STRINGSTRING
NPC1 NPC1 LOC104847992 LOC104847992 CD9 CD9 CD81 CD81 PPARG PPARG LOC104860587 LOC104860587 CDH13 CDH13 SYK SYK LOC104860586 LOC104860586 Socs5 Socs5 CD36 CD36 HMGCS1 HMGCS1 FCER1G FCER1G LPL LPL SREBF2 SREBF2 ITGB1 ITGB1 LOC104872673 LOC104872673
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NPC1Niemann-Pick C1 protein. (1258 aa)
LOC104847992Suppressor of cytokine signaling 5. (495 aa)
CD9Tetraspanin. (158 aa)
CD81Tetraspanin. (214 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
LOC104860587Liver carboxylesterase 22. (314 aa)
CDH13Cadherin-13. (713 aa)
SYKTyrosine-protein kinase. (629 aa)
LOC104860586Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
Socs5Suppressor of cytokine signaling 5. (536 aa)
CD36Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1120 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (803 aa)
LOC104872673Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (545 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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