STRINGSTRING
PIAS4 PIAS4 NSD2 NSD2 ENSFDAP00000002052 ENSFDAP00000002052 ENSFDAP00000002145 ENSFDAP00000002145 RECQL5 RECQL5 BLM BLM POT1 POT1 SMCHD1 SMCHD1 PPP4R3B PPP4R3B POLQ POLQ WDR48 WDR48 ENSFDAP00000004786 ENSFDAP00000004786 WAS WAS DTX3L DTX3L SHLD1 SHLD1 UBR5 UBR5 RAD51 RAD51 EPC2 EPC2 MAD2L2 MAD2L2 RMI2 RMI2 PPP4C PPP4C BCL7C BCL7C ENSFDAP00000006648 ENSFDAP00000006648 KDM1A KDM1A PARPBP PARPBP PPP4R2 PPP4R2 ZCWPW1 ZCWPW1 OTUB2 OTUB2 DMAP1 DMAP1 RAD51AP1 RAD51AP1 HSF1 HSF1 TRIP12 TRIP12 RUVBL1 RUVBL1 EP400 EP400 CHEK1 CHEK1 SIRT7 SIRT7 PRKDC PRKDC RPA2 RPA2 SLF2 SLF2 ERCC6 ERCC6 OGG1 OGG1 KMT5C KMT5C H920_01108 H920_01108 TEX15 TEX15 KLHL15 KLHL15 ENSFDAP00000008831 ENSFDAP00000008831 TIMELESS TIMELESS RIF1 RIF1 VPS72 VPS72 ENSFDAP00000009158 ENSFDAP00000009158 FH FH PARP3 PARP3 RBBP8 RBBP8 PARP1 PARP1 YEATS4 YEATS4 H920_07462 H920_07462 FOXM1 FOXM1 RNF169 RNF169 HELQ HELQ H920_12355 H920_12355 POGZ POGZ MGMT MGMT PML PML FIGNL1 FIGNL1 TRRAP TRRAP ZNF365 ZNF365 SETD2 SETD2 HELB HELB Actb Actb LOC104851526 LOC104851526 ACTR2 ACTR2 H920_12193 H920_12193 ACTL6A ACTL6A ARID2 ARID2 FANCB FANCB Rtel1 Rtel1 SHLD2 SHLD2 CYREN CYREN TP53BP1 TP53BP1 BRD8 BRD8 DDX11 DDX11 ING3 ING3 Spidr Spidr MMS19 MMS19 RUVBL2 RUVBL2 HDGFL2 HDGFL2 SPIRE1 SPIRE1 SLF1 SLF1 KDM4D KDM4D H920_10109 H920_10109 EPC1 EPC1 OTUB1 OTUB1 ENSFDAP00000017776 ENSFDAP00000017776 KMT5B KMT5B Dek Dek FAM178B FAM178B MORF4L1 MORF4L1 FBH1 FBH1 KAT5 KAT5 ENSFDAP00000019336 ENSFDAP00000019336 MEAF6 MEAF6 SIRT6 SIRT6 AUNIP AUNIP MBTD1 MBTD1 WRAP53 WRAP53 UBQLN4 UBQLN4 BCL7B BCL7B ENSFDAP00000020831 ENSFDAP00000020831 H920_00078 H920_00078 FUS FUS UBE2V2 UBE2V2 TERF2IP TERF2IP ENSFDAP00000022228 ENSFDAP00000022228
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIAS4Protein inhibitor of activated STAT 4. (386 aa)
NSD2Putative histone-lysine N-methyltransferase NSD2. (1366 aa)
ENSFDAP00000002052annotation not available (317 aa)
ENSFDAP00000002145annotation not available (192 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (967 aa)
BLMBloom syndrome protein. (1348 aa)
POT1Protection of telomeres 1. (637 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain-containing protein 1. (1920 aa)
PPP4R3BSerine/threonine-protein phosphatase 4 regulatory subunit 3. (820 aa)
POLQDNA polymerase theta. (2565 aa)
WDR48WD repeat-containing protein 48. (677 aa)
ENSFDAP00000004786annotation not available (71 aa)
WASWASP actin nucleation promoting factor. (420 aa)
DTX3LE3 ubiquitin-protein ligase DTX3L. (738 aa)
SHLD1Shieldin complex subunit 1. (203 aa)
UBR5E3 ubiquitin-protein ligase UBR5. (2791 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
EPC2Enhancer of polycomb homolog. (804 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
RMI2RecQ mediated genome instability 2. (89 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
BCL7CBAF chromatin remodeling complex subunit BCL7C. (147 aa)
ENSFDAP00000006648annotation not available (129 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (750 aa)
PARPBPUncharacterized protein. (579 aa)
PPP4R2Serine/threonine-protein phosphatase 4 regulatory subunit 2. (403 aa)
ZCWPW1Zinc finger CW-type PWWP domain protein 1. (611 aa)
OTUB2Ubiquitin thioesterase OTUB2. (234 aa)
DMAP1DNA methyltransferase 1-associated protein 1. (468 aa)
RAD51AP1RAD51-associated protein 1. (335 aa)
HSF1Heat shock factor protein 1. (504 aa)
TRIP12Putative E3 ubiquitin-protein ligase TRIP12. (2026 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
EP400E1A-binding protein p400. (3036 aa)
CHEK1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa)
SIRT7NAD-dependent deacetylase sirtuin-7. (400 aa)
PRKDCDNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family. (4143 aa)
RPA2Replication protein A 32 kDa subunit. (270 aa)
SLF2Protein FAM178A. (1168 aa)
