(19 nodes) Autophagy of nucleus network (Fukomys damarensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RB1CC1	RB1-inducible coiled-coil protein 1. (1592 aa)
	ENSFDAP00000017826	annotation not available (133 aa)
	ULK2	Serine/threonine-protein kinase ULK2. (1057 aa)
	ATG9B	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (852 aa)
	Atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (198 aa)
	Atg9a	Autophagy-related protein 9A. (839 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (699 aa)
	ATG3	Autophagy-related protein 3. (313 aa)
	ATG13	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
	ENSFDAP00000007466	annotation not available (44 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (141 aa)
	ATG2B	Autophagy-related protein 2 like protein B. (2063 aa)
	ENSFDAP00000002122	annotation not available (80 aa)
	WIPI2	WD repeat domain phosphoinositide-interacting protein 2. (418 aa)
	Wdr45	WD repeat domain phosphoinositide-interacting protein 4. (360 aa)
	WDR45B	WD repeat domain phosphoinositide-interacting protein 3. (344 aa)
	WIPI1	WD repeat domain phosphoinositide-interacting protein 1. (419 aa)
	ULK1	Serine/threonine-protein kinase ULK1. (1043 aa)
	ATG2A	Autophagy-related protein 2 like protein A. (1915 aa)

Your Current Organism:

Fukomys damarensis

NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG13	ENSFDAP00000006620	ENSFDAP00000000385	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	0.701
ATG12	ATG2A	ENSFDAP00000006620	ENSFDAP00000021153	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 2 like protein A.	0.539
ATG12	ATG2B	ENSFDAP00000006620	ENSFDAP00000004622	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 2 like protein B.	0.539
ATG12	ATG3	ENSFDAP00000006620	ENSFDAP00000001443	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 3.	0.995
ATG12	ATG7	ENSFDAP00000006620	ENSFDAP00000008688	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.999
ATG12	ATG9B	ENSFDAP00000006620	ENSFDAP00000015615	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.709
ATG12	Atg5	ENSFDAP00000006620	ENSFDAP00000013584	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.994
ATG12	Atg9a	ENSFDAP00000006620	ENSFDAP00000011724	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 9A.	0.772
ATG12	ENSFDAP00000002122	ENSFDAP00000006620	ENSFDAP00000002122	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	annotation not available	0.995
ATG12	ENSFDAP00000007466	ENSFDAP00000006620	ENSFDAP00000007466	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	annotation not available	0.994
ATG12	ENSFDAP00000017826	ENSFDAP00000006620	ENSFDAP00000017826	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	annotation not available	0.994
ATG12	RB1CC1	ENSFDAP00000006620	ENSFDAP00000021826	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	RB1-inducible coiled-coil protein 1.	0.772
ATG12	ULK1	ENSFDAP00000006620	ENSFDAP00000019802	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Serine/threonine-protein kinase ULK1.	0.970
ATG12	ULK2	ENSFDAP00000006620	ENSFDAP00000016191	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Serine/threonine-protein kinase ULK2.	0.961
ATG12	WDR45B	ENSFDAP00000006620	ENSFDAP00000004603	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	WD repeat domain phosphoinositide-interacting protein 3.	0.457
ATG12	WIPI1	ENSFDAP00000006620	ENSFDAP00000019633	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	WD repeat domain phosphoinositide-interacting protein 1.	0.946
ATG12	WIPI2	ENSFDAP00000006620	ENSFDAP00000002922	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	WD repeat domain phosphoinositide-interacting protein 2.	0.955
ATG12	Wdr45	ENSFDAP00000006620	ENSFDAP00000003603	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	WD repeat domain phosphoinositide-interacting protein 4.	0.457
ATG13	ATG12	ENSFDAP00000000385	ENSFDAP00000006620	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.701
ATG13	ATG2A	ENSFDAP00000000385	ENSFDAP00000021153	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	Autophagy-related protein 2 like protein A.	0.528