STRINGSTRING
RICTOR RICTOR PDGFB PDGFB PTPRC PTPRC ERCC6 ERCC6 FBXW9 FBXW9 RELN RELN RASA1 RASA1 ABI1 ABI1 PDGFRA PDGFRA DVL2 DVL2 ACVR1 ACVR1 ITGB1 ITGB1 DGKQ DGKQ H920_05906 H920_05906 DLG3 DLG3 FCER1A FCER1A EPHA4 EPHA4 EFNA1 EFNA1 LYN LYN H920_09510 H920_09510 Il5 Il5 EPGN EPGN CLCF1 CLCF1 HAX1 HAX1 LRRK1 LRRK1 DLG4 DLG4 CSPG4 CSPG4 PARP14 PARP14 Arl2bp Arl2bp AFAP1L2 AFAP1L2 CNTN1 CNTN1 ADIPOQ ADIPOQ RIPK2 RIPK2 H920_19261 H920_19261 Tnfrsf18 Tnfrsf18 AGT AGT ICAM1 ICAM1 HGF HGF ITGA5 ITGA5 FGF8 FGF8 ADNP ADNP AGRN AGRN FGFR3 FGFR3 CSF2 CSF2 JAK2 JAK2 ISL1 ISL1 HTR2A HTR2A TGFA TGFA MTOR MTOR CD81 CD81 IL12B IL12B IL6ST IL6ST FBXW7 FBXW7 IGF2 IGF2 ERBB3 ERBB3 Itgb3 Itgb3 Alkal2 Alkal2 ALK ALK GREM1 GREM1 PTK2B PTK2B PTGER4 PTGER4 ALKAL1 ALKAL1 NOD2 NOD2 Vegfa Vegfa CRLF1 CRLF1 NEDD9 NEDD9 BANK1 BANK1 IL2 IL2 CSF3 CSF3 EREG EREG Cd24 Cd24 FGF7 FGF7 ANGPT1 ANGPT1 SYK SYK NRG1 NRG1 IL11 IL11 VTN VTN TNFSF18 TNFSF18 HDAC2 HDAC2 WNT3A WNT3A H920_06451 H920_06451 TP53 TP53 CCK CCK CAV2 CAV2 PAK2 PAK2 FYN FYN TNK2 TNK2 TREM2 TREM2 HBEGF HBEGF HPX HPX PTPRJ PTPRJ AREG AREG KITLG KITLG SRCIN1 SRCIN1 NOX4 NOX4 CD40 CD40 LRP8 LRP8 FGF10 FGF10 Fcgr1a Fcgr1a H920_00188 H920_00188 LOC104854429 LOC104854429 CSF1R CSF1R UNC119 UNC119 BMP6 BMP6 ERBB4 ERBB4 NRP1 NRP1 ENPP2 ENPP2 YES1 YES1 HSF1 HSF1 THBS4 THBS4 PECAM1 PECAM1 NTF3 NTF3 GDNF GDNF CASS4 CASS4 ARRB2 ARRB2 CNTF CNTF IQGAP1 IQGAP1 IL24 IL24 Nrg3 Nrg3 DOK7 DOK7 IL34 IL34 TLR4 TLR4 PTPRZ1 PTPRZ1 MUSK MUSK GAS6 GAS6 KIT KIT SRC SRC EHD4 EHD4 CD36 CD36 Plpp3 Plpp3 IL23A IL23A IL15 IL15 HCLS1 HCLS1 H920_06580 H920_06580 LIF LIF LRP4 LRP4 LOC104857525 LOC104857525 NEURL1 NEURL1 LEP LEP CTNND1 CTNND1 IL12A IL12A Tslp Tslp TEX101 TEX101 ADAM17 ADAM17 VEGFB VEGFB EGFR EGFR CD3E CD3E GATA1 GATA1 EFNA5 EFNA5 IL21 IL21 EPO EPO PTPN1 PTPN1 BTC BTC SEMA4D SEMA4D ARHGEF2 ARHGEF2 STAP1 STAP1 Il18 Il18 LOC104860341 LOC104860341 HES1 HES1 OSBP OSBP IL13 IL13 ADRA1A ADRA1A MLST8 MLST8 PRNP PRNP PIBF1 PIBF1 GPRC5B GPRC5B IL31RA IL31RA NCF1 NCF1 PTPN11 PTPN11 EGF EGF IGF1 IGF1 LOC104852000 LOC104852000
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RICTORRapamycin-insensitive companion of mTOR. (1708 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (1146 aa)
ERCC6DNA excision repair protein ERCC-6. (1446 aa)
FBXW9F-box/WD repeat-containing protein 9. (444 aa)
RELNReelin. (2792 aa)
RASA1Ras GTPase-activating protein 1. (893 aa)
ABI1Abl interactor 1. (470 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
DVL2Segment polarity protein dishevelled like protein DVL-2. (736 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (803 aa)
DGKQDiacylglycerol kinase. (849 aa)
H920_05906ADP-ribosylation factor-like protein 2-binding protein. (153 aa)
DLG3Disks large like protein 3; Belongs to the MAGUK family. (850 aa)
FCER1AFc fragment of IgE receptor Ia. (245 aa)
EPHA4Ephrin type-A receptor 4. (986 aa)
EFNA1Ephrin-A1; Belongs to the ephrin family. (205 aa)
LYNTyrosine-protein kinase. (512 aa)
H920_09510Reelin. (279 aa)
Il5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
EPGNEpithelial mitogen. (152 aa)
CLCF1Cardiotrophin-like cytokine factor 1. (219 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (224 aa)
LRRK1Leucine-rich repeat serine/threonine-protein kinase 1. (2015 aa)
DLG4Disks large like protein 4; Belongs to the MAGUK family. (767 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2321 aa)
PARP14Poly [ADP-ribose] polymerase. (1807 aa)
Arl2bpADP ribosylation factor like GTPase 2 binding protein. (163 aa)
