STRINGSTRING
CHEK2 CHEK2 MDM4 MDM4 ENSFDAP00000023027 ENSFDAP00000023027 MAPKAPK5 MAPKAPK5 H920_09835 H920_09835 UBA52 UBA52 RAD17 RAD17 MEIOB MEIOB RAD9A RAD9A RAD1 RAD1 RPA1 RPA1 MRE11 MRE11 Mdm2 Mdm2 H920_00078 H920_00078 Ly6g5b Ly6g5b TAF5 TAF5 PLK3 PLK3 SUPT16H SUPT16H HIPK4 HIPK4 ENSFDAP00000020651 ENSFDAP00000020651 CSNK2B CSNK2B PRKAB1 PRKAB1 TAF15 TAF15 WRN WRN TAF13 TAF13 TAF9 TAF9 CDK3 CDK3 KAT5 KAT5 HIPK1 HIPK1 EXD2 EXD2 Ubc Ubc PRKAA2 PRKAA2 BARD1 BARD1 ENSFDAP00000018123 ENSFDAP00000018123 Taf1 Taf1 Cdk5 Cdk5 CCNA1 CCNA1 RFC4 RFC4 PRKAG3 PRKAG3 TP53INP2 TP53INP2 TAF7L TAF7L SLF1 SLF1 TAF4B TAF4B TAF10 TAF10 CCNA2 CCNA2 NUAK2 NUAK2 SSRP1 SSRP1 RPS27A RPS27A HIPK2 HIPK2 AURKC AURKC ATM ATM TAF9B TAF9B ATR ATR ENSFDAP00000011804 ENSFDAP00000011804 TP53 TP53 CDK5R1 CDK5R1 RFC3 RFC3 RPA3 RPA3 RFC2 RFC2 MAPK11 MAPK11 TAF11 TAF11 TAF2 TAF2 RAD9B RAD9B NOC2L NOC2L RBBP8 RBBP8 TAF4 TAF4 Csnk2a1 Csnk2a1 TOP3A TOP3A TBP TBP NUAK1 NUAK1 PRKAG2 PRKAG2 ANKRD31 ANKRD31 ATRIP ATRIP TAF12 TAF12 TP53RK TP53RK NBN NBN RMI2 RMI2 PRKAG1 PRKAG1 TBPL1 TBPL1 RHNO1 RHNO1 RECQL4 RECQL4 CSNK2A2 CSNK2A2 TAF6 TAF6 TAF3 TAF3 MAPK14 MAPK14 DYRK2 DYRK2 BRCA1 BRCA1 TP53INP1 TP53INP1 STK11 STK11 PRKAB2 PRKAB2 AURKA AURKA CDK2 CDK2 BLM BLM ENSFDAP00000002920 ENSFDAP00000002920 Tpx2 Tpx2 DYRK3 DYRK3 Taf7 Taf7 DNA2 DNA2 DYRK4 DYRK4 PRKAA1 PRKAA1 TOPBP1 TOPBP1 H920_05032 H920_05032 AURKB AURKB TDRD3 TDRD3 BRIP1 BRIP1 RFC5 RFC5 RMI1 RMI1 Rad50 Rad50 CHEK1 CHEK1 ENSFDAP00000000529 ENSFDAP00000000529 HUS1 HUS1 HIPK3 HIPK3 RPA2 RPA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHEK2Serine/threonine-protein kinase Chk2. (549 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (492 aa)
ENSFDAP00000023027annotation not available (658 aa)
MAPKAPK5MAP kinase-activated protein kinase 5. (476 aa)
H920_09835Serine/threonine-protein kinase PLK5. (486 aa)
UBA52KxDL motif containing 1. (232 aa)
RAD17Cell cycle checkpoint protein RAD17. (714 aa)
MEIOBCDC24_OB3 domain-containing protein. (471 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (411 aa)
RAD1Cell cycle checkpoint protein RAD1. (279 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (615 aa)
MRE11MRE11 homolog, double strand break repair nuclease. (708 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2. (504 aa)
H920_00078Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (159 aa)
Ly6g5bUncharacterized protein. (193 aa)
TAF5Transcription initiation factor TFIID subunit 5. (646 aa)
PLK3Serine/threonine-protein kinase PLK3. (579 aa)
SUPT16HFACT complex subunit SPT16. (1047 aa)
HIPK4Homeodomain-interacting protein kinase 4. (615 aa)
ENSFDAP00000020651annotation not available (191 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (183 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
TAF15TATA-binding protein-associated factor 2N. (553 aa)
WRNWerner syndrome ATP-dependent helicase. (1439 aa)
TAF13Transcription initiation factor TFIID subunit 13. (124 aa)
TAF9TATA-box binding protein associated factor 9. (263 aa)
CDK3Cyclin dependent kinase 3. (297 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
HIPK1Homeodomain-interacting protein kinase 1. (1211 aa)
EXD2Exonuclease 3'-5' domain-containing protein 2. (617 aa)
UbcPolyubiquitin-B. (235 aa)
PRKAA2Non-specific serine/threonine protein kinase. (545 aa)
BARD1BRCA1-associated RING domain protein 1. (672 aa)
ENSFDAP00000018123annotation not available (101 aa)
Taf1Transcription initiation factor TFIID subunit 1. (1856 aa)
Cdk5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (421 aa)
RFC4Replication factor C subunit 4. (333 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (488 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (188 aa)
TAF7LTATA-box binding protein associated factor 7 like. (371 aa)
SLF1Ankyrin repeat domain-containing protein 32. (1057 aa)
