(13 nodes) Otolith development network (Fukomys damarensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LRIG1	Leucine rich repeats and immunoglobulin like domains 1. (1007 aa)
	LRIG3	Leucine rich repeats and immunoglobulin like domains 3. (1050 aa)
	OTOL1	Otolin-1. (474 aa)
	ATG4B	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (391 aa)
	NOX3	NADPH oxidase 3. (568 aa)
	ENSFDAP00000007466	annotation not available (44 aa)
	H920_04768	Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). (82 aa)
	Oc90	Phospholipase A(2). (379 aa)
	Atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (198 aa)
	SLC44A4	Choline transporter-like protein 4; Belongs to the CTL (choline transporter-like) family. (557 aa)
	TTC39C	Tetratricopeptide repeat protein 39C. (527 aa)
	ENSFDAP00000017826	annotation not available (133 aa)
	ATP2B2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1242 aa)

Your Current Organism:

Fukomys damarensis

NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG4B	Atg5	ENSFDAP00000005553	ENSFDAP00000013584	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.606
ATG4B	ENSFDAP00000007466	ENSFDAP00000005553	ENSFDAP00000007466	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	annotation not available	0.606
ATG4B	ENSFDAP00000017826	ENSFDAP00000005553	ENSFDAP00000017826	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	annotation not available	0.606
Atg5	ATG4B	ENSFDAP00000013584	ENSFDAP00000005553	Autophagy protein 5; Involved in autophagic vesicle formation.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.606
Atg5	ENSFDAP00000017826	ENSFDAP00000013584	ENSFDAP00000017826	Autophagy protein 5; Involved in autophagic vesicle formation.	annotation not available	0.895
ENSFDAP00000007466	ATG4B	ENSFDAP00000007466	ENSFDAP00000005553	annotation not available	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.606
ENSFDAP00000017826	ATG4B	ENSFDAP00000017826	ENSFDAP00000005553	annotation not available	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.606
ENSFDAP00000017826	Atg5	ENSFDAP00000017826	ENSFDAP00000013584	annotation not available	Autophagy protein 5; Involved in autophagic vesicle formation.	0.895
LRIG1	LRIG3	ENSFDAP00000020763	ENSFDAP00000020123	Leucine rich repeats and immunoglobulin like domains 1.	Leucine rich repeats and immunoglobulin like domains 3.	0.666
LRIG3	LRIG1	ENSFDAP00000020123	ENSFDAP00000020763	Leucine rich repeats and immunoglobulin like domains 3.	Leucine rich repeats and immunoglobulin like domains 1.	0.666
OTOL1	Oc90	ENSFDAP00000001183	ENSFDAP00000009142	Otolin-1.	Phospholipase A(2).	0.566
Oc90	OTOL1	ENSFDAP00000009142	ENSFDAP00000001183	Phospholipase A(2).	Otolin-1.	0.566