STRINGSTRING
NBN NBN ATRIP ATRIP ANKRD31 ANKRD31 RFC3 RFC3 H920_13460 H920_13460 LOC104861518 LOC104861518 LOC104861523 LOC104861523 LOC104861527 LOC104861527 ENSFDAP00000011665 ENSFDAP00000011665 CLSPN CLSPN LOC104861510 LOC104861510 ATR ATR ENSFDAP00000012092 ENSFDAP00000012092 H2AX H2AX ATM ATM LOC104871423 LOC104871423 BABAM2 BABAM2 LOC104872243 LOC104872243 H920_04706 H920_04706 TP53BP1 TP53BP1 LOC104870598 LOC104870598 H2BC21 H2BC21 CCNA2 CCNA2 LOC104861338 LOC104861338 LOC104861347 LOC104861347 LOC104853831 LOC104853831 LOC104856844 LOC104856844 H2BU1 H2BU1 LOC104870592 LOC104870592 RFC4 RFC4 H2BC12 H2BC12 ENSFDAP00000016636 ENSFDAP00000016636 CCNA1 CCNA1 ENSFDAP00000017776 ENSFDAP00000017776 BARD1 BARD1 LOC104870593 LOC104870593 KAT5 KAT5 CDK3 CDK3 SIRT6 SIRT6 H920_04415 H920_04415 RCBTB2 RCBTB2 RNF168 RNF168 LOC104861348 LOC104861348 WRN WRN HERC2 HERC2 LOC104861520 LOC104861520 ENSFDAP00000020651 ENSFDAP00000020651 H920_00078 H920_00078 MRE11 MRE11 ENSFDAP00000021366 ENSFDAP00000021366 UBE2I UBE2I PPP4R2 PPP4R2 LOC104861515 LOC104861515 TOP3A TOP3A RCBTB1 RCBTB1 TIMELESS TIMELESS RBBP8 RBBP8 RAD9B RAD9B H920_07462 H920_07462 RNF169 RNF169 LOC104861522 LOC104861522 RPA2 RPA2 HUS1 HUS1 CHEK1 CHEK1 Rad50 Rad50 RMI1 RMI1 TOPBP1 TOPBP1 NSD2 NSD2 RNF8 RNF8 ENSFDAP00000001970 ENSFDAP00000001970 ENSFDAP00000002085 ENSFDAP00000002085 DNA2 DNA2 H920_04859 H920_04859 BLM BLM LOC104861529 LOC104861529 CDK2 CDK2 RAD17 RAD17 LOC104861514 LOC104861514 ABRAXAS1 ABRAXAS1 Babam1 Babam1 UBE2V2 UBE2V2 RAD9A RAD9A RAD1 RAD1 RPA1 RPA1 RFC5 RFC5 PIAS4 PIAS4 BRIP1 BRIP1 RPA3 RPA3 LOC104861528 LOC104861528 RFC2 RFC2 Brcc3 Brcc3 BRCA1 BRCA1 LOC104870596 LOC104870596 RECQL4 RECQL4 RHNO1 RHNO1 RMI2 RMI2 PPP4C PPP4C ENSFDAP00000006648 ENSFDAP00000006648
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (747 aa)
ATRIPATR-interacting protein. (720 aa)
ANKRD31Ankyrin repeat domain-containing protein 31. (1857 aa)
RFC3Replication factor C subunit 3. (356 aa)
H920_13460TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (74 aa)
LOC104861518Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC104861523Histone H2B type 1. (126 aa)
LOC104861527Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSFDAP00000011665annotation not available (103 aa)
CLSPNClaspin. (1338 aa)
LOC104861510Histone H4. (103 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa)
ENSFDAP00000012092annotation not available (103 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa)
LOC104871423Histone H2B subacrosomal variant; Belongs to the histone H2B family. (122 aa)
BABAM2BRISC and BRCA1 A complex member 2. (409 aa)
LOC104872243Histone H4. (103 aa)
H920_04706Histone H2B type 1; Belongs to the histone H2B family. (143 aa)
TP53BP1Tumor suppressor p53-binding protein 1. (1958 aa)
LOC104870598Histone H2B type 1-K-like. (126 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (137 aa)
CCNA2Cyclin A2. (400 aa)
LOC104861338Histone H4. (103 aa)
LOC104861347Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC104853831Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC104856844Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC104870592Histone H2B; Belongs to the histone H2B family. (126 aa)
RFC4Replication factor C subunit 4. (333 aa)
H2BC12H2B clustered histone 12. (126 aa)
ENSFDAP00000016636annotation not available (103 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (421 aa)
ENSFDAP00000017776annotation not available (72 aa)
