(44 nodes) Negative regulation of T cell differentiation network (Fukomys damarensis)

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	NFKBID	NF-kappa-B inhibitor delta. (327 aa)
	Znf397	Zinc finger protein 271. (577 aa)
	HLX	H2.0-like homeobox protein. (320 aa)
	HSPB1	Heat shock protein beta-1; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (186 aa)
	DTX1	Protein deltex-4. (510 aa)
	IHH	Indian hedgehog signaling molecule. (370 aa)
	TMEM131L	Transmembrane protein 131-like. (1459 aa)
	BCL6	B-cell lymphoma 6 protein. (688 aa)
	ENSFDAP00000020777	annotation not available (90 aa)
	ZBTB7B	Zinc finger and BTB domain-containing protein 7B. (539 aa)
	FGL2	Fibrinogen like 2. (356 aa)
	TBX21	T-box transcription factor TBX21. (435 aa)
	BMP4	Bone morphogenetic protein 4. (410 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (389 aa)
	LAG3	Lymphocyte activation gene 3 protein. (439 aa)
	CTLA4	Cytotoxic T-lymphocyte protein 4. (223 aa)
	LOC104847992	Suppressor of cytokine signaling 5. (495 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (103 aa)
	TNFSF4	Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (181 aa)
	IRF1	Interferon regulatory factor. (326 aa)
	FOXP3	Forkhead box protein P3. (430 aa)
	ENSFDAP00000014687	annotation not available (76 aa)
	ZC3H8	Zinc finger CCCH domain-containing protein 8. (306 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
	TNFSF18	Tumor necrosis factor ligand superfamily member 18. (186 aa)
	SHH	Sonic hedgehog protein. (244 aa)
	LOXL3	Lysyl oxidase like protein 3. (753 aa)
	IFNB1	Interferon beta. (187 aa)
	GLI3	Transcriptional activator GLI3. (1570 aa)
	ZNF16	Zinc finger protein 16. (682 aa)
	PRDX2	Peroxiredoxin-2. (198 aa)
	SMAD7	Mothers against decapentaplegic homolog. (229 aa)
	RUNX3	Runt-related transcription factor 3. (302 aa)
	CLEC4G	C-type lectin domain family 4 member G. (293 aa)
	Socs5	Suppressor of cytokine signaling 5. (536 aa)
	ZC3H12A	Ribonuclease ZC3H12A. (595 aa)
	ANXA1	Annexin A1. (346 aa)
	H920_06580	HLA class II histocompatibility antigen gamma chain. (148 aa)
	FOXJ1	Forkhead box protein J1. (418 aa)
	RC3H1	Roquin. (1133 aa)
	SOCS1	Suppressor of cytokine signaling 1. (193 aa)
	RC3H2	RING finger and CCCH-type zinc finger domain-containing protein 2. (1188 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (401 aa)
	H920_15994	Tyrosine-protein kinase. (1024 aa)

Your Current Organism:

Fukomys damarensis

NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	CTLA4	ENSFDAP00000021238	ENSFDAP00000019023	B-cell lymphoma 6 protein.	Cytotoxic T-lymphocyte protein 4.	0.443
BCL6	FOXP3	ENSFDAP00000021238	ENSFDAP00000015807	B-cell lymphoma 6 protein.	Forkhead box protein P3.	0.653
BCL6	H920_06580	ENSFDAP00000021238	ENSFDAP00000005688	B-cell lymphoma 6 protein.	HLA class II histocompatibility antigen gamma chain.	0.499
BCL6	TBX21	ENSFDAP00000021238	ENSFDAP00000019681	B-cell lymphoma 6 protein.	T-box transcription factor TBX21.	0.636
BMP4	ENSFDAP00000014687	ENSFDAP00000019587	ENSFDAP00000014687	Bone morphogenetic protein 4.	annotation not available	0.558
BMP4	IHH	ENSFDAP00000019587	ENSFDAP00000021923	Bone morphogenetic protein 4.	Indian hedgehog signaling molecule.	0.442
BMP4	RUNX1	ENSFDAP00000019587	ENSFDAP00000002615	Bone morphogenetic protein 4.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.516
BMP4	RUNX3	ENSFDAP00000019587	ENSFDAP00000009497	Bone morphogenetic protein 4.	Runt-related transcription factor 3.	0.516
BMP4	SHH	ENSFDAP00000019587	ENSFDAP00000011941	Bone morphogenetic protein 4.	Sonic hedgehog protein.	0.638
BMP4	SMAD7	ENSFDAP00000019587	ENSFDAP00000009760	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.789
BMP4	TBX21	ENSFDAP00000019587	ENSFDAP00000019681	Bone morphogenetic protein 4.	T-box transcription factor TBX21.	0.457
CLEC4G	LAG3	ENSFDAP00000009395	ENSFDAP00000019294	C-type lectin domain family 4 member G.	Lymphocyte activation gene 3 protein.	0.709
CTLA4	BCL6	ENSFDAP00000019023	ENSFDAP00000021238	Cytotoxic T-lymphocyte protein 4.	B-cell lymphoma 6 protein.	0.443
CTLA4	FOXP3	ENSFDAP00000019023	ENSFDAP00000015807	Cytotoxic T-lymphocyte protein 4.	Forkhead box protein P3.	0.739
CTLA4	H920_15994	ENSFDAP00000019023	ENSFDAP00000001901	Cytotoxic T-lymphocyte protein 4.	Tyrosine-protein kinase.	0.647
CTLA4	IL2	ENSFDAP00000019023	ENSFDAP00000013806	Cytotoxic T-lymphocyte protein 4.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.643
CTLA4	LAG3	ENSFDAP00000019023	ENSFDAP00000019294	Cytotoxic T-lymphocyte protein 4.	Lymphocyte activation gene 3 protein.	0.714
CTLA4	RUNX1	ENSFDAP00000019023	ENSFDAP00000002615	Cytotoxic T-lymphocyte protein 4.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.450
CTLA4	RUNX3	ENSFDAP00000019023	ENSFDAP00000009497	Cytotoxic T-lymphocyte protein 4.	Runt-related transcription factor 3.	0.450
CTLA4	TBX21	ENSFDAP00000019023	ENSFDAP00000019681	Cytotoxic T-lymphocyte protein 4.	T-box transcription factor TBX21.	0.433