(17 nodes) Positive regulation of type I interferon-mediated signaling pathway network (Fukomys damarensis)

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second shell of interactors

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Known Interactions

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Predicted Interactions

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Your Input:
	NLRC5	Protein NLRC5. (1784 aa)
	TRIM56	E3 ubiquitin-protein ligase TRIM56. (733 aa)
	MAVS	Mitochondrial antiviral-signaling protein. (507 aa)
	STING1	Transmembrane protein 173. (378 aa)
	MMP12	Macrophage metalloelastase. (471 aa)
	Ikbke	Inhibitor of nuclear factor kappa-B kinase subunit epsilon. (130 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	TBK1	Serine/threonine-protein kinase TBK1. (729 aa)
	LSM14A	Protein LSM14 like protein A. (433 aa)
	IRF3	Interferon regulatory factor 3. (428 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
	USP27X	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (437 aa)
	UBE2K	Ubiquitin conjugating enzyme E2 K. (179 aa)
	IRF7	Interferon regulatory factor 7. (430 aa)
	H920_00961	Tripartite motif-containing protein 6. (147 aa)
	TRIM41	E3 ubiquitin-protein ligase TRIM41. (630 aa)
	RNF185	RING finger protein 185. (192 aa)

Your Current Organism:

Fukomys damarensis

NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FADD	IRF3	ENSFDAP00000000029	ENSFDAP00000017443	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Interferon regulatory factor 3.	0.437
FADD	Ikbke	ENSFDAP00000000029	ENSFDAP00000001268	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Inhibitor of nuclear factor kappa-B kinase subunit epsilon.	0.558
FADD	MAVS	ENSFDAP00000000029	ENSFDAP00000003691	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Mitochondrial antiviral-signaling protein.	0.715
FADD	STING1	ENSFDAP00000000029	ENSFDAP00000001813	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Transmembrane protein 173.	0.505
FADD	TBK1	ENSFDAP00000000029	ENSFDAP00000017895	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Serine/threonine-protein kinase TBK1.	0.613
H920_00961	MAVS	ENSFDAP00000009986	ENSFDAP00000003691	Tripartite motif-containing protein 6.	Mitochondrial antiviral-signaling protein.	0.420
H920_00961	STING1	ENSFDAP00000009986	ENSFDAP00000001813	Tripartite motif-containing protein 6.	Transmembrane protein 173.	0.481
H920_00961	UBE2K	ENSFDAP00000009986	ENSFDAP00000016657	Tripartite motif-containing protein 6.	Ubiquitin conjugating enzyme E2 K.	0.504
IRF3	FADD	ENSFDAP00000017443	ENSFDAP00000000029	Interferon regulatory factor 3.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.437
IRF3	IRF7	ENSFDAP00000017443	ENSFDAP00000016433	Interferon regulatory factor 3.	Interferon regulatory factor 7.	0.976
IRF3	Ikbke	ENSFDAP00000017443	ENSFDAP00000001268	Interferon regulatory factor 3.	Inhibitor of nuclear factor kappa-B kinase subunit epsilon.	0.983
IRF3	MAVS	ENSFDAP00000017443	ENSFDAP00000003691	Interferon regulatory factor 3.	Mitochondrial antiviral-signaling protein.	0.975
IRF3	STING1	ENSFDAP00000017443	ENSFDAP00000001813	Interferon regulatory factor 3.	Transmembrane protein 173.	0.985
IRF3	TBK1	ENSFDAP00000017443	ENSFDAP00000017895	Interferon regulatory factor 3.	Serine/threonine-protein kinase TBK1.	0.997
IRF3	TRIM56	ENSFDAP00000017443	ENSFDAP00000004646	Interferon regulatory factor 3.	E3 ubiquitin-protein ligase TRIM56.	0.440
IRF7	IRF3	ENSFDAP00000016433	ENSFDAP00000017443	Interferon regulatory factor 7.	Interferon regulatory factor 3.	0.976
IRF7	Ikbke	ENSFDAP00000016433	ENSFDAP00000001268	Interferon regulatory factor 7.	Inhibitor of nuclear factor kappa-B kinase subunit epsilon.	0.944
IRF7	MAVS	ENSFDAP00000016433	ENSFDAP00000003691	Interferon regulatory factor 7.	Mitochondrial antiviral-signaling protein.	0.708
IRF7	STING1	ENSFDAP00000016433	ENSFDAP00000001813	Interferon regulatory factor 7.	Transmembrane protein 173.	0.693
IRF7	TBK1	ENSFDAP00000016433	ENSFDAP00000017895	Interferon regulatory factor 7.	Serine/threonine-protein kinase TBK1.	0.969