(33 nodes) Regulation of type I interferon-mediated signaling pathway network (Fukomys damarensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TTLL12	Tubulin tyrosine ligase like 12. (616 aa)
	STAT2	Signal transducer and activator of transcription. (834 aa)
	LSM14A	Protein LSM14 like protein A. (433 aa)
	YTHDF2	YTH domain family protein 2; Belongs to the G-protein coupled receptor 1 family. (570 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (389 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	Usp18	Ubl carboxyl-terminal hydrolase 18; Belongs to the peptidase C19 family. (60 aa)
	Ikbke	Inhibitor of nuclear factor kappa-B kinase subunit epsilon. (130 aa)
	MMP12	Macrophage metalloelastase. (471 aa)
	STING1	Transmembrane protein 173. (378 aa)
	METTL3	N6-adenosine-methyltransferase 70 kDa subunit; Belongs to the MT-A70-like family. (580 aa)
	MAVS	Mitochondrial antiviral-signaling protein. (507 aa)
	TRIM56	E3 ubiquitin-protein ligase TRIM56. (733 aa)
	NLRC5	Protein NLRC5. (1784 aa)
	RNF185	RING finger protein 185. (192 aa)
	ADAR	Double-stranded RNA-specific adenosine deaminase. (932 aa)
	TRIM41	E3 ubiquitin-protein ligase TRIM41. (630 aa)
	DCST1	DC-STAMP domain containing 1. (614 aa)
	H920_00961	Tripartite motif-containing protein 6. (147 aa)
	SAMHD1	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (618 aa)
	CNOT7	CCR4-NOT transcription complex subunit 7. (285 aa)
	MUL1	Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
	YTHDF3	YTH domain family protein 3. (582 aa)
	ENSFDAP00000022247	annotation not available (88 aa)
	CACTIN	PIPK domain-containing protein. (691 aa)
	IRF7	Interferon regulatory factor 7. (430 aa)
	UBE2K	Ubiquitin conjugating enzyme E2 K. (179 aa)
	USP27X	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (437 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
	IRF3	Interferon regulatory factor 3. (428 aa)
	TBK1	Serine/threonine-protein kinase TBK1. (729 aa)
	TREX1	Three prime repair exonuclease 1. (314 aa)
	CDC37	Cell division cycle 37. (377 aa)

Your Current Organism:

Fukomys damarensis

NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	IRF7	ENSFDAP00000007613	ENSFDAP00000016433	Double-stranded RNA-specific adenosine deaminase.	Interferon regulatory factor 7.	0.415
ADAR	SAMHD1	ENSFDAP00000007613	ENSFDAP00000013008	Double-stranded RNA-specific adenosine deaminase.	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1.	0.514
ADAR	STAT2	ENSFDAP00000007613	ENSFDAP00000022293	Double-stranded RNA-specific adenosine deaminase.	Signal transducer and activator of transcription.	0.507
CDC37	FADD	ENSFDAP00000018762	ENSFDAP00000000029	Cell division cycle 37.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.572
CDC37	Ikbke	ENSFDAP00000018762	ENSFDAP00000001268	Cell division cycle 37.	Inhibitor of nuclear factor kappa-B kinase subunit epsilon.	0.516
CDC37	TBK1	ENSFDAP00000018762	ENSFDAP00000017895	Cell division cycle 37.	Serine/threonine-protein kinase TBK1.	0.491
CNOT7	YTHDF2	ENSFDAP00000014123	ENSFDAP00000023210	CCR4-NOT transcription complex subunit 7.	YTH domain family protein 2; Belongs to the G-protein coupled receptor 1 family.	0.592
CNOT7	YTHDF3	ENSFDAP00000014123	ENSFDAP00000015076	CCR4-NOT transcription complex subunit 7.	YTH domain family protein 3.	0.592
ENSFDAP00000022247	YTHDF2	ENSFDAP00000022247	ENSFDAP00000023210	annotation not available	YTH domain family protein 2; Belongs to the G-protein coupled receptor 1 family.	0.592
ENSFDAP00000022247	YTHDF3	ENSFDAP00000022247	ENSFDAP00000015076	annotation not available	YTH domain family protein 3.	0.592
FADD	CDC37	ENSFDAP00000000029	ENSFDAP00000018762	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Cell division cycle 37.	0.572
FADD	IRF3	ENSFDAP00000000029	ENSFDAP00000017443	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Interferon regulatory factor 3.	0.437
FADD	Ikbke	ENSFDAP00000000029	ENSFDAP00000001268	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Inhibitor of nuclear factor kappa-B kinase subunit epsilon.	0.558
FADD	MAVS	ENSFDAP00000000029	ENSFDAP00000003691	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Mitochondrial antiviral-signaling protein.	0.715
FADD	STAT2	ENSFDAP00000000029	ENSFDAP00000022293	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Signal transducer and activator of transcription.	0.432
FADD	STING1	ENSFDAP00000000029	ENSFDAP00000001813	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Transmembrane protein 173.	0.505
FADD	TBK1	ENSFDAP00000000029	ENSFDAP00000017895	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Serine/threonine-protein kinase TBK1.	0.613
FADD	Usp18	ENSFDAP00000000029	ENSFDAP00000000032	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Ubl carboxyl-terminal hydrolase 18; Belongs to the peptidase C19 family.	0.442
H920_00961	MAVS	ENSFDAP00000009986	ENSFDAP00000003691	Tripartite motif-containing protein 6.	Mitochondrial antiviral-signaling protein.	0.420
H920_00961	STING1	ENSFDAP00000009986	ENSFDAP00000001813	Tripartite motif-containing protein 6.	Transmembrane protein 173.	0.481