STRINGSTRING
TRAF3 TRAF3 EDA2R EDA2R Igbp1 Igbp1 TGFB2 TGFB2 Map2k2 Map2k2 SERPINF2 SERPINF2 MBIP MBIP EGFR EGFR RNF13 RNF13 PAFAH1B1 PAFAH1B1 SEMA4C SEMA4C AKT1 AKT1 TRPV4 TRPV4 ENSFDAP00000004169 ENSFDAP00000004169 TNF TNF LOC104854315 LOC104854315 Aida Aida SPI1 SPI1 LEP LEP CRACR2A CRACR2A LOC104870271 LOC104870271 ENSFDAP00000004787 ENSFDAP00000004787 Fas Fas COPS5 COPS5 ZMPSTE24 ZMPSTE24 MMP8 MMP8 Inava Inava LTBR LTBR IGF1R IGF1R MAP2K1 MAP2K1 EZR EZR DUSP22 DUSP22 TRAF4 TRAF4 MAP3K3 MAP3K3 MTURN MTURN GPS2 GPS2 TLR4 TLR4 TNIK TNIK SFRP1 SFRP1 H920_03440 H920_03440 ZC3H12A ZC3H12A Taok1 Taok1 RELL2 RELL2 DIXDC1 DIXDC1 Slamf1 Slamf1 TPD52L1 TPD52L1 TIRAP TIRAP RELL1 RELL1 PJA2 PJA2 MARVELD3 MARVELD3 CCL19 CCL19 MYD88 MYD88 ENSFDAP00000008900 ENSFDAP00000008900 PLCB1 PLCB1 PRDX1 PRDX1 DUSP10 DUSP10 EDAR EDAR RASGRP1 RASGRP1 DAB2IP DAB2IP PBK PBK PRMT1 PRMT1 Stk3 Stk3 RASSF2 RASSF2 TAOK3 TAOK3 FOXM1 FOXM1 MAP3K1 MAP3K1 ENSFDAP00000010317 ENSFDAP00000010317 RIPK1 RIPK1 APP APP TREM2 TREM2 MAPK9 MAPK9 UNC5CL UNC5CL ENSFDAP00000011061 ENSFDAP00000011061 FLT4 FLT4 CARD9 CARD9 Dusp3 Dusp3 MAP4K2 MAP4K2 MET MET ARL6IP5 ARL6IP5 GRIK2 GRIK2 FOXO1 FOXO1 MINK1 MINK1 FKTN FKTN PDCD4 PDCD4 FGD4 FGD4 Pdcd10 Pdcd10 SFRP5 SFRP5 MAP3K7 MAP3K7 MAPK8IP3 MAPK8IP3 NOD2 NOD2 TRAF6 TRAF6 PTK2B PTK2B CD27 CD27 MAP3K5 MAP3K5 SPHK1 SPHK1 Cdc42 Cdc42 H920_05577 H920_05577 ENSFDAP00000016516 ENSFDAP00000016516 TNFRSF19 TNFRSF19 SASH1 SASH1 H920_10190 H920_10190 ENSFDAP00000016975 ENSFDAP00000016975 MAP3K11 MAP3K11 MAP2K7 MAP2K7 Pycard Pycard WNT5A WNT5A ENSFDAP00000017382 ENSFDAP00000017382 WNT7A WNT7A ENSFDAP00000017469 ENSFDAP00000017469 Eif2ak2 Eif2ak2 HIPK3 HIPK3 TRAF5 TRAF5 MDFIC MDFIC DACT1 DACT1 DAB2 DAB2 TNFSF11 TNFSF11 XIAP XIAP QARS1 QARS1 RAPGEF1 RAPGEF1 KLHL31 KLHL31 F2RL1 F2RL1 Il1b Il1b CRHR2 CRHR2 NOD1 NOD1 HDAC3 HDAC3 MEN1 MEN1 HGF HGF SFRP2 SFRP2 HAND2 HAND2 Tlr3 Tlr3 CRK CRK MAGI3 MAGI3 MAPK8IP2 MAPK8IP2 RIPK2 RIPK2 ZMYND11 ZMYND11 SFRP4 SFRP4 H920_16434 H920_16434 MAPK3 MAPK3 MAPK8IP1 MAPK8IP1 ANKRD6 ANKRD6 BMP4 BMP4 CCL21 CCL21 NBR1 NBR1 H920_06994 H920_06994 MAPK1 MAPK1 DUSP1 DUSP1 CYLD CYLD PER1 PER1 XDH XDH IGFBP6 IGFBP6 MFHAS1 MFHAS1 SCIMP SCIMP SH3RF2 SH3RF2 LYN LYN AGER AGER NCOR1 NCOR1 KLHDC10 KLHDC10 MAP4K4 MAP4K4 H920_05445 H920_05445 EPHB1 EPHB1 RB1CC1 RB1CC1 MAP3K4 MAP3K4 AXIN1 AXIN1 CAV3 CAV3 NOX1 NOX1 DUSP16 DUSP16 H920_05489 H920_05489 SH3RF1 SH3RF1 TAOK2 TAOK2 GADD45G GADD45G TRAF1 TRAF1 MECOM MECOM STK25 STK25 WNT7B WNT7B NCF1 NCF1 DUSP19 DUSP19 TRAF2 TRAF2 Map2k4 Map2k4 WNT16 WNT16 ENSFDAP00000001424 ENSFDAP00000001424 PHLPP1 PHLPP1 BMP2 BMP2 EMC10 EMC10 ZNF622 ZNF622 SH3RF3 SH3RF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
EDA2RTumor necrosis factor receptor superfamily member 27. (299 aa)
Igbp1Immunoglobulin binding protein 1. (339 aa)
TGFB2Transforming growth factor beta 2. (398 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (370 aa)
SERPINF2Alpha-2-antiplasmin; Belongs to the serpin family. (427 aa)
MBIPMAP3K12-binding inhibitory protein 1. (343 aa)
EGFRReceptor protein-tyrosine kinase. (1168 aa)
RNF13E3 ubiquitin-protein ligase RNF13. (381 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
SEMA4CSemaphorin-4C; Belongs to the semaphorin family. (831 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
ENSFDAP00000004169annotation not available (234 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
LOC104854315Immunoglobulin-binding protein 1. (339 aa)
AidaAxin interactor, dorsalization associated. (288 aa)
SPI1Spi-1 proto-oncogene. (263 aa)
LEPLeptin. (167 aa)
CRACR2AEF-hand calcium-binding domain-containing protein 4B. (731 aa)
LOC104870271Glutathione S-transferase P 1. (210 aa)
ENSFDAP00000004787annotation not available (192 aa)
FasTumor necrosis factor receptor superfamily member 6. (290 aa)
COPS5COP9 signalosome complex subunit 5. (334 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
MMP8Matrix metallopeptidase 8. (469 aa)
InavaInnate immunity activator. (201 aa)
LTBRTumor necrosis factor receptor superfamily member 3. (499 aa)
IGF1RInsulin like growth factor 1 receptor. (1107 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (388 aa)
