STRINGSTRING
RPS27A RPS27A H920_10163 H920_10163 H920_02493 H920_02493 FLRT2 FLRT2 FGFR1 FGFR1 Fgf22 Fgf22 ANOS1 ANOS1 Fgf23 Fgf23 FGF1 FGF1 KL KL Ppp2ca Ppp2ca Frs2 Frs2 Ubc Ubc FGF8 FGF8 Flrt1 Flrt1 MKNK2 MKNK2 MAPK3 MAPK3 PIK3CA PIK3CA MAPK1 MAPK1 PLCG1 PLCG1 FNDC3A FNDC3A SHC1 SHC1 PIK3R1 PIK3R1 CSDE1 CSDE1 UBA52 UBA52 NRAS NRAS Fgf2 Fgf2 ENSFDAP00000000144 ENSFDAP00000000144 PTPN11 PTPN11 SPRED1 SPRED1 BRAF BRAF FGF17 FGF17 Ppp2r1a Ppp2r1a ENSFDAP00000002920 ENSFDAP00000002920 CBL CBL Fgf4 Fgf4 GRB2 GRB2 FRS3 FRS3 FGF20 FGF20 SOS1 SOS1 GAB1 GAB1 SPRED2 SPRED2 FGF6 FGF6 ENSFDAP00000009348 ENSFDAP00000009348 FGF10 FGF10 FNDC3B FNDC3B SPRY2 SPRY2 PPP2CB PPP2CB FGF18 FGF18 FLRT3 FLRT3 SPRY3 SPRY3 HRAS HRAS FGFRL1 FGFRL1 FGF5 FGF5 KRAS KRAS Mknk1 Mknk1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
H920_10163Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (137 aa)
H920_02493Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
FLRT2Leucine-rich repeat transmembrane protein FLRT2. (660 aa)
FGFR1Basic fibroblast growth factor receptor 1. (820 aa)
Fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (95 aa)
ANOS1Anosmin-1. (646 aa)
Fgf23Fibroblast growth factor 23. (129 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
KLKlotho. (969 aa)
Ppp2caSerine/threonine-protein phosphatase. (275 aa)
Frs2Fibroblast growth factor receptor substrate 2. (508 aa)
UbcPolyubiquitin-B. (235 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
Flrt1Leucine-rich repeat transmembrane protein FLRT1. (674 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2. (459 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
FNDC3AFibronectin type-III domain-containing protein 3A. (1198 aa)
SHC1SHC-transforming protein 1. (583 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
CSDE1Cold shock domain-containing protein E1. (798 aa)
UBA52KxDL motif containing 1. (232 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
Fgf2Fibroblast growth factor 2. (129 aa)
ENSFDAP00000000144annotation not available (263 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (600 aa)
SPRED1Sprouty-related, EVH1 domain-containing protein 1. (422 aa)
BRAFSerine/threonine-protein kinase B-raf. (740 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (573 aa)
ENSFDAP00000002920annotation not available (87 aa)
CBLE3 ubiquitin-protein ligase CBL. (851 aa)
Fgf4Fibroblast growth factor 4. (52 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
FRS3Fibroblast growth factor receptor substrate 3. (486 aa)
FGF20Fibroblast growth factor 20. (184 aa)
SOS1Son of sevenless like protein 1. (1289 aa)
GAB1GRB2-associated-binding protein 1. (698 aa)
SPRED2Sprouty-related, EVH1 domain-containing protein 2. (413 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (204 aa)
ENSFDAP00000009348annotation not available (427 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1206 aa)
SPRY2Protein sprouty like protein 2. (315 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FLRT3Leucine-rich repeat transmembrane protein FLRT3. (648 aa)
SPRY3Protein sprouty like protein 3. (288 aa)
HRASHRas proto-oncogene, GTPase. (191 aa)
FGFRL1Fibroblast growth factor receptor-like 1. (476 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (315 aa)
KRASGTPase HRas. (189 aa)
Mknk1MAP kinase-interacting serine/threonine-protein kinase 1; Belongs to the protein kinase superfamily. (415 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.