STRINGSTRING
CYBA CYBA LOC104852000 LOC104852000 DNM2 DNM2 RAP1A RAP1A ATG3 ATG3 Cfb Cfb ENSFDAP00000002122 ENSFDAP00000002122 MASP1 MASP1 SLC11A1 SLC11A1 COLEC10 COLEC10 STAP1 STAP1 SNX3 SNX3 SCARB1 SCARB1 LOC104853181 LOC104853181 TLR2 TLR2 GATA2 GATA2 TNF TNF SFTPD SFTPD PLA2G5 PLA2G5 PROS1 PROS1 TUB TUB MYO18A MYO18A CAMK1D CAMK1D IL15 IL15 CD36 CD36 GAS6 GAS6 SYT11 SYT11 CD300LF CD300LF LMAN2 LMAN2 ITGAV ITGAV ENSFDAP00000007466 ENSFDAP00000007466 FCN3 FCN3 DOCK2 DOCK2 RAB31 RAB31 DYSF DYSF IL2RB IL2RB ATG7 ATG7 MFGE8 MFGE8 Fcgr1a Fcgr1a LRP1 LRP1 CNN2 CNN2 PTPRJ PTPRJ H920_10688 H920_10688 TREM2 TREM2 MEX3B MEX3B LYAR LYAR FGR FGR BCR BCR SYK SYK Il2rg Il2rg CSK CSK LETMD1 LETMD1 Atg5 Atg5 LOC104865813 LOC104865813 RAB27A RAB27A NOD2 NOD2 PRKCG PRKCG COLEC11 COLEC11 ABCA7 ABCA7 C2 C2 SPHK1 SPHK1 PTEN PTEN PPARG PPARG MBL2 MBL2 PIP4P2 PIP4P2 Sirpa Sirpa Pycard Pycard ENSFDAP00000017469 ENSFDAP00000017469 BTK BTK APPL1 APPL1 ENSFDAP00000017826 ENSFDAP00000017826 PTK2 PTK2 RAPGEF1 RAPGEF1 TMEM147 TMEM147 F2RL1 F2RL1 Il1b Il1b APOA1 APOA1 FER1L5 FER1L5 CALR CALR TGM2 TGM2 APOA2 APOA2 MASP2 MASP2 ADIPOQ ADIPOQ RAP1GAP RAP1GAP SYT7 SYT7 ABR ABR SOD1 SOD1 RACK1 RACK1 AHSG AHSG AGER AGER NCKAP1L NCKAP1L CLEC7A CLEC7A FCN1 FCN1 ITGA2 ITGA2 APPL2 APPL2 MERTK MERTK PTPRC PTPRC ANO6 ANO6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CYBACytochrome b-245 light chain. (170 aa)
LOC1048520001-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1255 aa)
DNM2Dynamin-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (791 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
ATG3Autophagy-related protein 3. (313 aa)
CfbComplement factor B. (766 aa)
ENSFDAP00000002122annotation not available (80 aa)
MASP1Mannan binding lectin serine peptidase 1. (699 aa)
SLC11A1Natural resistance-associated macrophage protein 1. (548 aa)
COLEC10Collectin-10. (277 aa)
STAP1Signal-transducing adaptor protein 1. (291 aa)
SNX3Sorting nexin-3. (134 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (502 aa)
LOC104853181Tyrosine-protein phosphatase non-receptor type substrate 1. (470 aa)
TLR2Toll-like receptor 2. (718 aa)
GATA2Endothelial transcription factor GATA-2. (480 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
SFTPDPulmonary surfactant-associated protein D. (375 aa)
PLA2G5Phospholipase A(2). (138 aa)
PROS1Vitamin K-dependent protein S. (676 aa)
TUBTubby-like protein; Belongs to the TUB family. (504 aa)
MYO18AMyosin-XVIIIa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2085 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (356 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (181 aa)
CD36Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
GAS6Growth arrest-specific protein 6. (667 aa)
SYT11Synaptotagmin-11. (431 aa)
CD300LFCMRF35-like molecule 1. (299 aa)
LMAN2Vesicular integral-membrane protein VIP36. (356 aa)
ITGAVIntegrin alpha-V; Belongs to the integrin alpha chain family. (996 aa)
ENSFDAP00000007466annotation not available (44 aa)
FCN3Ficolin-3. (293 aa)
DOCK2Dedicator of cytokinesis protein 2; Belongs to the DOCK family. (1830 aa)
RAB31RAB31, member RAS oncogene family. (183 aa)
DYSFDysferlin. (2120 aa)
