STRINGSTRING
KIAA2012 KIAA2012 PSMA3 PSMA3 Pola2 Pola2 SKP1 SKP1 ORC2 ORC2 UBA52 UBA52 PSMA7 PSMA7 MEIOB MEIOB CCNH CCNH RPA1 RPA1 CDKN1B CDKN1B WEE1 WEE1 LOC104865314 LOC104865314 LYN LYN POLE2 POLE2 CDC45 CDC45 PSMA1 PSMA1 TFDP1 TFDP1 HDAC1 HDAC1 FNDC3A FNDC3A PSMC1 PSMC1 CUL1 CUL1 PSME1 PSME1 WEE2 WEE2 MCM9 MCM9 PSMD6 PSMD6 Cdkn1c Cdkn1c RELCH RELCH CDK3 CDK3 Psmd9 Psmd9 RBL2 RBL2 DYRK1B DYRK1B PPP2R1B PPP2R1B Tfdp2 Tfdp2 Ubc Ubc Prim1 Prim1 H920_01229 H920_01229 POLE3 POLE3 H920_15675 H920_15675 JAK2 JAK2 LIN9 LIN9 Ppp2ca Ppp2ca CCNA1 CCNA1 PSMB9 PSMB9 ORC4 ORC4 Mcm8 Mcm8 Ccnd3 Ccnd3 ENSFDAP00000015888 ENSFDAP00000015888 E2F4 E2F4 PSMB1 PSMB1 MCM6 MCM6 RBBP4 RBBP4 LOC104868352 LOC104868352 PSMB5 PSMB5 H920_20354 H920_20354 CCNA2 CCNA2 PSMD5 PSMD5 PRR5L PRR5L CKS1B CKS1B PSMB10 PSMB10 CDK7 CDK7 PSMA6 PSMA6 FNBP4 FNBP4 H920_02493 H920_02493 PPP2R2B PPP2R2B RPS27A RPS27A PSMA2 PSMA2 PSMD14 PSMD14 PTK6 PTK6 E2F5 E2F5 CDKN2C CDKN2C H920_07431 H920_07431 PPP2R3A PPP2R3A MYBL2 MYBL2 LIN52 LIN52 PSMA4 PSMA4 PSMC5 PSMC5 MCM4 MCM4 H920_05040 H920_05040 LIN54 LIN54 PSMB7 PSMB7 RPA3 RPA3 MCM2 MCM2 PPP2CB PPP2CB AKT3 AKT3 PSMD3 PSMD3 POLA1 POLA1 PPP4R1 PPP4R1 ENSFDAP00000010230 ENSFDAP00000010230 PSME2 PSME2 H920_03514 H920_03514 FNDC3B FNDC3B ORC5 ORC5 PSMC6 PSMC6 CDC7 CDC7 CKS2 CKS2 POLE POLE E2F3 E2F3 Cables1 Cables1 Tm4sf19 Tm4sf19 PSMB2 PSMB2 PSMD2 PSMD2 DBF4 DBF4 ENSFDAP00000007986 ENSFDAP00000007986 SKP2 SKP2 PSMB3 PSMB3 MCM10 MCM10 Tesmin Tesmin ORC6 ORC6 PPP4R4 PPP4R4 CDT1 CDT1 CCNE1 CCNE1 PSME3 PSME3 PSMB4 PSMB4 ORC1 ORC1 PSMD4 PSMD4 GMNN GMNN PSMF1 PSMF1 MCM5 MCM5 DYRK1A DYRK1A PSMD10 PSMD10 CREBZF CREBZF LIN37 LIN37 PSMD13 PSMD13 CDKN2B CDKN2B AKT1 AKT1 PSMD7 PSMD7 Ccnd2 Ccnd2 CDK2 CDK2 PRIM2 PRIM2 ENSFDAP00000002920 ENSFDAP00000002920 E2F1 E2F1 CDC6 CDC6 CDKN1A CDKN1A RBL1 RBL1 Ppp2r1a Ppp2r1a PSMD11 PSMD11 PSMB6 PSMB6 ORC3 ORC3 PSMC3 PSMC3 PSMD8 PSMD8 PPP2R2A PPP2R2A E2F2 E2F2 Mcm7 Mcm7 CDK4 CDK4 MCM3 MCM3 CCND1 CCND1 PPP2R3C PPP2R3C PSMA5 PSMA5 RB1 RB1 MNAT1 MNAT1 CCNE2 CCNE2 PSMD1 PSMD1 ENSFDAP00000000144 ENSFDAP00000000144 RPA2 RPA2 CDK6 CDK6 AKT2 AKT2 PSMC2 PSMC2 PSMC4 PSMC4 PSMD12 PSMD12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KIAA2012Uncharacterized protein. (1178 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
Pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (188 aa)
ORC2Origin recognition complex subunit 2. (599 aa)
UBA52KxDL motif containing 1. (232 aa)
PSMA7Proteasome endopeptidase complex. (216 aa)
MEIOBCDC24_OB3 domain-containing protein. (471 aa)
CCNHCyclin-H; Belongs to the cyclin family. (323 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (615 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
WEE1Zinc finger protein 143. (470 aa)
LOC104865314Serine/threonine-protein phosphatase 4 regulatory subunit 1. (941 aa)
LYNTyrosine-protein kinase. (512 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
CDC45Cell division control protein 45 like protein. (566 aa)
PSMA1Proteasome subunit alpha type-1. (264 aa)
TFDP1Transcription factor. (410 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
FNDC3AFibronectin type-III domain-containing protein 3A. (1198 aa)
PSMC126S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
PSME1Proteasome activator complex subunit 1. (249 aa)
WEE2Wee1-like protein kinase 2. (511 aa)
MCM9DNA replication licensing factor MCM9; Belongs to the MCM family. (1106 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6. (340 aa)
Cdkn1cCyclin-dependent kinase inhibitor 1C. (127 aa)
RELCHLisH domain and HEAT repeat-containing protein KIAA1468. (1216 aa)
CDK3Cyclin dependent kinase 3. (297 aa)
Psmd926S proteasome non-ATPase regulatory subunit 9. (223 aa)
RBL2Retinoblastoma-like protein 2. (1139 aa)
DYRK1BDual specificity tyrosine phosphorylation regulated kinase 1B. (617 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (653 aa)
Tfdp2Transcription factor Dp-2. (446 aa)
UbcPolyubiquitin-B. (235 aa)
Prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
H920_01229Cullin-1; Belongs to the cullin family. (265 aa)
POLE3DNA polymerase epsilon subunit 3. (147 aa)
H920_15675S-phase kinase-associated protein 1; Belongs to the SKP1 family. (135 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
LIN9Protein lin-9 like protein. (531 aa)
Ppp2caSerine/threonine-protein phosphatase. (275 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (421 aa)
PSMB9Proteasome subunit beta type-9. (219 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
Mcm8DNA replication licensing factor MCM8; Belongs to the MCM family. (833 aa)
Ccnd3G1/S-specific cyclin-D3; Belongs to the cyclin family. (96 aa)
ENSFDAP00000015888annotation not available (251 aa)
E2F4E2F transcription factor 4. (408 aa)
PSMB1Proteasome subunit beta. (240 aa)
MCM6DNA helicase; Belongs to the MCM family. (786 aa)
RBBP4Histone-binding protein RBBP4. (425 aa)
LOC104868352Glycine N-acyltransferase. (295 aa)
PSMB5Proteasome subunit beta. (263 aa)
