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| | ATRIP | ATR-interacting protein. (720 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (747 aa) |
| | ENSFDAP00000006648 | annotation not available (129 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | RMI2 | RecQ mediated genome instability 2. (89 aa) |
| | Spidr | Uncharacterized protein. (552 aa) |
| | Rad50 | DNA repair protein RAD50. (1312 aa) |
| | RMI1 | RecQ-mediated genome instability protein 1. (607 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (386 aa) |
| | PALB2 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (1185 aa) |
| | RFC5 | Replication factor C subunit 5. (338 aa) |
| | BRIP1 | Fanconi anemia group J protein. (1161 aa) |
| | TDRD3 | Tudor domain-containing protein 3. (731 aa) |
| | TOPBP1 | DNA topoisomerase 2-binding protein 1. (1526 aa) |
| | NSD2 | Putative histone-lysine N-methyltransferase NSD2. (1366 aa) |
| | ENSFDAP00000001970 | annotation not available (234 aa) |
| | RAD51D | DNA repair protein RAD51 like protein 4. (329 aa) |
| | ENSFDAP00000002085 | annotation not available (112 aa) |
| | DNA2 | DNA2-like helicase. (1059 aa) |
| | ENSFDAP00000002920 | annotation not available (87 aa) |
| | H920_04859 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa) |
| | BLM | Bloom syndrome protein. (1348 aa) |
| | CDK2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | ABRAXAS1 | BRCA1-A complex subunit Abraxas. (359 aa) |
| | ERCC4 | DNA repair endonuclease XPF. (917 aa) |
| | Pold4 | DNA polymerase delta subunit 4. (107 aa) |
| | ERCC1 | DNA excision repair protein ERCC-1. (298 aa) |
| | EME1 | Crossover junction endonuclease EME1. (554 aa) |
| | RAD51B | DNA repair protein RAD51 like protein 2. (258 aa) |
| | LOC104872243 | Histone H4. (103 aa) |
| | RPS27A | Ubiquitin-40S ribosomal protein S27a. (156 aa) |
| | H920_04706 | Histone H2B type 1; Belongs to the histone H2B family. (143 aa) |
| | TP53BP1 | Tumor suppressor p53-binding protein 1. (1958 aa) |
| | LOC104870598 | Histone H2B type 1-K-like. (126 aa) |
| | H2BC21 | Histone H2B; Belongs to the histone H2B family. (137 aa) |
| | BRCA2 | Breast cancer type 2 susceptibility protein. (3134 aa) |
| | CHEK1 | Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa) |
| | CCNA2 | Cyclin A2. (400 aa) |
| | LOC104861338 | Histone H4. (103 aa) |
| | POLH | DNA polymerase eta. (709 aa) |
| | LOC104861347 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC104853831 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | SLF1 | Ankyrin repeat domain-containing protein 32. (1057 aa) |
| | LOC104856844 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC104870592 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RFC4 | Replication factor C subunit 4. (333 aa) |
| | XRCC3 | DNA repair protein XRCC3. (338 aa) |
| | H2BC12 | H2B clustered histone 12. (126 aa) |
| | ENSFDAP00000016636 | annotation not available (103 aa) |
| | CCNA1 | Cyclin-A1; Belongs to the cyclin family. (421 aa) |
| | ENSFDAP00000017292 | annotation not available (27 aa) |
| | ENSFDAP00000017776 | annotation not available (72 aa) |
| | Slx1a | Sulfotransferase; Belongs to the sulfotransferase 1 family. (63 aa) |
| | BARD1 | BRCA1-associated RING domain protein 1. (672 aa) |
| | POLE3 | DNA polymerase epsilon subunit 3. (147 aa) |
| | LOC104870593 | Histone H2B type 1-N. (126 aa) |
| | Ubc | Polyubiquitin-B. (235 aa) |
| | EXD2 | Exonuclease 3'-5' domain-containing protein 2. (617 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa) |
| | CDK3 | Cyclin dependent kinase 3. (297 aa) |
| | POLD1 | DNA polymerase delta 1, catalytic subunit. (933 aa) |
| | Pold3 | DNA polymerase delta subunit 3. (465 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | RHNO1 | Uncharacterized protein. (235 aa) |
| | RECQL4 | ATP-dependent DNA helicase Q4. (1197 aa) |
| | RAD52 | DNA repair protein RAD52 like protein. (294 aa) |
| | LOC104870596 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1737 aa) |
