STRINGSTRING
EZH2 EZH2 MRE11 MRE11 H920_01661 H920_01661 Mdm2 Mdm2 H920_00078 H920_00078 FOS FOS MAP2K3 MAP2K3 UBE2C UBE2C Rbbp7 Rbbp7 MAPK10 MAPK10 RPS6KA3 RPS6KA3 CABIN1 CABIN1 MAPK1 MAPK1 HIRA HIRA ETS2 ETS2 MAPK3 MAPK3 Cdkn1c Cdkn1c CDK3 CDK3 KAT5 KAT5 HMGA1 HMGA1 LMNB2 LMNB2 Ubc Ubc LOC104870593 LOC104870593 TLX2 TLX2 EHMT2 EHMT2 Tlx1 Tlx1 CDC27 CDC27 UBE2E1 UBE2E1 CCNA1 CCNA1 MAP2K7 MAP2K7 H2BC12 H2BC12 LOC104870592 LOC104870592 ANAPC16 ANAPC16 TM7SF3 TM7SF3 ENSFDAP00000015944 ENSFDAP00000015944 LOC104861347 LOC104861347 MAP3K5 MAP3K5 RBBP4 RBBP4 ANAPC15 ANAPC15 CCNA2 CCNA2 BARHL1 BARHL1 LOC104870598 LOC104870598 H920_04706 H920_04706 RPS27A RPS27A ANAPC4 ANAPC4 TLX3 TLX3 ANAPC10 ANAPC10 CDKN2C CDKN2C MINK1 MINK1 ASF1B ASF1B UBE2S UBE2S NPTX2 NPTX2 ATM ATM MAPKAPK3 MAPKAPK3 KDM6B KDM6B ENSFDAP00000011804 ENSFDAP00000011804 TP53 TP53 LOC104861528 LOC104861528 NME8 NME8 H1-6 H1-6 EHMT1 EHMT1 MAPK9 MAPK9 LMNB1 LMNB1 Srcap Srcap MAPK11 MAPK11 Fam89b Fam89b ENSFDAP00000010317 ENSFDAP00000010317 ETV3 ETV3 H920_03514 H920_03514 ENSFDAP00000009759 ENSFDAP00000009759 JUN JUN Anapc11 Anapc11 ID1 ID1 ANAPC7 ANAPC7 ENSFDAP00000007986 ENSFDAP00000007986 RPS6KA2 RPS6KA2 MAP2K6 MAP2K6 ID2 ID2 H920_03440 H920_03440 CCNE1 CCNE1 TNIK TNIK NBN NBN CDC26 CDC26 TXNDC8 TXNDC8 CBX7 CBX7 ANAPC5 ANAPC5 MAPK14 MAPK14 MAPK7 MAPK7 NPTXR NPTXR ENSFDAP00000004786 ENSFDAP00000004786 ENSFDAP00000004617 ENSFDAP00000004617 CDC16 CDC16 MAPK8 MAPK8 ERF ERF ETS1 ETS1 ENSFDAP00000004169 ENSFDAP00000004169 CDKN2B CDKN2B Txn Txn H920_13673 H920_13673 NPTX1 NPTX1 ANAPC2 ANAPC2 RPS6KA1 RPS6KA1 MAP3K15 MAP3K15 Rad50 Rad50 RB1 RB1 CCNE2 CCNE2 ASF1A ASF1A EZH1 EZH1 Map2k4 Map2k4 EP400 EP400 ANAPC1 ANAPC1 CDK2 CDK2 FZR1 FZR1 UBN1 UBN1 ENSFDAP00000002920 ENSFDAP00000002920 MAP3K6 MAP3K6 CBX2 CBX2 CDKN1A CDKN1A BARX2 BARX2 BARHL2 BARHL2 MAPKAPK2 MAPKAPK2 CDC23 CDC23 CDK4 CDK4 SUZ12 SUZ12 ERFL ERFL CDK6 CDK6 HLX HLX TNRC6B TNRC6B MDM4 MDM4 BARX1 BARX1 DBX2 DBX2 PHC3 PHC3 UBE2D1 UBE2D1 MAPKAPK5 MAPKAPK5 EED EED UBA52 UBA52 MAP4K4 MAP4K4 Phc1 Phc1 CDKN1B CDKN1B MOV10 MOV10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EZH2Histone-lysine N-methyltransferase EZH2. (746 aa)
MRE11MRE11 homolog, double strand break repair nuclease. (708 aa)
H920_01661Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (188 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2. (504 aa)
H920_00078Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (159 aa)
FOSProto-oncogene c-Fos. (380 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
UBE2CUbiquitin-conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
Rbbp7Histone-binding protein RBBP7. (419 aa)
MAPK10Mitogen-activated protein kinase. (478 aa)
RPS6KA3Non-specific serine/threonine protein kinase. (727 aa)
CABIN1Calcineurin-binding protein cabin-1; Belongs to the GST superfamily. (2183 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
HIRAProtein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1019 aa)
ETS2Protein C-ets-2; Transcription factor; Belongs to the ETS family. (470 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
Cdkn1cCyclin-dependent kinase inhibitor 1C. (127 aa)
CDK3Cyclin dependent kinase 3. (297 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
HMGA1High mobility group protein HMG-I/HMG-Y. (99 aa)
LMNB2Lamin B2. (451 aa)
UbcPolyubiquitin-B. (235 aa)
LOC104870593Histone H2B type 1-N. (126 aa)
TLX2T-cell leukemia homeobox protein 2. (253 aa)
EHMT2Histone-lysine N-methyltransferase EHMT2. (1227 aa)
Tlx1T-cell leukemia homeobox protein 1. (91 aa)
CDC27Cell division cycle 27. (825 aa)
UBE2E1Ubiquitin-conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (421 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7. (427 aa)
H2BC12H2B clustered histone 12. (126 aa)
LOC104870592Histone H2B; Belongs to the histone H2B family. (126 aa)
ANAPC16Anaphase-promoting complex subunit 16. (110 aa)
TM7SF3Transmembrane 7 superfamily member 3. (487 aa)
ENSFDAP00000015944annotation not available (350 aa)
LOC104861347Histone H2B; Belongs to the histone H2B family. (126 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1300 aa)
RBBP4Histone-binding protein RBBP4. (425 aa)
ANAPC15Protein HSPC020 like protein. (133 aa)
CCNA2Cyclin A2. (400 aa)
BARHL1BarH like homeobox 1. (285 aa)
LOC104870598Histone H2B type 1-K-like. (126 aa)
H920_04706Histone H2B type 1; Belongs to the histone H2B family. (143 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (808 aa)
TLX3T-cell leukemia homeobox protein 3. (252 aa)
ANAPC10Anaphase promoting complex subunit 10. (185 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
