STRINGSTRING
H2BU1 H2BU1 LOC104856844 LOC104856844 LOC104853831 LOC104853831 LOC104861347 LOC104861347 LOC104861338 LOC104861338 H2BC21 H2BC21 LOC104870598 LOC104870598 TP53BP1 TP53BP1 H920_04706 H920_04706 RPS27A RPS27A LOC104872243 LOC104872243 BABAM2 BABAM2 LOC104871423 LOC104871423 ATM ATM H2AX H2AX ENSFDAP00000012092 ENSFDAP00000012092 UBXN1 UBXN1 LOC104861510 LOC104861510 ENSFDAP00000011665 ENSFDAP00000011665 LOC104861527 LOC104861527 TP53 TP53 APBB2 APBB2 SUMO1 SUMO1 UBA52 UBA52 LOC104861514 LOC104861514 UBE2V2 UBE2V2 ENSFDAP00000021366 ENSFDAP00000021366 MRE11 MRE11 H920_00078 H920_00078 LOC104861520 LOC104861520 HERC2 HERC2 LOC104861348 LOC104861348 RNF168 RNF168 H920_04415 H920_04415 EYA2 EYA2 KAT5 KAT5 Ubc Ubc LOC104870593 LOC104870593 BARD1 BARD1 ENSFDAP00000017776 ENSFDAP00000017776 ENSFDAP00000017753 ENSFDAP00000017753 CHEK2 CHEK2 ENSFDAP00000017130 ENSFDAP00000017130 ENSFDAP00000016636 ENSFDAP00000016636 H2BC12 H2BC12 LOC104870592 LOC104870592 Brcc3 Brcc3 Babam1 Babam1 BAP1 BAP1 ABRAXAS1 ABRAXAS1 H920_04859 H920_04859 APBB1 APBB1 ENSFDAP00000002920 ENSFDAP00000002920 ENSFDAP00000002085 ENSFDAP00000002085 ENSFDAP00000001970 ENSFDAP00000001970 NSD2 NSD2 PIAS4 PIAS4 EYA1 EYA1 EYA3 EYA3 Rad50 Rad50 ENSFDAP00000001018 ENSFDAP00000001018 EYA4 EYA4 Kpna2 Kpna2 LOC104861523 LOC104861523 LOC104861518 LOC104861518 PPP5C PPP5C LOC104861528 LOC104861528 RNF8 RNF8 LOC104861529 LOC104861529 LOC104861522 LOC104861522 RNF169 RNF169 H920_07462 H920_07462 ENSFDAP00000008906 ENSFDAP00000008906 LOC104861515 LOC104861515 Kdm4a Kdm4a UBE2I UBE2I ANKRD31 ANKRD31 NBN NBN KDM4B KDM4B ENSFDAP00000006648 ENSFDAP00000006648 LOC104870596 LOC104870596 BRCA1 BRCA1 MAPK8 MAPK8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC104856844Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC104853831Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC104861347Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC104861338Histone H4. (103 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (137 aa)
LOC104870598Histone H2B type 1-K-like. (126 aa)
TP53BP1Tumor suppressor p53-binding protein 1. (1958 aa)
H920_04706Histone H2B type 1; Belongs to the histone H2B family. (143 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
LOC104872243Histone H4. (103 aa)
BABAM2BRISC and BRCA1 A complex member 2. (409 aa)
LOC104871423Histone H2B subacrosomal variant; Belongs to the histone H2B family. (122 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
ENSFDAP00000012092annotation not available (103 aa)
UBXN1UBX domain-containing protein 1. (283 aa)
LOC104861510Histone H4. (103 aa)
ENSFDAP00000011665annotation not available (103 aa)
LOC104861527Histone H2B; Belongs to the histone H2B family. (126 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
APBB2Amyloid beta A4 protein-binding family B member 2. (759 aa)
SUMO1Small ubiquitin-related modifier. (110 aa)
UBA52KxDL motif containing 1. (232 aa)
LOC104861514Histone H4. (103 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
ENSFDAP00000021366annotation not available (103 aa)
MRE11MRE11 homolog, double strand break repair nuclease. (708 aa)
H920_00078Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (159 aa)
LOC104861520Histone H2B; Belongs to the histone H2B family. (125 aa)
HERC2E3 ubiquitin-protein ligase HERC2. (4835 aa)
LOC104861348Histone H4. (103 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (559 aa)
H920_04415BRCA1-A complex subunit RAP80. (415 aa)
EYA2EYA transcriptional coactivator and phosphatase 2. (500 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
UbcPolyubiquitin-B. (235 aa)
LOC104870593Histone H2B type 1-N. (126 aa)
BARD1BRCA1-associated RING domain protein 1. (672 aa)
ENSFDAP00000017776annotation not available (72 aa)
ENSFDAP00000017753annotation not available (63 aa)
CHEK2Serine/threonine-protein kinase Chk2. (549 aa)
ENSFDAP00000017130annotation not available (105 aa)
ENSFDAP00000016636annotation not available (103 aa)
H2BC12H2B clustered histone 12. (126 aa)
LOC104870592Histone H2B; Belongs to the histone H2B family. (126 aa)
Brcc3Lys-63-specific deubiquitinase BRCC36. (288 aa)
Babam1BRISC and BRCA1 A complex member 1. (293 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (729 aa)
ABRAXAS1BRCA1-A complex subunit Abraxas. (359 aa)
H920_04859Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
APBB1Amyloid beta A4 protein-binding family B member 1. (709 aa)
ENSFDAP00000002920annotation not available (87 aa)
ENSFDAP00000002085annotation not available (112 aa)
ENSFDAP00000001970annotation not available (234 aa)
NSD2Putative histone-lysine N-methyltransferase NSD2. (1366 aa)
PIAS4Protein inhibitor of activated STAT 4. (386 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (591 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (572 aa)
Rad50DNA repair protein RAD50. (1312 aa)
ENSFDAP00000001018annotation not available (488 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (616 aa)
Kpna2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
LOC104861523Histone H2B type 1. (126 aa)
LOC104861518Histone H2B; Belongs to the histone H2B family. (126 aa)
PPP5CSerine/threonine-protein phosphatase. (494 aa)
LOC104861528Histone H2B; Belongs to the histone H2B family. (126 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (449 aa)
LOC104861529Histone H4. (103 aa)
LOC104861522Histone H2B; Belongs to the histone H2B family. (126 aa)
RNF169RING finger protein 169. (609 aa)
H920_07462Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
ENSFDAP00000008906annotation not available (463 aa)
LOC104861515Histone H2B; Belongs to the histone H2B family. (126 aa)
Kdm4aLysine-specific demethylase 4A. (1068 aa)
UBE2ISUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
ANKRD31Ankyrin repeat domain-containing protein 31. (1857 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (747 aa)
KDM4BLysine demethylase 4B. (942 aa)
ENSFDAP00000006648annotation not available (129 aa)
LOC104870596Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1737 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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