STRINGSTRING
FUS FUS TFPT TFPT EGFR EGFR Babam1 Babam1 Brcc3 Brcc3 BRCA1 BRCA1 WDR48 WDR48 WAS WAS ENSFDAP00000004931 ENSFDAP00000004931 DTX3L DTX3L SHLD1 SHLD1 EPC2 EPC2 MFSD11 MFSD11 BCL7C BCL7C ENSFDAP00000006648 ENSFDAP00000006648 Rps3 Rps3 CCDC117 CCDC117 ZCWPW1 ZCWPW1 DMAP1 DMAP1 RAD51AP1 RAD51AP1 ENSFDAP00000008831 ENSFDAP00000008831 TIMELESS TIMELESS ENSFDAP00000008979 ENSFDAP00000008979 RIF1 RIF1 VPS72 VPS72 ENSFDAP00000009158 ENSFDAP00000009158 FH FH PARP3 PARP3 RBBP8 RBBP8 FGF10 FGF10 PARP1 PARP1 YEATS4 YEATS4 H920_07462 H920_07462 FOXM1 FOXM1 CBX8 CBX8 ENSFDAP00000002799 ENSFDAP00000002799 APBB1 APBB1 Yy1 Yy1 XRCC1 XRCC1 BLM BLM INO80D INO80D HELQ HELQ H920_12355 H920_12355 INO80C INO80C POGZ POGZ MGMT MGMT PARG PARG RNF8 RNF8 TRRAP TRRAP Actb Actb LOC104851526 LOC104851526 ACTR2 ACTR2 H920_12193 H920_12193 BABAM2 BABAM2 ACTL6A ACTL6A Ino80b Ino80b ARID2 ARID2 FANCB FANCB SHLD2 SHLD2 ENSFDAP00000014392 ENSFDAP00000014392 CEBPG CEBPG BRD8 BRD8 DDX11 DDX11 ACTR8 ACTR8 ING3 ING3 ACTR5 ACTR5 Spidr Spidr PRKCG PRKCG MMS19 MMS19 RUVBL2 RUVBL2 HDGFL2 HDGFL2 SPIRE1 SPIRE1 SLF1 SLF1 TIGAR TIGAR KDM4D KDM4D H920_10109 H920_10109 EPC1 EPC1 INO80 INO80 ENSFDAP00000017776 ENSFDAP00000017776 KMT5B KMT5B FAM178B FAM178B INO80E INO80E MORF4L1 MORF4L1 SIRT1 SIRT1 KAT5 KAT5 EYA2 EYA2 ENSFDAP00000019336 ENSFDAP00000019336 MEAF6 MEAF6 SIRT6 SIRT6 PRKDC PRKDC EYA4 EYA4 PCNA PCNA FAM168A FAM168A EP400 EP400 RUVBL1 RUVBL1 MAD2L2 MAD2L2 EYA3 EYA3 EYA1 EYA1 PIAS4 PIAS4 DHX9 DHX9 ENSFDAP00000001970 ENSFDAP00000001970 ENSFDAP00000002052 ENSFDAP00000002052 ENSFDAP00000002145 ENSFDAP00000002145 ABRAXAS1 ABRAXAS1 SMCHD1 SMCHD1 H920_04415 H920_04415 MBTD1 MBTD1 WRAP53 WRAP53 RNF168 RNF168 Mcrs1 Mcrs1 BCL7B BCL7B ENSFDAP00000020831 ENSFDAP00000020831 H920_00078 H920_00078 ENSFDAP00000021351 ENSFDAP00000021351 NFRKB NFRKB ENSFDAP00000021621 ENSFDAP00000021621 H920_06990 H920_06990 UBE2V2 UBE2V2 SLF2 SLF2 Trim28 Trim28 ERCC6 ERCC6 KMT5C KMT5C H920_01108 H920_01108 Uchl5 Uchl5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FUSRNA-binding protein FUS. (516 aa)
TFPTTCF3 fusion partner like protein. (252 aa)
EGFRReceptor protein-tyrosine kinase. (1168 aa)
Babam1BRISC and BRCA1 A complex member 1. (293 aa)
Brcc3Lys-63-specific deubiquitinase BRCC36. (288 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1737 aa)
WDR48WD repeat-containing protein 48. (677 aa)
WASWASP actin nucleation promoting factor. (420 aa)
ENSFDAP00000004931annotation not available (394 aa)
DTX3LE3 ubiquitin-protein ligase DTX3L. (738 aa)
SHLD1Shieldin complex subunit 1. (203 aa)
EPC2Enhancer of polycomb homolog. (804 aa)
MFSD11UNC93-like protein MFSD11. (449 aa)
BCL7CBAF chromatin remodeling complex subunit BCL7C. (147 aa)
ENSFDAP00000006648annotation not available (129 aa)
Rps340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
CCDC117Coiled-coil domain-containing protein 117. (223 aa)
ZCWPW1Zinc finger CW-type PWWP domain protein 1. (611 aa)
DMAP1DNA methyltransferase 1-associated protein 1. (468 aa)
RAD51AP1RAD51-associated protein 1. (335 aa)
ENSFDAP00000008831annotation not available (330 aa)
TIMELESSProtein timeless like protein. (1207 aa)
ENSFDAP00000008979annotation not available (180 aa)
RIF1Replication timing regulatory factor 1. (2455 aa)
VPS72Vacuolar protein sorting-associated protein 72 like protein. (364 aa)
ENSFDAP00000009158annotation not available (49 aa)
FHFumarate hydratase, mitochondrial. (508 aa)
PARP3Poly [ADP-ribose] polymerase. (531 aa)
RBBP8RB binding protein 8, endonuclease. (901 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (973 aa)
YEATS4YEATS domain-containing protein 4. (227 aa)
H920_07462Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
FOXM1Forkhead box protein M1. (763 aa)
CBX8Chromobox protein like protein 8. (365 aa)
ENSFDAP00000002799annotation not available (144 aa)
APBB1Amyloid beta A4 protein-binding family B member 1. (709 aa)
Yy1YY1 transcription factor. (189 aa)
XRCC1DNA repair protein XRCC1. (628 aa)
BLMBloom syndrome protein. (1348 aa)
INO80DINO80 complex subunit D. (1026 aa)
HELQHelicase POLQ-like. (987 aa)
H920_12355Bifunctional polynucleotide phosphatase/kinase. (173 aa)
INO80CINO80 complex subunit C. (192 aa)