H920_20354S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
CCNA2Cyclin A2. (400 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5. (504 aa)
PRR5LProline-rich protein 5-like. (368 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
PSMB10Proteasome subunit beta. (273 aa)
CDK7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
PSMA6Proteasome subunit alpha type. (247 aa)
FNBP4Formin binding protein 4. (916 aa)
H920_02493Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform. (509 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
PTK6Protein-tyrosine kinase 6. (451 aa)
E2F5E2F transcription factor 5. (299 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
H920_07431S-phase kinase-associated protein 1; Belongs to the SKP1 family. (136 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha. (1151 aa)
MYBL2Myb-related protein B. (694 aa)
LIN52Protein lin-52 like protein. (116 aa)
PSMA4Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (210 aa)
PSMC526S protease regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
H920_05040Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (97 aa)
LIN54Protein lin-54 like protein. (748 aa)
PSMB7Proteasome subunit beta type-7. (277 aa)
RPA3Replication protein A 14 kDa subunit. (122 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
AKT3Non-specific serine/threonine protein kinase. (480 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (331 aa)
POLA1DNA polymerase. (1462 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (928 aa)
ENSFDAP00000010230annotation not available (709 aa)
PSME2Proteasome activator complex subunit 2. (239 aa)
H920_03514Histone-binding protein RBBP4. (407 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1206 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
PSMC626S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (389 aa)
CDC7Cell division cycle 7-related protein kinase. (571 aa)
CKS2CDC28 protein kinase regulatory subunit 2. (79 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa)
E2F3Transcription factor E2F3. (334 aa)
Cables1CDK5 and ABL1 enzyme substrate 1. (305 aa)
Tm4sf19Transmembrane 4 L6 family member 19. (181 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMD2Proteasome 26S subunit, non-ATPase 2. (908 aa)
DBF4Protein DBF4 like protein A. (636 aa)
ENSFDAP00000007986annotation not available (79 aa)
SKP2S-phase kinase-associated protein 2. (424 aa)
PSMB3Proteasome subunit beta. (205 aa)
MCM10Protein MCM10 like protein. (874 aa)
TesminTesmin. (330 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4. (833 aa)
CDT1DNA replication factor Cdt1. (542 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (405 aa)
PSME3Proteasome activator complex subunit 3. (265 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (828 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4. (379 aa)
GMNNGeminin. (208 aa)
PSMF1Proteasome inhibitor PI31 subunit. (271 aa)
MCM5DNA helicase; Belongs to the MCM family. (678 aa)
DYRK1ADual specificity tyrosine-phosphorylation-regulated kinase 1A. (763 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10. (226 aa)
CREBZFCREB/ATF bZIP transcription factor. (307 aa)
LIN37Protein lin-37 like protein. (246 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (138 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (324 aa)
Ccnd2G1/S-specific cyclin-D2; Belongs to the cyclin family. (288 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (506 aa)
ENSFDAP00000002920annotation not available (87 aa)
E2F1Transcription factor E2F1. (377 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (165 aa)
RBL1RB transcriptional corepressor like 1. (1042 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (573 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (391 aa)
PSMB6Proteasome subunit beta. (239 aa)
ORC3Origin recognition complex subunit 3. (720 aa)
PSMC326S protease regulatory subunit 6A. (440 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (350 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform. (458 aa)
E2F2Transcription factor E2F2. (391 aa)
Mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MCM3DNA helicase; Belongs to the MCM family. (817 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma. (453 aa)
PSMA5Proteasome 20S subunit alpha 5. (241 aa)
RB1Retinoblastoma-associated protein. (882 aa)
MNAT1CDK-activating kinase assembly factor MAT1. (309 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (405 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1. (953 aa)
ENSFDAP00000000144annotation not available (263 aa)
RPA2Replication protein A 32 kDa subunit. (270 aa)
CDK6Cyclin-dependent kinase 6. (296 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
PSMC226S protease regulatory subunit 7; Belongs to the AAA ATPase family. (464 aa)
PSMC426S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12. (456 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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