STRINGSTRING
RPA3 RPA3 LOC104861528 LOC104861528 RFC2 RFC2 Ywhaz Ywhaz YWHAQ YWHAQ LOC104861514 LOC104861514 RAD17 RAD17 UBE2V2 UBE2V2 MEIOB MEIOB RAD9A RAD9A RAD1 RAD1 RPA1 RPA1 ENSFDAP00000021366 ENSFDAP00000021366 ENSFDAP00000012092 ENSFDAP00000012092 H2AX H2AX H920_14855 H920_14855 ATM ATM LOC104871423 LOC104871423 BABAM2 BABAM2 LOC104872243 LOC104872243 H920_04706 H920_04706 TP53BP1 TP53BP1 LOC104870598 LOC104870598 H2BC21 H2BC21 LOC104855197 LOC104855197 MRE11 MRE11 WEE1 WEE1 H920_00078 H920_00078 ENSFDAP00000020651 ENSFDAP00000020651 LOC104861520 LOC104861520 HERC2 HERC2 WRN WRN LOC104861348 LOC104861348 RNF168 RNF168 WEE2 WEE2 SFN SFN ATR ATR LOC104861510 LOC104861510 ENSFDAP00000011665 ENSFDAP00000011665 LOC104861527 LOC104861527 TP53 TP53 LOC104861523 LOC104861523 LOC104861518 LOC104861518 RFC3 RFC3 BRCA1 BRCA1 Brcc3 Brcc3 Babam1 Babam1 ABRAXAS1 ABRAXAS1 BLM BLM H920_04859 H920_04859 YWHAB YWHAB DNA2 DNA2 YWHAG YWHAG ENSFDAP00000002085 ENSFDAP00000002085 ENSFDAP00000001970 ENSFDAP00000001970 NSD2 NSD2 TOPBP1 TOPBP1 TDRD3 TDRD3 BRIP1 BRIP1 RFC5 RFC5 PIAS4 PIAS4 H2BU1 H2BU1 LOC104856844 LOC104856844 SLF1 SLF1 LOC104853831 LOC104853831 RMI1 RMI1 LOC104861347 LOC104861347 CDK1 CDK1 LOC104861338 LOC104861338 H920_06884 H920_06884 YWHAH YWHAH Rad50 Rad50 CHEK1 CHEK1 HUS1 HUS1 RPA2 RPA2 RNF8 RNF8 LOC104861529 LOC104861529 LOC104861522 LOC104861522 YWHAE YWHAE RNF169 RNF169 H920_07462 H920_07462 RAD9B RAD9B RBBP8 RBBP8 TOP3A TOP3A LOC104861515 LOC104861515 ANKRD31 ANKRD31 ATRIP ATRIP NBN NBN ENSFDAP00000006648 ENSFDAP00000006648 RMI2 RMI2 RHNO1 RHNO1 RECQL4 RECQL4 LOC104870596 LOC104870596 KAT5 KAT5 EXD2 EXD2 LOC104870593 LOC104870593 BARD1 BARD1 ENSFDAP00000017776 ENSFDAP00000017776 CHEK2 CHEK2 ENSFDAP00000016636 ENSFDAP00000016636 H2BC12 H2BC12 RFC4 RFC4 LOC104870592 LOC104870592 H920_04415 H920_04415
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA3Replication protein A 14 kDa subunit. (122 aa)
LOC104861528Histone H2B; Belongs to the histone H2B family. (126 aa)
RFC2Replication factor C subunit 2. (316 aa)
Ywhaz14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (245 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (304 aa)
LOC104861514Histone H4. (103 aa)
RAD17Cell cycle checkpoint protein RAD17. (714 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
MEIOBCDC24_OB3 domain-containing protein. (471 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (411 aa)
RAD1Cell cycle checkpoint protein RAD1. (279 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (615 aa)
ENSFDAP00000021366annotation not available (103 aa)
ENSFDAP00000012092annotation not available (103 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
H920_1485514-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (262 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa)
LOC104871423Histone H2B subacrosomal variant; Belongs to the histone H2B family. (122 aa)
BABAM2BRISC and BRCA1 A complex member 2. (409 aa)
LOC104872243Histone H4. (103 aa)
H920_04706Histone H2B type 1; Belongs to the histone H2B family. (143 aa)
TP53BP1Tumor suppressor p53-binding protein 1. (1958 aa)
LOC104870598Histone H2B type 1-K-like. (126 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (137 aa)
LOC10485519714-3-3 protein eta; Belongs to the 14-3-3 family. (246 aa)
MRE11MRE11 homolog, double strand break repair nuclease. (708 aa)
WEE1Zinc finger protein 143. (470 aa)
H920_00078Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (159 aa)
ENSFDAP00000020651annotation not available (191 aa)
LOC104861520Histone H2B; Belongs to the histone H2B family. (125 aa)
HERC2E3 ubiquitin-protein ligase HERC2. (4835 aa)
WRNWerner syndrome ATP-dependent helicase. (1439 aa)