ERCC6DNA excision repair protein ERCC-6. (1446 aa)
OGG1N-glycosylase/DNA lyase. (335 aa)
KMT5CHistone-lysine N-methyltransferase SUV420H2. (377 aa)
H920_01108MRG-binding protein. (75 aa)
TEX15Testis-expressed sequence 15 protein. (3116 aa)
KLHL15Kelch-like protein 15. (604 aa)
ENSFDAP00000008831annotation not available (330 aa)
TIMELESSProtein timeless like protein. (1207 aa)
RIF1Replication timing regulatory factor 1. (2455 aa)
VPS72Vacuolar protein sorting-associated protein 72 like protein. (364 aa)
ENSFDAP00000009158annotation not available (49 aa)
FHFumarate hydratase, mitochondrial. (508 aa)
PARP3Poly [ADP-ribose] polymerase. (531 aa)
RBBP8RB binding protein 8, endonuclease. (901 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (973 aa)
YEATS4YEATS domain-containing protein 4. (227 aa)
H920_07462Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
FOXM1Forkhead box protein M1. (763 aa)
RNF169RING finger protein 169. (609 aa)
HELQHelicase POLQ-like. (987 aa)
H920_12355Bifunctional polynucleotide phosphatase/kinase. (173 aa)
POGZPogo transposable element with ZNF domain. (1413 aa)
MGMTMethylated-DNA--protein-cysteine methyltransferase. (209 aa)
PMLProtein PML. (634 aa)
FIGNL1Fidgetin-like protein 1; Belongs to the AAA ATPase family. (676 aa)
TRRAPTransformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. (3838 aa)
ZNF365Protein ZNF365. (407 aa)
SETD2Histone-lysine N-methyltransferase SETD2. (2538 aa)
HELBDNA helicase B. (993 aa)
ActbActin, cytoplasmic 1. (375 aa)
LOC104851526Histone-lysine N-methyltransferase SETMAR. (299 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
H920_12193Actin, cytoplasmic type 8; Belongs to the actin family. (187 aa)
ACTL6AActin-like protein 6A; Belongs to the actin family. (429 aa)
ARID2AT-rich interactive domain-containing protein 2. (1765 aa)
FANCBFanconi anemia group B protein. (715 aa)
Rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1419 aa)
SHLD2Protein FAM35A. (888 aa)
CYRENCell cycle regulator of NHEJ. (166 aa)
TP53BP1Tumor suppressor p53-binding protein 1. (1958 aa)
BRD8Bromodomain-containing protein 8. (951 aa)
DDX11DEAD/H-box helicase 11. (772 aa)
ING3Inhibitor of growth protein. (418 aa)
SpidrUncharacterized protein. (552 aa)
MMS19MMS19 nucleotide excision repair protein like protein. (1022 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
HDGFL2Hepatoma-derived growth factor-related protein 2. (556 aa)
SPIRE1Protein spire like protein 1. (713 aa)
SLF1Ankyrin repeat domain-containing protein 32. (1057 aa)
KDM4DLysine-specific demethylase 4D. (523 aa)
H920_10109MRG domain-containing protein. (324 aa)
EPC1Enhancer of polycomb homolog. (813 aa)
OTUB1Ubiquitin thioesterase. (271 aa)
ENSFDAP00000017776annotation not available (72 aa)
KMT5BHistone-lysine N-methyltransferase SUV420H1. (883 aa)
DekDEK proto-oncogene. (377 aa)
FAM178BFamily with sequence similarity 178 member B. (513 aa)
MORF4L1MRG domain-containing protein. (348 aa)
FBH1F-box only protein 18. (1042 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
ENSFDAP00000019336annotation not available (242 aa)
MEAF6MYST/Esa1 associated factor 6. (171 aa)
SIRT6NAD-dependent deacetylase sirtuin-6. (282 aa)
AUNIPUncharacterized protein. (330 aa)
MBTD1MBT domain-containing protein 1. (647 aa)
WRAP53Telomerase Cajal body protein 1. (507 aa)
UBQLN4Ubiquilin-4. (558 aa)
BCL7BBAF chromatin remodeling complex subunit BCL7B. (176 aa)
ENSFDAP00000020831annotation not available (273 aa)
H920_00078Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (159 aa)
FUSRNA-binding protein FUS. (516 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
TERF2IPTelomeric repeat-binding factor 2-interacting protein 1. (391 aa)
ENSFDAP00000022228annotation not available (181 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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