EZREzrin. (588 aa)
DUSP22Dual specificity protein phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (197 aa)
TRAF4TNF receptor-associated factor. (465 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (616 aa)
MTURNUncharacterized protein. (106 aa)
GPS2G protein pathway suppressor 2. (336 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (839 aa)
TNIKTRAF2 and NCK-interacting protein kinase. (1360 aa)
SFRP1Secreted frizzled-related protein 1. (285 aa)
H920_03440Nik-related protein kinase. (347 aa)
ZC3H12ARibonuclease ZC3H12A. (595 aa)
Taok1Serine/threonine-protein kinase TAO1. (1001 aa)
RELL2RELT-like protein 2. (302 aa)
DIXDC1Dixin. (711 aa)
Slamf1Signaling lymphocytic activation molecule. (323 aa)
TPD52L1Tumor protein D53. (197 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein. (209 aa)
RELL1RELT-like protein 1. (240 aa)
PJA2E3 ubiquitin-protein ligase Praja-2. (703 aa)
MARVELD3MARVEL domain-containing protein 3. (382 aa)
CCL19C-C motif chemokine. (104 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
ENSFDAP00000008900annotation not available (172 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
PRDX1Peroxiredoxin-1. (199 aa)
DUSP10Dual specificity protein phosphatase 10. (479 aa)
EDARTumor necrosis factor receptor superfamily member EDAR. (446 aa)
RASGRP1RAS guanyl-releasing protein 1. (796 aa)
DAB2IPDisabled like protein 2-interacting protein. (1161 aa)
PBKLymphokine-activated killer T-cell-originated protein kinase. (325 aa)
PRMT1Protein arginine N-methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
Stk3Serine/threonine-protein kinase 3. (493 aa)
RASSF2Ras association domain-containing protein 2. (326 aa)
TAOK3Serine/threonine-protein kinase TAO3. (898 aa)
FOXM1Forkhead box protein M1. (763 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1347 aa)
ENSFDAP00000010317annotation not available (274 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (660 aa)
APPAmyloid beta A4 protein. (766 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (231 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
UNC5CLUNC5C-like protein. (518 aa)
ENSFDAP00000011061annotation not available (840 aa)
FLT4Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1361 aa)
CARD9Caspase recruitment domain family member 9. (537 aa)
Dusp3Dual specificity phosphatase 3. (117 aa)
MAP4K2Mitogen-activated protein kinase kinase kinase kinase 2. (788 aa)
METHepatocyte growth factor receptor. (1382 aa)
ARL6IP5PRA1 family protein. (188 aa)
GRIK2Glutamate receptor, ionotropic kainate 2. (908 aa)
FOXO1Forkhead box protein O1. (522 aa)
MINK1Misshapen-like kinase 1. (1345 aa)
FKTNFukutin. (461 aa)
PDCD4Programmed cell death protein 4. (469 aa)
FGD4FYVE, RhoGEF and PH domain-containing protein 4. (769 aa)
Pdcd10Programmed cell death protein 10. (212 aa)
SFRP5Secreted frizzled-related protein 5. (301 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7. (606 aa)
MAPK8IP3C-Jun-amino-terminal kinase-interacting protein 3. (1319 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1097 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
PTK2BProtein-tyrosine kinase 2-beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CD27CD27 molecule. (233 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1300 aa)
SPHK1Sphingosine kinase 1. (406 aa)
Cdc42Cell division control protein 42 like protein. (191 aa)
H920_05577Mitogen-activated protein kinase-binding protein 1. (320 aa)
ENSFDAP00000016516annotation not available (156 aa)
TNFRSF19Tumor necrosis factor receptor superfamily member 19. (415 aa)
SASH1SAM and SH3 domain-containing protein 1. (1233 aa)
H920_10190Glutathione S-transferase P. (168 aa)
ENSFDAP00000016975annotation not available (180 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (848 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7. (427 aa)
PycardApoptosis-associated speck-like protein containing a CARD. (122 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
ENSFDAP00000017382annotation not available (171 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
ENSFDAP00000017469annotation not available (306 aa)
