STRINGSTRING
RPA2 RPA2 SKP2 SKP2 PSMB3 PSMB3 MCM10 MCM10 ORC6 ORC6 Tm4sf19 Tm4sf19 Cables1 Cables1 POLE POLE CKS2 CKS2 CDC7 CDC7 PSMC6 PSMC6 ORC5 ORC5 PSME2 PSME2 ENSFDAP00000010230 ENSFDAP00000010230 PPP4R1 PPP4R1 POLA1 POLA1 PSMD3 PSMD3 AKT3 AKT3 PPP2CB PPP2CB MCM2 MCM2 RPA3 RPA3 PSMB7 PSMB7 H920_05040 H920_05040 MCM4 MCM4 PSMC5 PSMC5 PSMA4 PSMA4 PPP2R3A PPP2R3A H920_07431 H920_07431 PTK6 PTK6 PSMD14 PSMD14 PSMA2 PSMA2 RPS27A RPS27A H920_02493 H920_02493 FNBP4 FNBP4 PSMA6 PSMA6 CDK7 CDK7 PSMB10 PSMB10 CKS1B CKS1B PSMD5 PSMD5 CCNA2 CCNA2 H920_20354 H920_20354 PSMB5 PSMB5 LOC104868352 LOC104868352 MCM6 MCM6 PSMB1 PSMB1 Mcm8 Mcm8 ORC4 ORC4 PSMB9 PSMB9 DBF4 DBF4 CCNA1 CCNA1 Ppp2ca Ppp2ca H920_15675 H920_15675 POLE3 POLE3 H920_01229 H920_01229 Prim1 Prim1 Ubc Ubc PPP2R1B PPP2R1B Psmd9 Psmd9 CDK3 CDK3 RELCH RELCH Cdkn1c Cdkn1c PSMD6 PSMD6 MCM9 MCM9 WEE2 WEE2 PSME1 PSME1 CUL1 CUL1 PSMD2 PSMD2 PSMB2 PSMB2 KIAA2012 KIAA2012 PSMC1 PSMC1 PSMA1 PSMA1 CDC45 CDC45 POLE2 POLE2 LOC104865314 LOC104865314 WEE1 WEE1 CDKN1B CDKN1B Ppp2r1a Ppp2r1a CDKN1A CDKN1A CDC6 CDC6 ENSFDAP00000002920 ENSFDAP00000002920 PRIM2 PRIM2 CDK2 CDK2 PSMD7 PSMD7 AKT1 AKT1 PSMD13 PSMD13 CREBZF CREBZF PSMD10 PSMD10 MCM5 MCM5 PSMF1 PSMF1 GMNN GMNN PSMD4 PSMD4 ORC1 ORC1 PSMB4 PSMB4 PSME3 PSME3 CCNE1 CCNE1 CDT1 CDT1 PPP4R4 PPP4R4 RPA1 RPA1 CCNH CCNH MEIOB MEIOB PSMA7 PSMA7 UBA52 UBA52 ORC2 ORC2 SKP1 SKP1 Pola2 Pola2 PSMA3 PSMA3 PSMD12 PSMD12 PSMC4 PSMC4 PSMC2 PSMC2 AKT2 AKT2 PSMD11 PSMD11 PSMB6 PSMB6 ORC3 ORC3 PSMC3 PSMC3 PSMD8 PSMD8 Mcm7 Mcm7 CDK4 CDK4 MCM3 MCM3 CCND1 CCND1 PPP2R3C PPP2R3C PSMA5 PSMA5 RB1 RB1 MNAT1 MNAT1 CCNE2 CCNE2 PSMD1 PSMD1 ENSFDAP00000000144 ENSFDAP00000000144
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA2Replication protein A 32 kDa subunit. (270 aa)
SKP2S-phase kinase-associated protein 2. (424 aa)
PSMB3Proteasome subunit beta. (205 aa)
MCM10Protein MCM10 like protein. (874 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
Tm4sf19Transmembrane 4 L6 family member 19. (181 aa)
Cables1CDK5 and ABL1 enzyme substrate 1. (305 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa)
CKS2CDC28 protein kinase regulatory subunit 2. (79 aa)
CDC7Cell division cycle 7-related protein kinase. (571 aa)
PSMC626S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (389 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
PSME2Proteasome activator complex subunit 2. (239 aa)
ENSFDAP00000010230annotation not available (709 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (928 aa)
POLA1DNA polymerase. (1462 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (331 aa)
AKT3Non-specific serine/threonine protein kinase. (480 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
RPA3Replication protein A 14 kDa subunit. (122 aa)
PSMB7Proteasome subunit beta type-7. (277 aa)
H920_05040Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (97 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
PSMC526S protease regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa)
PSMA4Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (210 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha. (1151 aa)
H920_07431S-phase kinase-associated protein 1; Belongs to the SKP1 family. (136 aa)
PTK6Protein-tyrosine kinase 6. (451 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
H920_02493Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
FNBP4Formin binding protein 4. (916 aa)
PSMA6Proteasome subunit alpha type. (247 aa)
CDK7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
PSMB10Proteasome subunit beta. (273 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5. (504 aa)
CCNA2Cyclin A2. (400 aa)
H920_20354S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
PSMB5Proteasome subunit beta. (263 aa)
LOC104868352Glycine N-acyltransferase. (295 aa)
MCM6DNA helicase; Belongs to the MCM family. (786 aa)
PSMB1Proteasome subunit beta. (240 aa)
Mcm8DNA replication licensing factor MCM8; Belongs to the MCM family. (833 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
