily member 21. (622 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
IGFBP2Insulin-like growth factor-binding protein 2. (217 aa)
CD274Programmed cell death 1 ligand 1. (322 aa)
CD28T-cell-specific surface glycoprotein CD28. (255 aa)
Il18Interleukin-18. (293 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (560 aa)
ENSFDAP00000002799annotation not available (144 aa)
LGALS3Galectin. (252 aa)
BLMBloom syndrome protein. (1348 aa)
IL21Interleukin 21. (155 aa)
LMO1LIM domain only 1. (149 aa)
EFNB1Ephrin-B1; Belongs to the ephrin family. (345 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (169 aa)
LOC104868984Lymphotactin. (113 aa)
RC3H1Roquin. (1133 aa)
CD6T-cell differentiation antigen CD6. (607 aa)
CBLBE3 ubiquitin-protein ligase CBL-B. (938 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (240 aa)
TYK2Tyrosine-protein kinase. (981 aa)
LOC104874398Cytoplasmic protein NCK1-like. (348 aa)
HES1Transcription factor HES-1. (278 aa)
H920_15994Tyrosine-protein kinase. (1024 aa)
ENSFDAP00000022477annotation not available (326 aa)
SH3RF1Putative E3 ubiquitin-protein ligase SH3RF1. (888 aa)
GLMNGlomulin. (600 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (1146 aa)
SLC7A1High affinity cationic amino acid transporter 1. (672 aa)
CD86T-lymphocyte activation antigen CD86. (317 aa)
LEPLeptin. (167 aa)
SFTPDPulmonary surfactant-associated protein D. (375 aa)
DhpsDeoxyhypusine synthase. (369 aa)
FOXJ1Forkhead box protein J1. (418 aa)
MARCHF7E3 ubiquitin-protein ligase MARCH7. (688 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (181 aa)
IL23AInterleukin-23 subunit alpha. (189 aa)
ANXA1Annexin A1. (346 aa)
CARD11Caspase recruitment domain-containing protein 11. (1154 aa)
SOS1Son of sevenless like protein 1. (1289 aa)
TFRCTransferrin receptor protein 1. (765 aa)
VSIG4V-set and immunoglobulin domain containing 4. (369 aa)
LOC104854203CD59 glycoprotein. (129 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
SELENOKSelenoprotein K. (93 aa)
Rps340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
Slamf1Signaling lymphocytic activation molecule. (323 aa)
IL23RInterleukin-12 receptor subunit beta-2. (633 aa)
MAD1L1Mitotic spindle assembly checkpoint protein MAD1. (717 aa)
CCL19C-C motif chemokine. (104 aa)
SOS2Son of sevenless like protein 2. (1310 aa)
Vcam1Vascular cell adhesion protein 1. (742 aa)
BTN1A1Butyrophilin subfamily 1 member A1. (416 aa)
LOC104874226HLA class II histocompatibility antigen, DQ alpha 1 chain; Belongs to the MHC class II family. (255 aa)
ZNHIT1Zinc finger HIT domain-containing protein 1. (154 aa)
Nck1Cytoplasmic protein. (377 aa)
CD276CD276 molecule. (317 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
LOC104868980Lymphotactin. (112 aa)
ADKAdenosine kinase. (336 aa)
LRRC1Leucine-rich repeat-containing protein 1. (471 aa)
KITLGKit ligand. (272 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
SPTA1Spectrin alpha chain, erythrocyte. (2398 aa)
LRRC32Guanylate cyclase. (663 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (202 aa)
PDE5APhosphodiesterase. (863 aa)
CARMIL2Leucine-rich repeat-containing protein 16C. (1327 aa)
PPP3CASerine/threonine-protein phosphatase. (501 aa)
DLG5Disks large like protein 5; Belongs to the MAGUK family. (1818 aa)
SHHSonic hedgehog protein. (244 aa)
SASH3SAM and SH3 domain-containing protein 3. (380 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
TNFSF18Tumor necrosis factor ligand superfamily member 18. (186 aa)
SYKTyrosine-protein kinase. (629 aa)
SCRIBScribble planar cell polarity protein. (1614 aa)
H920_09656Catenin beta-1. (83 aa)
Stat5bSignal transducer and activator of transcription 5B. (736 aa)
CD1DAntigen-presenting glycoprotein CD1d. (326 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
ZAP70Tyrosine-protein kinase. (576 aa)
ZC3H12DZinc finger CCCH-type containing 12D. (390 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (381 aa)
LOC104849006HLA class II histocompatibility antigen, DM beta chain. (263 aa)
ENSFDAP00000014392annotation not available (76 aa)
Bmi1Polycomb complex protein BMI-1. (326 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
FOXP3Forkhead box protein P3. (430 aa)
IRF1Interferon regulatory factor. (326 aa)
LAPTM5Lysosomal protein transmembrane 5. (262 aa)
IGF2Insulin-like growth factor II. (192 aa)
Pla2g2dPhospholipase A(2). (168 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (391 aa)
TNFSF4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (181 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
NCK2Cytoplasmic protein. (377 aa)
CD81Tetraspanin. (214 aa)
Lgals9Galectin. (339 aa)
CRTAMCytotoxic and regulatory T cell molecule. (391 aa)
PycardApoptosis-associated speck-like protein containing a CARD. (122 aa)
LOC104861383Galectin-7-like. (95 aa)
LOC104871568Phospholipase A(2). (94 aa)
VTCN1V-set domain-containing T-cell activation inhibitor 1. (282 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
ARG2Arginase. (354 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
DNAJA3DnaJ like protein subfamily A member 3, mitochondrial. (478 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (408 aa)
CTLA4Cytotoxic T-lymphocyte protein 4. (223 aa)
Ctnnb1Catenin beta-1. (781 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2. (482 aa)
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (563 aa)
BMP4Bone morphogenetic protein 4. (410 aa)
Zp3Zona pellucida glycoprotein 3. (427 aa)
ZBTB7BZinc finger and BTB domain-containing protein 7B. (539 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
ENSFDAP00000020777annotation not available (90 aa)
TGFB1Transforming growth factor beta-1. (333 aa)
BCL6B-cell lymphoma 6 protein. (688 aa)
AGERAdvanced glycosylation end product-specific receptor. (418 aa)
CCDC88BCoiled-coil domain containing 88B. (1471 aa)
TNFRSF1BTumor necrosis factor receptor superfamily member 1B. (450 aa)
TMEM131LTransmembrane protein 131-like. (1459 aa)
H920_05445C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (499 aa)
NCKAP1LNck-associated protein 1-like. (1133 aa)
TWSG1Twisted gastrulation protein like protein 1. (223 aa)
ARG1Arginase. (323 aa)
IHHIndian hedgehog signaling molecule. (370 aa)
PAWRPRKC apoptosis WT1 regulator protein. (231 aa)
TNFRSF13CTNF receptor superfamily member 13C. (177 aa)
ITGALIntegrin alpha-L; Belongs to the integrin alpha chain family. (1138 aa)
TSPAN32Tetraspanin-32; Belongs to the tetraspanin (TM4SF) family. (276 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
H920_12543Transmembrane glycoprotein NMB. (474 aa)
PRNPMajor prion protein; Belongs to the prion family. (236 aa)
PLA2G2FPhospholipase A(2). (213 aa)
NDFIP1NEDD4 family-interacting protein 1. (200 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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