Eif2ak2Interferon-induced, double-stranded RNA-activated protein kinase. (448 aa)
HIPK3Homeodomain-interacting protein kinase 3. (1219 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
MDFICMyoD family inhibitor domain-containing protein. (215 aa)
DACT1Dapper like protein 1. (666 aa)
DAB2Disabled like protein 2. (769 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (287 aa)
XIAPBaculoviral IAP repeat-containing protein 4. (497 aa)
QARS1Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (774 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1211 aa)
KLHL31Kelch-like protein 31. (390 aa)
F2RL1Proteinase-activated receptor 2. (370 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
CRHR2Corticotropin-releasing factor receptor 2; Belongs to the G-protein coupled receptor 2 family. (419 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (824 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
MEN1Menin. (616 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (725 aa)
SFRP2Secreted frizzled-related protein 2. (286 aa)
HAND2Heart-and neural crest derivatives-expressed protein 2. (128 aa)
Tlr3Toll like receptor 3. (92 aa)
CRKCRK proto-oncogene, adaptor protein. (247 aa)
MAGI3Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3. (1395 aa)
MAPK8IP2Mitogen-activated protein kinase 8 interacting protein 2. (719 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2. (482 aa)
ZMYND11Zinc finger MYND domain-containing protein 11. (617 aa)
SFRP4Secreted frizzled-related protein 4. (316 aa)
H920_16434Serine/threonine-protein kinase 3. (439 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (563 aa)
ANKRD6Ankyrin repeat domain-containing protein 6. (715 aa)
BMP4Bone morphogenetic protein 4. (410 aa)
CCL21C-C motif chemokine 21. (129 aa)
NBR1Next to BRCA1 gene 1 protein. (986 aa)
H920_06994Natriuretic peptide A. (244 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (298 aa)
CYLDUbiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (951 aa)
PER1Period circadian protein like protein 1. (1279 aa)
XDHXanthine dehydrogenase/oxidase. (1336 aa)
IGFBP6Insulin-like growth factor-binding protein 6. (237 aa)
MFHAS1Malignant fibrous histiocytoma-amplified sequence 1. (1013 aa)
SCIMPSLP adaptor and CSK interacting membrane protein. (146 aa)
SH3RF2Putative E3 ubiquitin-protein ligase SH3RF2. (726 aa)
LYNTyrosine-protein kinase. (512 aa)
AGERAdvanced glycosylation end product-specific receptor. (418 aa)
NCOR1Nuclear receptor corepressor 1. (2434 aa)
KLHDC10Kelch domain-containing protein 10. (442 aa)
MAP4K4TRAF2 and NCK-interacting protein kinase. (1272 aa)
H920_05445C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (499 aa)
EPHB1Ephrin type-B receptor 1. (984 aa)
RB1CC1RB1-inducible coiled-coil protein 1. (1592 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1564 aa)
AXIN1Axin-1. (865 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
NOX1NADPH oxidase 1. (564 aa)
DUSP16Dual specificity protein phosphatase 16. (662 aa)
H920_05489Serine/threonine-protein kinase ULK4. (560 aa)
SH3RF1Putative E3 ubiquitin-protein ligase SH3RF1. (888 aa)
TAOK2Serine/threonine-protein kinase TAO2. (1240 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
TRAF1TNF receptor-associated factor. (415 aa)
MECOMUncharacterized protein. (1051 aa)
STK25Serine/threonine-protein kinase 25. (417 aa)
WNT7BWnt family member 7B. (349 aa)
NCF1Neutrophil cytosol factor 1. (390 aa)
DUSP19Dual specificity protein phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (238 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
Map2k4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (381 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
ENSFDAP00000001424annotation not available (259 aa)
PHLPP1PH domain leucine-rich repeat-containing protein phosphatase 1. (1202 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
EMC10UPF0510 protein INM02. (254 aa)
ZNF622Zinc finger protein 622. (466 aa)
SH3RF3SH3 domain-containing RING finger protein 3. (610 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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