STRINGSTRING
UBE2D1 UBE2D1 RBX1 RBX1 AKT2 AKT2 PSMC2 PSMC2 SMC1A SMC1A PSMC4 PSMC4 PSMD12 PSMD12 PSMA3 PSMA3 Pola2 Pola2 SKP1 SKP1 POLD2 POLD2 ORC2 ORC2 UBA52 UBA52 PSMA7 PSMA7 MEIOB MEIOB CCNH CCNH RPA1 RPA1 CDKN1B CDKN1B WEE1 WEE1 POLE2 POLE2 PSMA1 PSMA1 LIG1 LIG1 UBE2C UBE2C PSMC1 PSMC1 CUL1 CUL1 PDS5B PDS5B RCBTB2 RCBTB2 PSME1 PSME1 WEE2 WEE2 MCM9 MCM9 PSMD6 PSMD6 Pold3 Pold3 POLD1 POLD1 Cdkn1c Cdkn1c CDK3 CDK3 Psmd9 Psmd9 Esco1 Esco1 Ubc Ubc Prim1 Prim1 H920_01229 H920_01229 POLE3 POLE3 H920_15675 H920_15675 CDC27 CDC27 UBE2E1 UBE2E1 GINS4 GINS4 RAD21 RAD21 CCNA1 CCNA1 PSMB9 PSMB9 ORC4 ORC4 Mcm8 Mcm8 RAD21L1 RAD21L1 RFC4 RFC4 ANAPC16 ANAPC16 TM7SF3 TM7SF3 ENSFDAP00000015944 ENSFDAP00000015944 PSMB1 PSMB1 STAG1 STAG1 MCM6 MCM6 LOC104868352 LOC104868352 PSMB5 PSMB5 ANAPC15 ANAPC15 H920_20354 H920_20354 CCNA2 CCNA2 PSMD5 PSMD5 GINS2 GINS2 CKS1B CKS1B PSMB10 PSMB10 CDK7 CDK7 PSMA6 PSMA6 RPS27A RPS27A ANAPC4 ANAPC4 PSMA2 PSMA2 PSMD14 PSMD14 PTK6 PTK6 ANAPC10 ANAPC10 Pold4 Pold4 UBE2S UBE2S H920_07431 H920_07431 PSMA4 PSMA4 PSMC5 PSMC5 PSMA8 PSMA8 Fen1 Fen1 PDS5A PDS5A MCM4 MCM4 H920_05040 H920_05040 RFC3 RFC3 PSMB7 PSMB7 RPA3 RPA3 MCM2 MCM2 RFC2 RFC2 AKT3 AKT3 CDCA5 CDCA5 PSMD3 PSMD3 POLA1 POLA1 WAPL WAPL Fam89b Fam89b ENSFDAP00000010230 ENSFDAP00000010230 PSME2 PSME2 ORC5 ORC5 PSMC6 PSMC6 TCERG1L TCERG1L GINS3 GINS3 PSME4 PSME4 CKS2 CKS2 POLE POLE Cables1 Cables1 Tm4sf19 Tm4sf19 RCBTB1 RCBTB1 Anapc11 Anapc11 ANAPC7 ANAPC7 KIAA2012 KIAA2012 PSMB2 PSMB2 PSMD2 PSMD2 SMC3 SMC3 SKP2 SKP2 ANAPC1 ANAPC1 PSMB3 PSMB3 RFC1 RFC1 ORC6 ORC6 CDT1 CDT1 CCNE1 CCNE1 CDC26 CDC26 PSME3 PSME3 ATAD5 ATAD5 PSMB4 PSMB4 ESCO2 ESCO2 ORC1 ORC1 PSMD4 PSMD4 ANAPC5 ANAPC5 GMNN GMNN PSMF1 PSMF1 MCM5 MCM5 PSMD10 PSMD10 CREBZF CREBZF CDC16 CDC16 PSMD13 PSMD13 AKT1 AKT1 PSMD7 PSMD7 ANAPC2 ANAPC2 CDK2 CDK2 FZR1 FZR1 PRIM2 PRIM2 ENSFDAP00000002920 ENSFDAP00000002920 CDC6 CDC6 STAG2 STAG2 CDKN1A CDKN1A DNA2 DNA2 GINS1 GINS1 PSMD11 PSMD11 PSMB6 PSMB6 ORC3 ORC3 PSMC3 PSMC3 PSMD8 PSMD8 CDC23 CDC23 RFC5 RFC5 Mcm7 Mcm7 CDK4 CDK4 MCM3 MCM3 CCND1 CCND1 CDC25B CDC25B PCNA PCNA PSMA5 PSMA5 RB1 RB1 MNAT1 MNAT1 CCNE2 CCNE2 PSMD1 PSMD1 RPA2 RPA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UBE2D1Ubiquitin-conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (140 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (108 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
PSMC226S protease regulatory subunit 7; Belongs to the AAA ATPase family. (464 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
PSMC426S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12. (456 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
Pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (188 aa)
POLD2DNA polymerase delta subunit 2. (469 aa)
ORC2Origin recognition complex subunit 2. (599 aa)
UBA52KxDL motif containing 1. (232 aa)
PSMA7Proteasome endopeptidase complex. (216 aa)
MEIOBCDC24_OB3 domain-containing protein. (471 aa)
CCNHCyclin-H; Belongs to the cyclin family. (323 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (615 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
WEE1Zinc finger protein 143. (470 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
PSMA1Proteasome subunit alpha type-1. (264 aa)
LIG1DNA ligase. (916 aa)
UBE2CUbiquitin-conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
PSMC126S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
PDS5BPDS5 cohesin associated factor B. (1448 aa)
RCBTB2RCC1 and BTB domain-containing protein 2. (551 aa)
PSME1Proteasome activator complex subunit 1. (249 aa)
