STRINGSTRING
PPP2R1B PPP2R1B MDM4 MDM4 AKT2 AKT2 UBA52 UBA52 Mdm2 Mdm2 ENSFDAP00000020570 ENSFDAP00000020570 CDK3 CDK3 TXNDC11 TXNDC11 Ubc Ubc PPP2R5C PPP2R5C Ppp2ca Ppp2ca CHEK2 CHEK2 CCNA1 CCNA1 MAPKAP1 MAPKAP1 PHF20 PHF20 MTOR MTOR Ccng1 Ccng1 CDK1 CDK1 CCNA2 CCNA2 ENSFDAP00000015072 ENSFDAP00000015072 H920_02493 H920_02493 RPS27A RPS27A ATM ATM ENSFDAP00000012795 ENSFDAP00000012795 RNF34 RNF34 ENSFDAP00000011804 ENSFDAP00000011804 TP53 TP53 PPP2CB PPP2CB AKT3 AKT3 RICTOR RICTOR USP7 USP7 DAXX DAXX AKT1 AKT1 USP2 USP2 PDPK1 PDPK1 CDK2 CDK2 ENSFDAP00000002920 ENSFDAP00000002920 RFFL RFFL Ppp2r1a Ppp2r1a H920_00545 H920_00545 SGK1 SGK1 MLST8 MLST8 ENSFDAP00000000144 ENSFDAP00000000144
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (653 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (492 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
UBA52KxDL motif containing 1. (232 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2. (504 aa)
ENSFDAP00000020570annotation not available (269 aa)
CDK3Cyclin dependent kinase 3. (297 aa)
TXNDC11Thioredoxin domain-containing protein 11. (866 aa)
UbcPolyubiquitin-B. (235 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa)
Ppp2caSerine/threonine-protein phosphatase. (275 aa)
CHEK2Serine/threonine-protein kinase Chk2. (549 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (421 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
PHF20PHD finger protein 20. (1008 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2551 aa)
Ccng1Cyclin-G1; Belongs to the cyclin family. (294 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
CCNA2Cyclin A2. (400 aa)
ENSFDAP00000015072annotation not available (241 aa)
H920_02493Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa)
ENSFDAP00000012795annotation not available (271 aa)
RNF34E3 ubiquitin-protein ligase RNF34. (373 aa)
ENSFDAP00000011804annotation not available (202 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
AKT3Non-specific serine/threonine protein kinase. (480 aa)
RICTORRapamycin-insensitive companion of mTOR. (1708 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1086 aa)
DAXXDeath domain-associated protein 6. (684 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (612 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (558 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
ENSFDAP00000002920annotation not available (87 aa)
RFFLE3 ubiquitin-protein ligase rififylin. (366 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (573 aa)
H920_00545Cyclin-G1; Belongs to the cyclin family. (281 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
MLST8Target of rapamycin complex subunit LST8. (326 aa)
ENSFDAP00000000144annotation not available (263 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.