AFAP1L2Actin filament-associated protein 1-like 2. (825 aa)
CNTN1Contactin-1. (1016 aa)
ADIPOQAdiponectin. (246 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2. (482 aa)
H920_19261Pro-neuregulin-2, membrane-bound isoform. (251 aa)
Tnfrsf18Tumor necrosis factor receptor superfamily member 18. (199 aa)
AGTAngiotensinogen; Belongs to the serpin family. (478 aa)
ICAM1Intercellular adhesion molecule 1. (500 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (725 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (991 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
ADNPActivity-dependent neuroprotector homeobox protein. (1103 aa)
AGRNAgrin. (2039 aa)
FGFR3Fibroblast growth factor receptor 3. (748 aa)
CSF2Uncharacterized protein. (144 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
HTR2A5-hydroxytryptamine receptor 2A; Belongs to the G-protein coupled receptor 1 family. (470 aa)
TGFAProtransforming growth factor alpha. (157 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2551 aa)
CD81Tetraspanin. (214 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
FBXW7F-box/WD repeat-containing protein 7. (708 aa)
IGF2Insulin-like growth factor II. (192 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1308 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (761 aa)
Alkal2Protein FAM150B. (126 aa)
ALKALK receptor tyrosine kinase. (1068 aa)
GREM1Gremlin-1. (184 aa)
PTK2BProtein-tyrosine kinase 2-beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (492 aa)
ALKAL1ALK and LTK ligand 1. (127 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1097 aa)
VegfaVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (186 aa)
CRLF1Cytokine receptor-like factor 1. (374 aa)
NEDD9Enhancer of filamentation 1. (833 aa)
BANK1B-cell scaffold protein with ankyrin repeats. (744 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
CSF3Colony stimulating factor 3. (204 aa)
EREGProepiregulin. (163 aa)
Cd24CD24 molecule. (69 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ANGPT1Angiopoietin-1. (416 aa)
SYKTyrosine-protein kinase. (629 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform. (699 aa)
IL11Interleukin-11. (193 aa)
VTNVitronectin. (431 aa)
TNFSF18Tumor necrosis factor ligand superfamily member 18. (186 aa)
HDAC2Histone deacetylase 2. (484 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
H920_06451Chondroitin sulfate proteoglycan 4. (803 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
CCKCholecystokinin. (109 aa)
CAV2Caveolin 2. (143 aa)
PAK2Non-specific serine/threonine protein kinase. (525 aa)
FYNTyrosine-protein kinase. (537 aa)
TNK2Activated CDC42 kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1042 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (231 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
HPXHemopexin. (463 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1115 aa)
AREGAmphiregulin. (242 aa)
KITLGKit ligand. (272 aa)
SRCIN1SRC kinase signaling inhibitor 1. (855 aa)
NOX4NADPH oxidase 4. (559 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (244 aa)
LRP8Low-density lipoprotein receptor-related protein 8. (837 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
Fcgr1aFc fragment of IgG receptor Ia. (374 aa)
H920_00188SH2 domain-containing protein 1B. (83 aa)
LOC104854429Angiopoietin-4. (335 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (988 aa)
UNC119Protein unc-119 like protein A. (261 aa)
BMP6Bone morphogenetic protein 6. (319 aa)
