(47 nodes) Ribonuclease H-like superfamily network (Fukomys damarensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PIWIL1	Piwi-like protein 1; Belongs to the argonaute family. (855 aa)
	REXO2	Oligoribonuclease, mitochondrial. (237 aa)
	ESRP2	Epithelial splicing regulatory protein 2. (694 aa)
	AGO3	Protein argonaute-3. (853 aa)
	NYNRIN	Protein NYNRIN. (1763 aa)
	POLQ	DNA polymerase theta. (2565 aa)
	TREX2	Three prime repair exonuclease 2. (236 aa)
	TEFM	Transcription elongation factor, mitochondrial. (360 aa)
	CNOT8	CCR4-NOT transcription complex subunit 8. (292 aa)
	ERI1	3'-5' exoribonuclease 1. (339 aa)
	POLG	DNA polymerase subunit gamma-1. (1219 aa)
	ERI3	ERI1 exoribonuclease 3. (337 aa)
	REXO4	RNA exonuclease 4. (417 aa)
	ZMYM1	Zinc finger MYM-type protein 1. (981 aa)
	SUPT6H	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
	SRBD1	S1 RNA-binding domain-containing protein 1. (955 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1210 aa)
	AGO1	Protein argonaute-1; Belongs to the argonaute family. (857 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa)
	PIWIL4	Piwi-like protein 4; Belongs to the argonaute family. (855 aa)
	POLA1	DNA polymerase. (1462 aa)
	TOE1	Target of EGR1 protein 1. (505 aa)
	H920_09325	Pol polyprotein. (851 aa)
	Piwil3	Piwi-like protein 3. (678 aa)
	Rexo1	RNA exonuclease 1 like protein. (508 aa)
	LOC104850912	Pol polyprotein. (744 aa)
	CNOT7	CCR4-NOT transcription complex subunit 7. (285 aa)
	GIN1	Gypsy retrotransposon integrase-like protein 1. (521 aa)
	ZNF618	Zinc finger protein 618. (943 aa)
	Rnaseh1	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (321 aa)
	EXOSC10	Exosome component 10. (887 aa)
	RNASEH2A	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (298 aa)
	PRPF8	Pre-mRNA-processing-splicing factor 8. (2335 aa)
	AGO2	Protein argonaute-2. (852 aa)
	H920_03142	General transcription factor II-I repeat domain-containing protein 2B. (46 aa)
	AEN	Apoptosis-enhancing nuclease. (320 aa)
	EXD2	Exonuclease 3'-5' domain-containing protein 2. (617 aa)
	TREX1	Three prime repair exonuclease 1. (314 aa)
	PARN	Poly(A)-specific ribonuclease PARN. (637 aa)
	WRN	Werner syndrome ATP-dependent helicase. (1439 aa)
	ISG20L2	Interferon-stimulated 20 kDa exonuclease-like 2. (384 aa)
	ZNF862	Zinc finger protein 862. (1133 aa)
	ISG20	Interferon-stimulated gene 20 kDa protein. (181 aa)
	PIWIL2	Piwi-like protein 2; Belongs to the argonaute family. (971 aa)
	REV3L	DNA polymerase zeta catalytic subunit. (3013 aa)
	PNLDC1	Poly(A)-specific ribonuclease PARN-like domain-containing protein 1. (531 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (854 aa)

Your Current Organism:

Fukomys damarensis

NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEN	EXOSC10	ENSFDAP00000018559	ENSFDAP00000015194	Apoptosis-enhancing nuclease.	Exosome component 10.	0.675
AEN	REXO2	ENSFDAP00000018559	ENSFDAP00000001933	Apoptosis-enhancing nuclease.	Oligoribonuclease, mitochondrial.	0.720
AEN	Rnaseh1	ENSFDAP00000018559	ENSFDAP00000014669	Apoptosis-enhancing nuclease.	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.559
AGO1	AGO2	ENSFDAP00000009125	ENSFDAP00000016292	Protein argonaute-1; Belongs to the argonaute family.	Protein argonaute-2.	0.985
AGO1	AGO3	ENSFDAP00000009125	ENSFDAP00000003418	Protein argonaute-1; Belongs to the argonaute family.	Protein argonaute-3.	0.822
AGO1	AGO4	ENSFDAP00000009125	ENSFDAP00000023313	Protein argonaute-1; Belongs to the argonaute family.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.736
AGO2	AGO1	ENSFDAP00000016292	ENSFDAP00000009125	Protein argonaute-2.	Protein argonaute-1; Belongs to the argonaute family.	0.985
AGO2	AGO3	ENSFDAP00000016292	ENSFDAP00000003418	Protein argonaute-2.	Protein argonaute-3.	0.971
AGO2	AGO4	ENSFDAP00000016292	ENSFDAP00000023313	Protein argonaute-2.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.925
AGO2	CNOT7	ENSFDAP00000016292	ENSFDAP00000014123	Protein argonaute-2.	CCR4-NOT transcription complex subunit 7.	0.430
AGO3	AGO1	ENSFDAP00000003418	ENSFDAP00000009125	Protein argonaute-3.	Protein argonaute-1; Belongs to the argonaute family.	0.822
AGO3	AGO2	ENSFDAP00000003418	ENSFDAP00000016292	Protein argonaute-3.	Protein argonaute-2.	0.971
AGO3	AGO4	ENSFDAP00000003418	ENSFDAP00000023313	Protein argonaute-3.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.693
AGO4	AGO1	ENSFDAP00000023313	ENSFDAP00000009125	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-1; Belongs to the argonaute family.	0.736
AGO4	AGO2	ENSFDAP00000023313	ENSFDAP00000016292	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-2.	0.925
AGO4	AGO3	ENSFDAP00000023313	ENSFDAP00000003418	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-3.	0.693
CNOT7	AGO2	ENSFDAP00000014123	ENSFDAP00000016292	CCR4-NOT transcription complex subunit 7.	Protein argonaute-2.	0.430
CNOT7	CNOT8	ENSFDAP00000014123	ENSFDAP00000005581	CCR4-NOT transcription complex subunit 7.	CCR4-NOT transcription complex subunit 8.	0.945
CNOT7	PAN2	ENSFDAP00000014123	ENSFDAP00000008933	CCR4-NOT transcription complex subunit 7.	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...]	0.408
CNOT7	POLA1	ENSFDAP00000014123	ENSFDAP00000010561	CCR4-NOT transcription complex subunit 7.	DNA polymerase.	0.575