WEE2Wee1-like protein kinase 2. (511 aa)
MCM9DNA replication licensing factor MCM9; Belongs to the MCM family. (1106 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6. (340 aa)
Pold3DNA polymerase delta subunit 3. (465 aa)
POLD1DNA polymerase delta 1, catalytic subunit. (933 aa)
Cdkn1cCyclin-dependent kinase inhibitor 1C. (127 aa)
CDK3Cyclin dependent kinase 3. (297 aa)
Psmd926S proteasome non-ATPase regulatory subunit 9. (223 aa)
Esco1N-acetyltransferase ESCO1. (333 aa)
UbcPolyubiquitin-B. (235 aa)
Prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
H920_01229Cullin-1; Belongs to the cullin family. (265 aa)
POLE3DNA polymerase epsilon subunit 3. (147 aa)
H920_15675S-phase kinase-associated protein 1; Belongs to the SKP1 family. (135 aa)
CDC27Cell division cycle 27. (825 aa)
UBE2E1Ubiquitin-conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
RAD21Double-strand-break repair protein rad21 like protein. (631 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (421 aa)
PSMB9Proteasome subunit beta type-9. (219 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
Mcm8DNA replication licensing factor MCM8; Belongs to the MCM family. (833 aa)
RAD21L1RAD21 cohesin complex component like 1. (538 aa)
RFC4Replication factor C subunit 4. (333 aa)
ANAPC16Anaphase-promoting complex subunit 16. (110 aa)
TM7SF3Transmembrane 7 superfamily member 3. (487 aa)
ENSFDAP00000015944annotation not available (350 aa)
PSMB1Proteasome subunit beta. (240 aa)
STAG1Cohesin subunit SA-1. (1258 aa)
MCM6DNA helicase; Belongs to the MCM family. (786 aa)
LOC104868352Glycine N-acyltransferase. (295 aa)
PSMB5Proteasome subunit beta. (263 aa)
ANAPC15Protein HSPC020 like protein. (133 aa)
H920_20354S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
CCNA2Cyclin A2. (400 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5. (504 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (162 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
PSMB10Proteasome subunit beta. (273 aa)
CDK7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
PSMA6Proteasome subunit alpha type. (247 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
ANAPC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (808 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14. (310 aa)
PTK6Protein-tyrosine kinase 6. (451 aa)
ANAPC10Anaphase promoting complex subunit 10. (185 aa)
Pold4DNA polymerase delta subunit 4. (107 aa)
UBE2SUbiquitin-conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (212 aa)
H920_07431S-phase kinase-associated protein 1; Belongs to the SKP1 family. (136 aa)
PSMA4Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (210 aa)
PSMC526S protease regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
Fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
PDS5ASister chromatid cohesion protein PDS5 like protein A. (1337 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
H920_05040Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (97 aa)
RFC3Replication factor C subunit 3. (356 aa)
PSMB7Proteasome subunit beta type-7. (277 aa)
RPA3Replication protein A 14 kDa subunit. (122 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
RFC2Replication factor C subunit 2. (316 aa)
AKT3Non-specific serine/threonine protein kinase. (480 aa)
CDCA5Sororin. (236 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (331 aa)
POLA1DNA polymerase. (1462 aa)
WAPLWings apart-like protein like protein. (1194 aa)
Fam89bFamily with sequence similarity 89 member B. (93 aa)
ENSFDAP00000010230annotation not available (709 aa)