ERBB4Receptor tyrosine-protein kinase erbB-4. (1280 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (898 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2. (901 aa)
YES1Tyrosine-protein kinase. (541 aa)
HSF1Heat shock factor protein 1. (504 aa)
THBS4Thrombospondin-4. (901 aa)
PECAM1Platelet endothelial cell adhesion molecule. (740 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
GDNFGlial cell line-derived neurotrophic factor. (240 aa)
CASS4Cas scaffolding protein family member 4. (760 aa)
ARRB2Beta-arrestin-2. (409 aa)
CNTFCiliary neurotrophic factor. (179 aa)
IQGAP1Ras GTPase-activating-like protein IQGAP1. (1638 aa)
IL24Interleukin-24. (202 aa)
Nrg3Pro-neuregulin-3, membrane-bound isoform. (414 aa)
DOK7Docking protein 7. (447 aa)
IL34Interleukin-34. (216 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (839 aa)
PTPRZ1Receptor-type tyrosine-protein phosphatase zeta. (1460 aa)
MUSKMuscle, skeletal receptor tyrosine-protein kinase. (871 aa)
GAS6Growth arrest-specific protein 6. (667 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (955 aa)
SRCSRC proto-oncogene, non-receptor tyrosine kinase. (476 aa)
EHD4EH domain-containing protein 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (479 aa)
CD36Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
Plpp3Lipid phosphate phosphohydrolase 3. (288 aa)
IL23AInterleukin-23 subunit alpha. (189 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (181 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (470 aa)
H920_06580HLA class II histocompatibility antigen gamma chain. (148 aa)
LIFLeukemia inhibitory factor. (202 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1887 aa)
LOC104857525Cardiotrophin-2. (164 aa)
NEURL1Neuralized-like protein 1A. (355 aa)
LEPLeptin. (167 aa)
CTNND1Catenin delta-1. (937 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (240 aa)
TslpThymic stromal lymphopoietin. (96 aa)
TEX101CD177 antigen. (260 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17. (836 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (168 aa)
EGFRReceptor protein-tyrosine kinase. (1168 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (169 aa)
GATA1Erythroid transcription factor. (413 aa)
EFNA5Ephrin-A5; Belongs to the ephrin family. (228 aa)
IL21Interleukin 21. (155 aa)
EPOErythropoietin. (198 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (436 aa)
BTCProbetacellulin. (179 aa)
SEMA4DSemaphorin-4D; Belongs to the semaphorin family. (862 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (957 aa)
STAP1Signal-transducing adaptor protein 1. (291 aa)
Il18Interleukin-18. (293 aa)
LOC104860341Angiopoietin-4. (488 aa)
HES1Transcription factor HES-1. (278 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (686 aa)
IL13Interleukin 13. (133 aa)
ADRA1AAlpha-1A adrenergic receptor. (466 aa)
MLST8Target of rapamycin complex subunit LST8. (326 aa)
PRNPMajor prion protein; Belongs to the prion family. (236 aa)
PIBF1Uncharacterized protein. (756 aa)
GPRC5BG-protein coupled receptor family C group 5 member B. (412 aa)
IL31RAInterleukin-31 receptor subunit alpha. (710 aa)
NCF1Neutrophil cytosol factor 1. (390 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (600 aa)
EGFPro-epidermal growth factor. (1155 aa)
IGF1Insulin-like growth factor I. (158 aa)
LOC1048520001-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1255 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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