BARD1BRCA1-associated RING domain protein 1. (672 aa)
LOC104870593Histone H2B type 1-N. (126 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
CDK3Cyclin dependent kinase 3. (297 aa)
SIRT6NAD-dependent deacetylase sirtuin-6. (282 aa)
H920_04415BRCA1-A complex subunit RAP80. (415 aa)
RCBTB2RCC1 and BTB domain-containing protein 2. (551 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (559 aa)
LOC104861348Histone H4. (103 aa)
WRNWerner syndrome ATP-dependent helicase. (1439 aa)
HERC2E3 ubiquitin-protein ligase HERC2. (4835 aa)
LOC104861520Histone H2B; Belongs to the histone H2B family. (125 aa)
ENSFDAP00000020651annotation not available (191 aa)
H920_00078Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (159 aa)
MRE11MRE11 homolog, double strand break repair nuclease. (708 aa)
ENSFDAP00000021366annotation not available (103 aa)
UBE2ISUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
PPP4R2Serine/threonine-protein phosphatase 4 regulatory subunit 2. (403 aa)
LOC104861515Histone H2B; Belongs to the histone H2B family. (126 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (991 aa)
RCBTB1RCC1 and BTB domain-containing protein 1. (531 aa)
TIMELESSProtein timeless like protein. (1207 aa)
RBBP8RB binding protein 8, endonuclease. (901 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (404 aa)
H920_07462Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
RNF169RING finger protein 169. (609 aa)
LOC104861522Histone H2B; Belongs to the histone H2B family. (126 aa)
RPA2Replication protein A 32 kDa subunit. (270 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
CHEK1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa)
Rad50DNA repair protein RAD50. (1312 aa)
RMI1RecQ-mediated genome instability protein 1. (607 aa)
TOPBP1DNA topoisomerase 2-binding protein 1. (1526 aa)
NSD2Putative histone-lysine N-methyltransferase NSD2. (1366 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (449 aa)
ENSFDAP00000001970annotation not available (234 aa)
ENSFDAP00000002085annotation not available (112 aa)
DNA2DNA2-like helicase. (1059 aa)
H920_04859Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
BLMBloom syndrome protein. (1348 aa)
LOC104861529Histone H4. (103 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
RAD17Cell cycle checkpoint protein RAD17. (714 aa)
LOC104861514Histone H4. (103 aa)
ABRAXAS1BRCA1-A complex subunit Abraxas. (359 aa)
Babam1BRISC and BRCA1 A complex member 1. (293 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (411 aa)
RAD1Cell cycle checkpoint protein RAD1. (279 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (615 aa)
RFC5Replication factor C subunit 5. (338 aa)
PIAS4Protein inhibitor of activated STAT 4. (386 aa)
BRIP1Fanconi anemia group J protein. (1161 aa)
RPA3Replication protein A 14 kDa subunit. (122 aa)
LOC104861528Histone H2B; Belongs to the histone H2B family. (126 aa)
RFC2Replication factor C subunit 2. (316 aa)
Brcc3Lys-63-specific deubiquitinase BRCC36. (288 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1737 aa)
LOC104870596Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
RECQL4ATP-dependent DNA helicase Q4. (1197 aa)
RHNO1Uncharacterized protein. (235 aa)
RMI2RecQ mediated genome instability 2. (89 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
ENSFDAP00000006648annotation not available (129 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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