STRINGSTRING
PPARG PPARG TGFB3 TGFB3 TGFBR1 TGFBR1 PARP1 PARP1 BMP6 BMP6 NUP93 NUP93 BMPR1A BMPR1A NODAL NODAL KIAA0319 KIAA0319 RBPMS RBPMS BMP2 BMP2 TGFB1 TGFB1 SMAD4 SMAD4 SH2B1 SH2B1 BMP4 BMP4 JAK2 JAK2 DAB2 DAB2 BMPR2 BMPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (470 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (973 aa)
BMP6Bone morphogenetic protein 6. (319 aa)
NUP93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (819 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NODALNodal growth differentiation factor. (322 aa)
KIAA0319Dyslexia-associated protein KIAA0319. (1123 aa)
RBPMSRNA binding protein, mRNA processing factor. (197 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
TGFB1Transforming growth factor beta-1. (333 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SH2B1SH2B adaptor protein 1. (738 aa)
BMP4Bone morphogenetic protein 4. (410 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
DAB2Disabled like protein 2. (769 aa)
BMPR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1025 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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