MINK1Misshapen-like kinase 1. (1345 aa)
ASF1BAnti-silencing function 1B histone chaperone. (202 aa)
UBE2SUbiquitin-conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (212 aa)
NPTX2Neuronal pentraxin-2. (383 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa)
MAPKAPK3MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
KDM6BLysine demethylase 6B. (1653 aa)
ENSFDAP00000011804annotation not available (202 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
LOC104861528Histone H2B; Belongs to the histone H2B family. (126 aa)
NME8Thioredoxin domain-containing protein 3. (539 aa)
H1-6Histone H1t. (216 aa)
EHMT1Histone-lysine N-methyltransferase EHMT1. (1270 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
LMNB1Lamin-B1; Belongs to the intermediate filament family. (516 aa)
SrcapHelicase SRCAP. (3197 aa)
MAPK11Mitogen-activated protein kinase 11. (325 aa)
Fam89bFamily with sequence similarity 89 member B. (93 aa)
ENSFDAP00000010317annotation not available (274 aa)
ETV3ETS domain-containing protein. (511 aa)
H920_03514Histone-binding protein RBBP4. (407 aa)
ENSFDAP00000009759annotation not available (105 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (254 aa)
Anapc11Anaphase-promoting complex subunit 11. (84 aa)
ID1DNA-binding protein inhibitor ID-1. (151 aa)
ANAPC7Anaphase-promoting complex subunit 7. (592 aa)
ENSFDAP00000007986annotation not available (79 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
H920_03440Nik-related protein kinase. (347 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (405 aa)
TNIKTRAF2 and NCK-interacting protein kinase. (1360 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (747 aa)
CDC26Transmembrane protein 71. (84 aa)
TXNDC8Thioredoxin domain containing 8. (127 aa)
CBX7Chromobox protein like protein 7. (249 aa)
ANAPC5Anaphase-promoting complex subunit 5. (755 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (808 aa)
NPTXRNeuronal pentraxin receptor. (348 aa)
ENSFDAP00000004786annotation not available (71 aa)
ENSFDAP00000004617annotation not available (366 aa)
CDC16Cell division cycle protein 16 like protein. (626 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ERFETS domain-containing transcription factor ERF. (549 aa)
ETS1Transforming protein p68/c-ets-1. (439 aa)
ENSFDAP00000004169annotation not available (234 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (138 aa)
TxnThioredoxin. (105 aa)
H920_13673ETS domain-containing protein. (156 aa)
NPTX1Neuronal pentraxin-1. (419 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (827 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
MAP3K15Mitogen-activated protein kinase kinase kinase 15. (1224 aa)
Rad50DNA repair protein RAD50. (1312 aa)
RB1Retinoblastoma-associated protein. (882 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (405 aa)
ASF1AAnti-silencing function 1A histone chaperone. (167 aa)
EZH1Histone-lysine N-methyltransferase EZH1. (748 aa)
Map2k4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (381 aa)
EP400E1A-binding protein p400. (3036 aa)
ANAPC1Anaphase-promoting complex subunit 1. (1944 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
FZR1Fizzy-related protein like protein. (493 aa)
UBN1Ubinuclein-1. (1136 aa)
ENSFDAP00000002920annotation not available (87 aa)
MAP3K6Mitogen-activated protein kinase kinase kinase 6. (1284 aa)
CBX2Chromobox protein like protein 2. (467 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (165 aa)
BARX2Homeobox protein BarH-like 2. (243 aa)
BARHL2BarH-like 2 homeobox protein. (332 aa)
MAPKAPK2MAP kinase-activated protein kinase 2. (399 aa)
CDC23Cell division cycle protein 23 like protein. (597 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
SUZ12Polycomb protein SUZ12. (659 aa)
ERFLETS domain-containing transcription factor ERF. (354 aa)
CDK6Cyclin-dependent kinase 6. (296 aa)
HLXH2.0-like homeobox protein. (320 aa)
TNRC6BTrinucleotide repeat-containing gene 6B protein. (1811 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (492 aa)
BARX1Homeobox protein BarH-like 1. (241 aa)
DBX2Homeobox protein DBX2. (203 aa)
PHC3Polyhomeotic-like protein 3. (984 aa)
UBE2D1Ubiquitin-conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (140 aa)
MAPKAPK5MAP kinase-activated protein kinase 5. (476 aa)
EEDPolycomb protein EED. (441 aa)
UBA52KxDL motif containing 1. (232 aa)
MAP4K4TRAF2 and NCK-interacting protein kinase. (1272 aa)
Phc1Polyhomeotic-like protein 1. (79 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
MOV10Putative helicase MOV-10. (1002 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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