LOC104861348Histone H4. (103 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (559 aa)
WEE2Wee1-like protein kinase 2. (511 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa)
LOC104861510Histone H4. (103 aa)
ENSFDAP00000011665annotation not available (103 aa)
LOC104861527Histone H2B; Belongs to the histone H2B family. (126 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
LOC104861523Histone H2B type 1. (126 aa)
LOC104861518Histone H2B; Belongs to the histone H2B family. (126 aa)
RFC3Replication factor C subunit 3. (356 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1737 aa)
Brcc3Lys-63-specific deubiquitinase BRCC36. (288 aa)
Babam1BRISC and BRCA1 A complex member 1. (293 aa)
ABRAXAS1BRCA1-A complex subunit Abraxas. (359 aa)
BLMBloom syndrome protein. (1348 aa)
H920_04859Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (246 aa)
DNA2DNA2-like helicase. (1059 aa)
YWHAG14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa)
ENSFDAP00000002085annotation not available (112 aa)
ENSFDAP00000001970annotation not available (234 aa)
NSD2Putative histone-lysine N-methyltransferase NSD2. (1366 aa)
TOPBP1DNA topoisomerase 2-binding protein 1. (1526 aa)
TDRD3Tudor domain-containing protein 3. (731 aa)
BRIP1Fanconi anemia group J protein. (1161 aa)
RFC5Replication factor C subunit 5. (338 aa)
PIAS4Protein inhibitor of activated STAT 4. (386 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC104856844Histone H2B; Belongs to the histone H2B family. (126 aa)
SLF1Ankyrin repeat domain-containing protein 32. (1057 aa)
LOC104853831Histone H2B; Belongs to the histone H2B family. (126 aa)
RMI1RecQ-mediated genome instability protein 1. (607 aa)
LOC104861347Histone H2B; Belongs to the histone H2B family. (126 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
LOC104861338Histone H4. (103 aa)
H920_0688414-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (245 aa)
YWHAH14-3-3 protein eta; Belongs to the 14-3-3 family. (217 aa)
Rad50DNA repair protein RAD50. (1312 aa)
CHEK1Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
RPA2Replication protein A 32 kDa subunit. (270 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (449 aa)
LOC104861529Histone H4. (103 aa)
LOC104861522Histone H2B; Belongs to the histone H2B family. (126 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
RNF169RING finger protein 169. (609 aa)
H920_07462Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (404 aa)
RBBP8RB binding protein 8, endonuclease. (901 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (991 aa)
LOC104861515Histone H2B; Belongs to the histone H2B family. (126 aa)
ANKRD31Ankyrin repeat domain-containing protein 31. (1857 aa)
ATRIPATR-interacting protein. (720 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (747 aa)
ENSFDAP00000006648annotation not available (129 aa)
RMI2RecQ mediated genome instability 2. (89 aa)
RHNO1Uncharacterized protein. (235 aa)
RECQL4ATP-dependent DNA helicase Q4. (1197 aa)
LOC104870596Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
EXD2Exonuclease 3'-5' domain-containing protein 2. (617 aa)
LOC104870593Histone H2B type 1-N. (126 aa)
BARD1BRCA1-associated RING domain protein 1. (672 aa)
ENSFDAP00000017776annotation not available (72 aa)
CHEK2Serine/threonine-protein kinase Chk2. (549 aa)
ENSFDAP00000016636annotation not available (103 aa)
H2BC12H2B clustered histone 12. (126 aa)
RFC4Replication factor C subunit 4. (333 aa)
LOC104870592Histone H2B; Belongs to the histone H2B family. (126 aa)
H920_04415BRCA1-A complex subunit RAP80. (415 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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