IL2RBInterleukin-2 receptor subunit beta. (528 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (699 aa)
MFGE8Lactadherin. (443 aa)
Fcgr1aFc fragment of IgG receptor Ia. (374 aa)
LRP1Prolow-density lipoprotein receptor-related protein 1. (4419 aa)
CNN2Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (307 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1115 aa)
H920_10688Pentaxin. (218 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (231 aa)
MEX3BMex-3 RNA binding family member B. (398 aa)
LYARLy1 antibody reactive. (385 aa)
FGRTyrosine-protein kinase. (526 aa)
BCRBreakpoint cluster region protein. (1221 aa)
SYKTyrosine-protein kinase. (629 aa)
Il2rgCytokine receptor common subunit gamma. (386 aa)
CSKC-terminal Src kinase. (450 aa)
LETMD1LETM1 domain-containing protein 1. (360 aa)
Atg5Autophagy protein 5; Involved in autophagic vesicle formation. (198 aa)
LOC104865813Pulmonary surfactant-associated protein A. (240 aa)
RAB27ARAB27A, member RAS oncogene family. (220 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1097 aa)
PRKCGProtein kinase C. (680 aa)
COLEC11Collectin-11. (272 aa)
ABCA7ATP-binding cassette sub-family A member 7. (1989 aa)
C2Complement C2. (733 aa)
SPHK1Sphingosine kinase 1. (406 aa)
PTENPhosphatase and tensin homolog. (403 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
MBL2Mannose-binding protein C. (241 aa)
PIP4P2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
SirpaTyrosine-protein phosphatase non-receptor type substrate 1. (509 aa)
PycardApoptosis-associated speck-like protein containing a CARD. (122 aa)
ENSFDAP00000017469annotation not available (306 aa)
BTKTyrosine-protein kinase. (658 aa)
APPL1DCC-interacting protein 13-alpha. (690 aa)
ENSFDAP00000017826annotation not available (133 aa)
PTK2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1083 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1211 aa)
TMEM147Transmembrane protein 147. (224 aa)
F2RL1Proteinase-activated receptor 2. (370 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
APOA1Apolipoprotein A1. (264 aa)
FER1L5Fer-1-like protein 5. (1957 aa)
CALRCalreticulin. (417 aa)
TGM2Transglutaminase 2. (691 aa)
APOA2Apolipoprotein A-II. (101 aa)
MASP2Mannan-binding lectin serine protease 2; Belongs to the peptidase S1 family. (646 aa)
ADIPOQAdiponectin. (246 aa)
RAP1GAPRAP1 GTPase activating protein. (663 aa)
SYT7Synaptotagmin-7. (556 aa)
ABRActive breakpoint cluster region-related protein. (853 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (138 aa)
RACK1Guanine nucleotide-binding protein subunit beta-2-like 1. (317 aa)
AHSGAlpha-2-HS-glycoprotein. (354 aa)
AGERAdvanced glycosylation end product-specific receptor. (418 aa)
NCKAP1LNck-associated protein 1-like. (1133 aa)
CLEC7AC-type lectin domain family 7 member A. (201 aa)
FCN1Ficolin-1. (319 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1179 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (644 aa)
MERTKTyrosine-protein kinase Mer. (986 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (1146 aa)
ANO6Anoctamin. (910 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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