PSME2Proteasome activator complex subunit 2. (239 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
PSMC626S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (389 aa)
TCERG1LTranscription elongation regulator 1 like. (504 aa)
GINS3GINS complex subunit 3. (216 aa)
PSME4Proteasome activator subunit 4. (1804 aa)
CKS2CDC28 protein kinase regulatory subunit 2. (79 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa)
Cables1CDK5 and ABL1 enzyme substrate 1. (305 aa)
Tm4sf19Transmembrane 4 L6 family member 19. (181 aa)
RCBTB1RCC1 and BTB domain-containing protein 1. (531 aa)
Anapc11Anaphase-promoting complex subunit 11. (84 aa)
ANAPC7Anaphase-promoting complex subunit 7. (592 aa)
KIAA2012Uncharacterized protein. (1178 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMD2Proteasome 26S subunit, non-ATPase 2. (908 aa)
SMC3Structural maintenance of chromosomes protein 3. (1162 aa)
SKP2S-phase kinase-associated protein 2. (424 aa)
ANAPC1Anaphase-promoting complex subunit 1. (1944 aa)
PSMB3Proteasome subunit beta. (205 aa)
RFC1Replication factor C subunit 1. (1141 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
CDT1DNA replication factor Cdt1. (542 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (405 aa)
CDC26Transmembrane protein 71. (84 aa)
PSME3Proteasome activator complex subunit 3. (265 aa)
ATAD5ATPase family AAA domain-containing protein 5. (1822 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa)
ESCO2N-acetyltransferase ESCO2. (605 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (828 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4. (379 aa)
ANAPC5Anaphase-promoting complex subunit 5. (755 aa)
GMNNGeminin. (208 aa)
PSMF1Proteasome inhibitor PI31 subunit. (271 aa)
MCM5DNA helicase; Belongs to the MCM family. (678 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10. (226 aa)
CREBZFCREB/ATF bZIP transcription factor. (307 aa)
CDC16Cell division cycle protein 16 like protein. (626 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (324 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (827 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
FZR1Fizzy-related protein like protein. (493 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (506 aa)
ENSFDAP00000002920annotation not available (87 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa)
STAG2Cohesin subunit SA-2. (1268 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (165 aa)
DNA2DNA2-like helicase. (1059 aa)
GINS1DNA replication complex GINS protein PSF1. (196 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (391 aa)
PSMB6Proteasome subunit beta. (239 aa)
ORC3Origin recognition complex subunit 3. (720 aa)
PSMC326S protease regulatory subunit 6A. (440 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8. (350 aa)
CDC23Cell division cycle protein 23 like protein. (597 aa)
RFC5Replication factor C subunit 5. (338 aa)
Mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MCM3DNA helicase; Belongs to the MCM family. (817 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
CDC25BM-phase inducer phosphatase 2. (558 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PSMA5Proteasome 20S subunit alpha 5. (241 aa)
RB1Retinoblastoma-associated protein. (882 aa)
MNAT1CDK-activating kinase assembly factor MAT1. (309 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (405 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1. (953 aa)
RPA2Replication protein A 32 kDa subunit. (270 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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