TAF4BTranscription initiation factor TFIID subunit 4B. (730 aa)
TAF10Transcription initiation factor TFIID subunit 10. (175 aa)
CCNA2Cyclin A2. (400 aa)
NUAK2NUAK family SNF1-like kinase 2. (589 aa)
SSRP1FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (710 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
HIPK2Homeodomain-interacting protein kinase 2. (1194 aa)
AURKCZinc finger protein 548. (279 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa)
TAF9BTranscription initiation factor TFIID subunit 9B. (260 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa)
ENSFDAP00000011804annotation not available (202 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
RFC3Replication factor C subunit 3. (356 aa)
RPA3Replication protein A 14 kDa subunit. (122 aa)
RFC2Replication factor C subunit 2. (316 aa)
MAPK11Mitogen-activated protein kinase 11. (325 aa)
TAF11Transcription initiation factor TFIID subunit 11. (211 aa)
TAF2Transcription initiation factor TFIID subunit 2. (1214 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (404 aa)
NOC2LNucleolar complex protein 2 like protein. (750 aa)
RBBP8RB binding protein 8, endonuclease. (901 aa)
TAF4TATA-box binding protein associated factor 4. (620 aa)
Csnk2a1Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (391 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (991 aa)
TBPTATA-box-binding protein. (321 aa)
NUAK1NUAK family SNF1-like kinase 1. (399 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2. (541 aa)
ANKRD31Ankyrin repeat domain-containing protein 31. (1857 aa)
ATRIPATR-interacting protein. (720 aa)
TAF12Transcription initiation factor TFIID subunit 12. (213 aa)
TP53RKTP53 regulating kinase. (201 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (747 aa)
RMI2RecQ mediated genome instability 2. (89 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1. (330 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
RHNO1Uncharacterized protein. (235 aa)
RECQL4ATP-dependent DNA helicase Q4. (1197 aa)
CSNK2A2Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (315 aa)
TAF6Transcription initiation factor TFIID subunit 6. (676 aa)
TAF3Transcription initiation factor TFIID subunit 3. (770 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2. (540 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1737 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (243 aa)
STK11Serine/threonine-protein kinase 11; Belongs to the protein kinase superfamily. (434 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (257 aa)
AURKAAurora kinase A. (401 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
BLMBloom syndrome protein. (1348 aa)
ENSFDAP00000002920annotation not available (87 aa)
Tpx2Targeting protein for Xklp2. (749 aa)
DYRK3Dual specificity tyrosine-phosphorylation-regulated kinase 3. (562 aa)
Taf7Transcription initiation factor TFIID subunit 7. (341 aa)
DNA2DNA2-like helicase. (1059 aa)
DYRK4Dual specificity tyrosine-phosphorylation-regulated kinase 4. (642 aa)
PRKAA1Non-specific serine/threonine protein kinase. (516 aa)
TOPBP1DNA topoisomerase 2-binding protein 1. (1526 aa)
H920_05032Targeting protein for Xklp2. (620 aa)
AURKBSerine/threonine-protein kinase 12; Belongs to the protein kinase superfamily. (339 aa)
TDRD3Tudor domain-containing protein 3. (731 aa)
BRIP1Fanconi anemia group J protein. (1161 aa)
RFC5Replication factor C subunit 5. (338 aa)
RMI1RecQ-mediated genome instability protein 1. (607 aa)
Rad50DNA repair protein RAD50. (1312 aa)
CHEK1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa)
ENSFDAP00000000529annotation not available (261 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
HIPK3Homeodomain-interacting protein kinase 3. (1219 aa)
RPA2Replication protein A 32 kDa subunit. (270 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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