POGZPogo transposable element with ZNF domain. (1413 aa)
MGMTMethylated-DNA--protein-cysteine methyltransferase. (209 aa)
PARGPoly(ADP-ribose) glycohydrolase. (967 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (449 aa)
TRRAPTransformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. (3838 aa)
ActbActin, cytoplasmic 1. (375 aa)
LOC104851526Histone-lysine N-methyltransferase SETMAR. (299 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
H920_12193Actin, cytoplasmic type 8; Belongs to the actin family. (187 aa)
BABAM2BRISC and BRCA1 A complex member 2. (409 aa)
ACTL6AActin-like protein 6A; Belongs to the actin family. (429 aa)
Ino80bINO80 complex subunit B. (349 aa)
ARID2AT-rich interactive domain-containing protein 2. (1765 aa)
FANCBFanconi anemia group B protein. (715 aa)
SHLD2Protein FAM35A. (888 aa)
ENSFDAP00000014392annotation not available (76 aa)
CEBPGCCAAT/enhancer-binding protein gamma. (150 aa)
BRD8Bromodomain-containing protein 8. (951 aa)
DDX11DEAD/H-box helicase 11. (772 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
ING3Inhibitor of growth protein. (418 aa)
ACTR5Actin related protein 5. (602 aa)
SpidrUncharacterized protein. (552 aa)
PRKCGProtein kinase C. (680 aa)
MMS19MMS19 nucleotide excision repair protein like protein. (1022 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
HDGFL2Hepatoma-derived growth factor-related protein 2. (556 aa)
SPIRE1Protein spire like protein 1. (713 aa)
SLF1Ankyrin repeat domain-containing protein 32. (1057 aa)
TIGARPutative fructose-2,6-bisphosphatase TIGAR. (234 aa)
KDM4DLysine-specific demethylase 4D. (523 aa)
H920_10109MRG domain-containing protein. (324 aa)
EPC1Enhancer of polycomb homolog. (813 aa)
INO80DNA helicase INO80. (1559 aa)
ENSFDAP00000017776annotation not available (72 aa)
KMT5BHistone-lysine N-methyltransferase SUV420H1. (883 aa)
FAM178BFamily with sequence similarity 178 member B. (513 aa)
INO80EINO80 complex subunit E. (243 aa)
MORF4L1MRG domain-containing protein. (348 aa)
SIRT1NAD-dependent deacetylase sirtuin-1. (603 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
EYA2EYA transcriptional coactivator and phosphatase 2. (500 aa)
ENSFDAP00000019336annotation not available (242 aa)
MEAF6MYST/Esa1 associated factor 6. (171 aa)
SIRT6NAD-dependent deacetylase sirtuin-6. (282 aa)
PRKDCDNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family. (4143 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (616 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
FAM168AProtein FAM168A. (257 aa)
EP400E1A-binding protein p400. (3036 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (572 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (591 aa)
PIAS4Protein inhibitor of activated STAT 4. (386 aa)
DHX9ATP-dependent RNA helicase A. (1368 aa)
ENSFDAP00000001970annotation not available (234 aa)
ENSFDAP00000002052annotation not available (317 aa)
ENSFDAP00000002145annotation not available (192 aa)
ABRAXAS1BRCA1-A complex subunit Abraxas. (359 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain-containing protein 1. (1920 aa)
H920_04415BRCA1-A complex subunit RAP80. (415 aa)
MBTD1MBT domain-containing protein 1. (647 aa)
WRAP53Telomerase Cajal body protein 1. (507 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (559 aa)
Mcrs1Microspherule protein 1. (462 aa)
BCL7BBAF chromatin remodeling complex subunit BCL7B. (176 aa)
ENSFDAP00000020831annotation not available (273 aa)
H920_00078Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (159 aa)
ENSFDAP00000021351annotation not available (285 aa)
NFRKBNuclear factor related to kappa-B-binding protein. (1299 aa)
ENSFDAP00000021621annotation not available (316 aa)
H920_06990Transcription intermediary factor 1-beta. (810 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
SLF2Protein FAM178A. (1168 aa)
Trim28Transcription intermediary factor 1-beta. (719 aa)
ERCC6DNA excision repair protein ERCC-6. (1446 aa)
KMT5CHistone-lysine N-methyltransferase SUV420H2. (377 aa)
H920_01108MRG-binding protein. (75 aa)
Uchl5Ubiquitin carboxyl-terminal hydrolase. (327 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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