PSMB9Proteasome subunit beta type-9. (219 aa)
DBF4Protein DBF4 like protein A. (636 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (421 aa)
Ppp2caSerine/threonine-protein phosphatase. (275 aa)
H920_15675S-phase kinase-associated protein 1; Belongs to the SKP1 family. (135 aa)
POLE3DNA polymerase epsilon subunit 3. (147 aa)
H920_01229Cullin-1; Belongs to the cullin family. (265 aa)
Prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
UbcPolyubiquitin-B. (235 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (653 aa)
Psmd926S proteasome non-ATPase regulatory subunit 9. (223 aa)
CDK3Cyclin dependent kinase 3. (297 aa)
RELCHLisH domain and HEAT repeat-containing protein KIAA1468. (1216 aa)
Cdkn1cCyclin-dependent kinase inhibitor 1C. (127 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6. (340 aa)
MCM9DNA replication licensing factor MCM9; Belongs to the MCM family. (1106 aa)
WEE2Wee1-like protein kinase 2. (511 aa)
PSME1Proteasome activator complex subunit 1. (249 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
PSMD2Proteasome 26S subunit, non-ATPase 2. (908 aa)
PSMB2Proteasome subunit beta. (201 aa)
KIAA2012Uncharacterized protein. (1178 aa)
PSMC126S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
PSMA1Proteasome subunit alpha type-1. (264 aa)
CDC45Cell division control protein 45 like protein. (566 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
LOC104865314Serine/threonine-protein phosphatase 4 regulatory subunit 1. (941 aa)
WEE1Zinc finger protein 143. (470 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (573 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (165 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa)
ENSFDAP00000002920annotation not available (87 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (506 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (324 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
CREBZFCREB/ATF bZIP transcription factor. (307 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10. (226 aa)
MCM5DNA helicase; Belongs to the MCM family. (678 aa)
PSMF1Proteasome inhibitor PI31 subunit. (271 aa)
GMNNGeminin. (208 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4. (379 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (828 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa)
PSME3Proteasome activator complex subunit 3. (265 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (405 aa)
CDT1DNA replication factor Cdt1. (542 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4. (833 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (615 aa)
CCNHCyclin-H; Belongs to the cyclin family. (323 aa)
MEIOBCDC24_OB3 domain-containing protein. (471 aa)
PSMA7Proteasome endopeptidase complex. (216 aa)
UBA52KxDL motif containing 1. (232 aa)
ORC2Origin recognition complex subunit 2. (599 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (188 aa)
Pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12. (456 aa)
PSMC426S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
PSMC226S protease regulatory subunit 7; Belongs to the AAA ATPase family. (464 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (391 aa)
PSMB6Proteasome subunit beta. (239 aa)
ORC3Origin recognition complex subunit 3. (720 aa)
PSMC326S protease regulatory subunit 6A. (440 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (350 aa)
Mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MCM3DNA helicase; Belongs to the MCM family. (817 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
PPP2R3CSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma. (453 aa)
PSMA5Proteasome 20S subunit alpha 5. (241 aa)
RB1Retinoblastoma-associated protein. (882 aa)
MNAT1CDK-activating kinase assembly factor MAT1. (309 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (405 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1. (953 aa)
ENSFDAP00000000144annotation not available (263 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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