STRINGSTRING
UBXN11 UBXN11 FBXW9 FBXW9 ENSFDAP00000022768 ENSFDAP00000022768 ENSFDAP00000022675 ENSFDAP00000022675 HSPB1 HSPB1 H920_03683 H920_03683 FAF1 FAF1 TAB2 TAB2 SIRT2 SIRT2 STAM STAM TOLLIP TOLLIP WDR92 WDR92 GGA2 GGA2 UBE2L6 UBE2L6 OPTN OPTN H920_15942 H920_15942 Nsfl1c Nsfl1c CXCR4 CXCR4 TSG101 TSG101 RNFT1 RNFT1 WDR48 WDR48 UCHL3 UCHL3 VPS36 VPS36 SMAD3 SMAD3 MARCHF7 MARCHF7 UBR5 UBR5 UEVLD UEVLD HGS HGS ENSFDAP00000006648 ENSFDAP00000006648 RNF185 RNF185 TOP2A TOP2A ADRM1 ADRM1 TOM1 TOM1 SPRTN SPRTN OTUB2 OTUB2 GGA3 GGA3 PLAA PLAA H920_13791 H920_13791 DDI2 DDI2 SMARCAD1 SMARCAD1 CKS2 CKS2 USP13 USP13 UBXN8 UBXN8 H920_07462 H920_07462 UBAP1 UBAP1 CUEDC2 CUEDC2 HDAC6 HDAC6 RNF8 RNF8 RBCK1 RBCK1 Rnf31 Rnf31 H920_05040 H920_05040 FBXO7 FBXO7 ENSFDAP00000011804 ENSFDAP00000011804 Nup62 Nup62 UBXN1 UBXN1 UBAP1L UBAP1L Ascc2 Ascc2 DNAJB2 DNAJB2 RAD23B RAD23B GGA1 GGA1 ILRUN ILRUN JARID2 JARID2 RNF19B RNF19B CKS1B CKS1B NEDD4 NEDD4 N4BP2L1 N4BP2L1 BIRC2 BIRC2 USP5 USP5 NPLOC4 NPLOC4 TAB3 TAB3 Tom1l1 Tom1l1 Mdm2 Mdm2 TEPSIN TEPSIN VPS28 VPS28 IKBKG IKBKG RAD23A RAD23A SHARPIN SHARPIN Amfr Amfr UBXN2A UBXN2A FAF2 FAF2 CUEDC1 CUEDC1 UBXN2B UBXN2B TRIM32 TRIM32 NBR1 NBR1 RNF168 RNF168 TNFAIP3 TNFAIP3 Usp16 Usp16 TOM1L2 TOM1L2 ARMC9 ARMC9 AUP1 AUP1 UCHL1 UCHL1 ENSFDAP00000017776 ENSFDAP00000017776 SQSTM1 SQSTM1 Bub3 Bub3 OTUB1 OTUB1 RAE1 RAE1 N4BP1 N4BP1 FBXW7 FBXW7 TP53INP2 TP53INP2 STAM2 STAM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UBXN11UBX domain-containing protein 11. (466 aa)
FBXW9F-box/WD repeat-containing protein 9. (444 aa)
ENSFDAP00000022768annotation not available (265 aa)
ENSFDAP00000022675annotation not available (259 aa)
HSPB1Heat shock protein beta-1; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (186 aa)
H920_03683TOM1-like protein 1. (209 aa)
FAF1Phosphoglycerate kinase. (650 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (352 aa)
STAMSignal transducing adapter molecule 1. (542 aa)
TOLLIPToll interacting protein. (270 aa)
WDR92WD repeat-containing protein 92. (357 aa)
GGA2ADP-ribosylation factor-binding protein GGA2. (629 aa)
UBE2L6Ubiquitin/ISG15-conjugating enzyme E2 L6. (153 aa)
OPTNOptineurin. (599 aa)
H920_15942Activating signal cointegrator 1 complex subunit 2. (752 aa)
Nsfl1cNSFL1 cofactor p47. (372 aa)
CXCR4C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
TSG101Tumor susceptibility gene 101 protein. (391 aa)
RNFT1RING finger and transmembrane domain-containing protein 1. (399 aa)
WDR48WD repeat-containing protein 48. (677 aa)
UCHL3Ubiquitin C-terminal hydrolase L3. (222 aa)
VPS36Vacuolar protein-sorting-associated protein 36. (353 aa)
SMAD3Mothers against decapentaplegic homolog. (429 aa)
MARCHF7E3 ubiquitin-protein ligase MARCH7. (688 aa)
UBR5E3 ubiquitin-protein ligase UBR5. (2791 aa)
UEVLDUbiquitin-conjugating enzyme E2 variant 3. (469 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate. (778 aa)
ENSFDAP00000006648annotation not available (129 aa)
RNF185RING finger protein 185. (192 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1528 aa)
ADRM1Proteasomal ubiquitin receptor ADRM1. (407 aa)
TOM1Target of Myb protein 1. (492 aa)
SPRTNUncharacterized protein. (496 aa)
OTUB2Ubiquitin thioesterase OTUB2. (234 aa)
GGA3ADP-ribosylation factor-binding protein GGA3. (726 aa)