| | Brcc3 | Lys-63-specific deubiquitinase BRCC36. (288 aa) |
| | Babam1 | BRISC and BRCA1 A complex member 1. (293 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (615 aa) |
| | ENSFDAP00000021366 | annotation not available (103 aa) |
| | MRE11 | MRE11 homolog, double strand break repair nuclease. (708 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | H920_00078 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (159 aa) |
| | ENSFDAP00000020651 | annotation not available (191 aa) |
| | LOC104861520 | Histone H2B; Belongs to the histone H2B family. (125 aa) |
| | HERC2 | E3 ubiquitin-protein ligase HERC2. (4835 aa) |
| | WRN | Werner syndrome ATP-dependent helicase. (1439 aa) |
| | LOC104861348 | Histone H4. (103 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (559 aa) |
| | RCBTB2 | RCC1 and BTB domain-containing protein 2. (551 aa) |
| | H920_04415 | BRCA1-A complex subunit RAP80. (415 aa) |
| | SIRT6 | NAD-dependent deacetylase sirtuin-6. (282 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (409 aa) |
| | LOC104871423 | Histone H2B subacrosomal variant; Belongs to the histone H2B family. (122 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa) |
| | H2AX | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | ENSFDAP00000012092 | annotation not available (103 aa) |
| | ATR | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | LOC104861510 | Histone H4. (103 aa) |
| | CLSPN | Claspin. (1338 aa) |
| | ENSFDAP00000011665 | annotation not available (103 aa) |
| | LOC104861527 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC104861523 | Histone H2B type 1. (126 aa) |
| | LOC104861518 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H920_13460 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (74 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | RPA3 | Replication protein A 14 kDa subunit. (122 aa) |
| | LOC104861528 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RFC2 | Replication factor C subunit 2. (316 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (449 aa) |
| | LOC104861529 | Histone H4. (103 aa) |
| | LOC104861522 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (869 aa) |
| | EME2 | Putative crossover junction endonuclease EME2. (371 aa) |
| | RNF169 | RING finger protein 169. (609 aa) |
| | H920_07462 | Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (142 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (404 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (901 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa) |
| | MUS81 | Crossover junction endonuclease MUS81. (539 aa) |
| | TIMELESS | Protein timeless like protein. (1207 aa) |
| | RCBTB1 | RCC1 and BTB domain-containing protein 1. (531 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (991 aa) |
| | RAD51C | DNA repair protein RAD51 like protein 3. (367 aa) |
| | RAD51AP1 | RAD51-associated protein 1. (335 aa) |
| | LOC104861515 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | PPP4R2 | Serine/threonine-protein phosphatase 4 regulatory subunit 2. (403 aa) |
| | RFC1 | Replication factor C subunit 1. (1141 aa) |
| | UBE2I | SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | ANKRD31 | Ankyrin repeat domain-containing protein 31. (1857 aa) |
| | POLD2 | DNA polymerase delta subunit 2. (469 aa) |
| | UBA52 | KxDL motif containing 1. (232 aa) |
| | LOC104861514 | Histone H4. (103 aa) |
| | RAD17 | Cell cycle checkpoint protein RAD17. (714 aa) |
| | UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2. (145 aa) |
| | MEIOB | CDC24_OB3 domain-containing protein. (471 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (411 aa) |
| | RAD1 | Cell cycle checkpoint protein RAD1. (279 aa) |
| | XRCC2 | Actin related protein 3B. (231 aa) |
| | RPA2 | Replication protein A 32 kDa subunit. (270 aa) |
| | POLK | DNA polymerase kappa. (862 aa) |
| | SIRT7 | NAD-dependent deacetylase sirtuin-7. (400 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
