STRINGSTRING
SMAD4 SMAD4 ITGB6 ITGB6 Tshz1 Tshz1 FZD1 FZD1 COL11A2 COL11A2 TGFB2 TGFB2 TGFBR2 TGFBR2 LRRC32 LRRC32 WNT11 WNT11 WNT3A WNT3A LEF1 LEF1 WNT8A WNT8A CHD7 CHD7 TGFB3 TGFB3 TGFBR3 TGFBR3 SMAD2 SMAD2 ITGB8 ITGB8 JAG2 JAG2 WNT5A WNT5A MMP25 MMP25 GABRB3 GABRB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (807 aa)
Tshz1Teashirt like protein 1. (325 aa)
FZD1Frizzled class receptor 1. (486 aa)
COL11A2Collagen alpha-2(XI) chain. (1668 aa)
TGFB2Transforming growth factor beta 2. (398 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (560 aa)
LRRC32Guanylate cyclase. (663 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
LEF1Lymphoid enhancer-binding factor 1. (329 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
CHD7Chromodomain-helicase-DNA-binding protein 7. (2990 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGFBR3Transforming growth factor beta receptor type 3. (850 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (768 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1106 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
MMP25Matrix metallopeptidase 25. (524 aa)
GABRB3Gamma-aminobutyric acid receptor subunit beta-3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (403 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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