STRINGSTRING
AKT2 AKT2 MDM4 MDM4 PDPK1 PDPK1 ENSFDAP00000011804 ENSFDAP00000011804 TP53 TP53 PPP2CB PPP2CB AKT3 AKT3 CDK2 CDK2 ENSFDAP00000002920 ENSFDAP00000002920 RFFL RFFL Ppp2r1a Ppp2r1a H920_00545 H920_00545 SGK1 SGK1 MLST8 MLST8 ENSFDAP00000000144 ENSFDAP00000000144 USP2 USP2 RICTOR RICTOR USP7 USP7 DAXX DAXX PRDM1 PRDM1 AKT1 AKT1 RNF34 RNF34 ENSFDAP00000012795 ENSFDAP00000012795 ATM ATM RPS27A RPS27A H920_02493 H920_02493 ENSFDAP00000015072 ENSFDAP00000015072 CCNA2 CCNA2 CDK1 CDK1 Ccng1 Ccng1 MTOR MTOR PHF20 PHF20 MAPKAP1 MAPKAP1 CCNA1 CCNA1 CHEK2 CHEK2 Ppp2ca Ppp2ca PPP2R5C PPP2R5C Ubc Ubc PPP2R1B PPP2R1B TXNDC11 TXNDC11 CDK3 CDK3 ENSFDAP00000020570 ENSFDAP00000020570 Mdm2 Mdm2 UBA52 UBA52
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (492 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (558 aa)
ENSFDAP00000011804annotation not available (202 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
AKT3Non-specific serine/threonine protein kinase. (480 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
ENSFDAP00000002920annotation not available (87 aa)
RFFLE3 ubiquitin-protein ligase rififylin. (366 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (573 aa)
H920_00545Cyclin-G1; Belongs to the cyclin family. (281 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
MLST8Target of rapamycin complex subunit LST8. (326 aa)
ENSFDAP00000000144annotation not available (263 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (612 aa)
RICTORRapamycin-insensitive companion of mTOR. (1708 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7; Belongs to the peptidase C19 family. (1086 aa)
DAXXDeath domain-associated protein 6. (684 aa)
PRDM1PR/SET domain 1. (849 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RNF34E3 ubiquitin-protein ligase RNF34. (373 aa)
ENSFDAP00000012795annotation not available (271 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
H920_02493Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
ENSFDAP00000015072annotation not available (241 aa)
CCNA2Cyclin A2. (400 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
Ccng1Cyclin-G1; Belongs to the cyclin family. (294 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2551 aa)
PHF20PHD finger protein 20. (1008 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (421 aa)
CHEK2Serine/threonine-protein kinase Chk2. (549 aa)
Ppp2caSerine/threonine-protein phosphatase. (275 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa)
UbcPolyubiquitin-B. (235 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (653 aa)
TXNDC11Thioredoxin domain-containing protein 11. (866 aa)
CDK3Cyclin dependent kinase 3. (297 aa)
ENSFDAP00000020570annotation not available (269 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2. (504 aa)
UBA52KxDL motif containing 1. (232 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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