(39 nodes) T cell selection network (Fukomys damarensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD3D	T-cell surface glycoprotein CD3 delta chain. (166 aa)
	PTPRC	Receptor-type tyrosine-protein phosphatase C. (1146 aa)
	SRF	Serum response factor. (337 aa)
	BATF	Basic leucine zipper transcriptional factor ATF-like. (125 aa)
	OTUD5	OTU domain-containing protein 5. (370 aa)
	ITPKB	Kinase; Belongs to the inositol phosphokinase (IPK) family. (800 aa)
	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (951 aa)
	STAT6	Signal transducer and activator of transcription. (839 aa)
	TBX21	T-box transcription factor TBX21. (435 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3. (442 aa)
	ENSFDAP00000017826	annotation not available (133 aa)
	STAT3	Signal transducer and activator of transcription. (758 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2551 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1106 aa)
	AIRE	Autoimmune regulator. (471 aa)
	ZAP70	Tyrosine-protein kinase. (576 aa)
	CTSV	Cathepsin L1; Belongs to the peptidase C1 family. (334 aa)
	CD1D	Antigen-presenting glycoprotein CD1d. (326 aa)
	Atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (198 aa)
	MINK1	Misshapen-like kinase 1. (1345 aa)
	SYK	Tyrosine-protein kinase. (629 aa)
	SHH	Sonic hedgehog protein. (244 aa)
	GLI3	Transcriptional activator GLI3. (1570 aa)
	ENSFDAP00000010563	annotation not available (202 aa)
	CD3G	CD3g molecule. (182 aa)
	TOX	Thymocyte selection-associated high mobility group box protein TOX. (518 aa)
	IRF4	Interferon regulatory factor 4. (379 aa)
	DOCK2	Dedicator of cytokinesis protein 2; Belongs to the DOCK family. (1830 aa)
	ENSFDAP00000007466	annotation not available (44 aa)
	CARD11	Caspase recruitment domain-containing protein 11. (1154 aa)
	CCR7	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (181 aa)
	HLA-DMA	HLA class II histocompatibility antigen, DM alpha chain; Belongs to the MHC class II family. (304 aa)
	H920_06580	HLA class II histocompatibility antigen gamma chain. (148 aa)
	Fas	Tumor necrosis factor receptor superfamily member 6. (290 aa)
	STK11	Serine/threonine-protein kinase 11; Belongs to the protein kinase superfamily. (434 aa)
	CD3E	T-cell surface glycoprotein CD3 epsilon chain. (169 aa)
	CD28	T-cell-specific surface glycoprotein CD28. (255 aa)
	BRAF	Serine/threonine-protein kinase B-raf. (740 aa)

Your Current Organism:

Fukomys damarensis

NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIRE	TOX	ENSFDAP00000014446	ENSFDAP00000009272	Autoimmune regulator.	Thymocyte selection-associated high mobility group box protein TOX.	0.568
Atg5	ENSFDAP00000017826	ENSFDAP00000013584	ENSFDAP00000017826	Autophagy protein 5; Involved in autophagic vesicle formation.	annotation not available	0.895
Atg5	MTOR	ENSFDAP00000013584	ENSFDAP00000016649	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.418
BATF	CD3D	ENSFDAP00000021310	ENSFDAP00000002903	Basic leucine zipper transcriptional factor ATF-like.	T-cell surface glycoprotein CD3 delta chain.	0.416
BATF	GATA3	ENSFDAP00000021310	ENSFDAP00000017832	Basic leucine zipper transcriptional factor ATF-like.	Trans-acting T-cell-specific transcription factor GATA-3.	0.482
BATF	IRF4	ENSFDAP00000021310	ENSFDAP00000008536	Basic leucine zipper transcriptional factor ATF-like.	Interferon regulatory factor 4.	0.748
BATF	STAT3	ENSFDAP00000021310	ENSFDAP00000017259	Basic leucine zipper transcriptional factor ATF-like.	Signal transducer and activator of transcription.	0.624
BATF	STAT6	ENSFDAP00000021310	ENSFDAP00000020172	Basic leucine zipper transcriptional factor ATF-like.	Signal transducer and activator of transcription.	0.470
BRAF	CYLD	ENSFDAP00000001049	ENSFDAP00000020384	Serine/threonine-protein kinase B-raf.	Ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family.	0.402
BRAF	MTOR	ENSFDAP00000001049	ENSFDAP00000016649	Serine/threonine-protein kinase B-raf.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.492
BRAF	STAT3	ENSFDAP00000001049	ENSFDAP00000017259	Serine/threonine-protein kinase B-raf.	Signal transducer and activator of transcription.	0.636
BRAF	STAT6	ENSFDAP00000001049	ENSFDAP00000020172	Serine/threonine-protein kinase B-raf.	Signal transducer and activator of transcription.	0.426
CARD11	CD28	ENSFDAP00000006402	ENSFDAP00000002301	Caspase recruitment domain-containing protein 11.	T-cell-specific surface glycoprotein CD28.	0.548
CARD11	SYK	ENSFDAP00000006402	ENSFDAP00000012634	Caspase recruitment domain-containing protein 11.	Tyrosine-protein kinase.	0.702
CARD11	ZAP70	ENSFDAP00000006402	ENSFDAP00000013824	Caspase recruitment domain-containing protein 11.	Tyrosine-protein kinase.	0.647
CCR7	CD28	ENSFDAP00000006391	ENSFDAP00000002301	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	T-cell-specific surface glycoprotein CD28.	0.501
CCR7	CD3D	ENSFDAP00000006391	ENSFDAP00000002903	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	T-cell surface glycoprotein CD3 delta chain.	0.497
CCR7	CD3E	ENSFDAP00000006391	ENSFDAP00000003687	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	T-cell surface glycoprotein CD3 epsilon chain.	0.530
CCR7	CD3G	ENSFDAP00000006391	ENSFDAP00000009856	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	CD3g molecule.	0.494
CCR7	PTPRC	ENSFDAP00000006391	ENSFDAP00000023155	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Receptor-type tyrosine-protein phosphatase C.	0.511