PLAAPhospholipase A-2-activating protein. (787 aa)
H920_13791Uncharacterized protein. (176 aa)
DDI2Regulator of solute carriers 1. (348 aa)
SMARCAD1annotation not available (1025 aa)
CKS2CDC28 protein kinase regulatory subunit 2. (79 aa)
USP13Ubiquitinyl hydrolase 1. (794 aa)
UBXN8UBX domain protein 8. (276 aa)
H920_07462Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
UBAP1Ubiquitin-associated protein 1. (501 aa)
CUEDC2CUE domain-containing protein 2. (279 aa)
HDAC6Histone deacetylase 6. (1108 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (449 aa)
RBCK1RanBP-type and C3HC4-type zinc finger-containing protein 1. (510 aa)
Rnf31RING finger protein 31. (1069 aa)
H920_05040Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (97 aa)
FBXO7F-box only protein 7. (477 aa)
ENSFDAP00000011804annotation not available (202 aa)
Nup62Nucleoporin 62. (40 aa)
UBXN1UBX domain-containing protein 1. (283 aa)
UBAP1LUbiquitin-associated protein 1. (362 aa)
Ascc2Activating signal cointegrator 1 complex subunit 2. (757 aa)
DNAJB2DnaJ like protein subfamily B member 2. (321 aa)
RAD23BUV excision repair protein RAD23 like protein B. (396 aa)
GGA1ADP-ribosylation factor-binding protein GGA1. (618 aa)
ILRUNN_BRCA1_IG domain-containing protein. (238 aa)
JARID2Protein Jumonji. (1246 aa)
RNF19BRBR-type E3 ubiquitin transferase. (521 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
NEDD4E3 ubiquitin-protein ligase. (837 aa)
N4BP2L1NEDD4-binding protein 2-like 1. (195 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (618 aa)
USP5Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (858 aa)
NPLOC4Fanconi anemia-associated protein of 100 kDa. (607 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (717 aa)
Tom1l1Target of myb1 like 1 membrane trafficking protein. (228 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2. (504 aa)
TEPSINENTH domain-containing protein. (548 aa)
VPS28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (221 aa)
IKBKGNF-kappa-B essential modulator. (417 aa)
RAD23AUV excision repair protein RAD23 like protein A. (362 aa)
SHARPINSharpin. (414 aa)
AmfrAutocrine motility factor receptor. (98 aa)
UBXN2AUBX domain protein 2A. (258 aa)
FAF2FAS-associated factor 2. (445 aa)
CUEDC1CUE domain-containing protein 1. (350 aa)
UBXN2BUBX domain-containing protein 2B. (330 aa)
TRIM32E3 ubiquitin-protein ligase TRIM32. (653 aa)
NBR1Next to BRCA1 gene 1 protein. (986 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (559 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (755 aa)
Usp16Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. (827 aa)
TOM1L2TOM1-like protein 2; Belongs to the TOM1 family. (528 aa)
ARMC9LisH domain-containing protein ARMC9. (605 aa)
AUP1AUP1 lipid droplet regulating VLDL assembly factor. (439 aa)
UCHL1Ubiquitin carboxyl-terminal hydrolase isozyme L1. (212 aa)
ENSFDAP00000017776annotation not available (72 aa)
SQSTM1Sequestosome-1. (400 aa)
Bub3Mitotic checkpoint protein BUB3. (326 aa)
OTUB1Ubiquitin thioesterase. (271 aa)
RAE1mRNA export factor. (368 aa)
N4BP1NEDD4-binding protein 1. (825 aa)
FBXW7F-box/WD repeat-containing protein 7. (708 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (188 aa)
STAM2Signal transducing adapter molecule 2. (524 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.