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| | H920_14855 | 14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (262 aa) |
| | PSMA4 | Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (210 aa) |
| | PSMC5 | 26S protease regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa) |
| | PSMA8 | Proteasome subunit alpha type. (250 aa) |
| | H2AX | Histone H2A; Belongs to the histone H2A family. (143 aa) |
| | ENSFDAP00000012092 | annotation not available (103 aa) |
| | SFN | 14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa) |
| | ATR | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa) |
| | LOC104861510 | Histone H4. (103 aa) |
| | CLSPN | Claspin. (1338 aa) |
| | ENSFDAP00000011665 | annotation not available (103 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | LOC104861527 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa) |
| | LOC104861523 | Histone H2B type 1. (126 aa) |
| | LOC104861518 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | PSMB7 | Proteasome subunit beta type-7. (277 aa) |
| | RPA3 | Replication protein A 14 kDa subunit. (122 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (903 aa) |
| | LOC104861528 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RFC2 | Replication factor C subunit 2. (316 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (449 aa) |
| | LOC104861529 | Histone H4. (103 aa) |
| | LOC104861522 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | WDR41 | WD repeat-containing protein 41. (435 aa) |
| | PSMD3 | 26S proteasome non-ATPase regulatory subunit 3. (331 aa) |
| | YWHAE | 14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | RNF169 | RING finger protein 169. (609 aa) |
| | ENSFDAP00000010230 | annotation not available (709 aa) |
| | H920_07462 | Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (142 aa) |
| | PSME2 | Proteasome activator complex subunit 2. (239 aa) |
| | ORC5 | Origin recognition complex subunit 5. (435 aa) |
| | PSMC6 | 26S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (389 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (404 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (901 aa) |
| | CDC7 | Cell division cycle 7-related protein kinase. (571 aa) |
| | PSME4 | Proteasome activator subunit 4. (1804 aa) |
| | Tm4sf19 | Transmembrane 4 L6 family member 19. (181 aa) |
| | PIEZO2 | Protein PIEZO2. (2786 aa) |
| | RCBTB1 | RCC1 and BTB domain-containing protein 1. (531 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (991 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | PSMD2 | Proteasome 26S subunit, non-ATPase 2. (908 aa) |
| | LOC104861515 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | DBF4 | Protein DBF4 like protein A. (636 aa) |
| | PSMB3 | Proteasome subunit beta. (205 aa) |
| | MCM10 | Protein MCM10 like protein. (874 aa) |
| | ANKRD31 | Ankyrin repeat domain-containing protein 31. (1857 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | H920_16529 | G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (277 aa) |
| | ATRIP | ATR-interacting protein. (720 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (747 aa) |
| | ENSFDAP00000006648 | annotation not available (129 aa) |
| | RMI2 | RecQ mediated genome instability 2. (89 aa) |
| | CDC25A | M-phase inducer phosphatase 1. (486 aa) |
| | PSME3 | Proteasome activator complex subunit 3. (265 aa) |
| | PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (263 aa) |
| | RHNO1 | Uncharacterized protein. (235 aa) |
| | RECQL4 | ATP-dependent DNA helicase Q4. (1197 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (828 aa) |
| | PSMD4 | 26S proteasome non-ATPase regulatory subunit 4. (379 aa) |
| | LOC104870596 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | PSMF1 | Proteasome inhibitor PI31 subunit. (271 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (678 aa) |
| | PSMD10 | 26S proteasome non-ATPase regulatory subunit 10. (226 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1737 aa) |
| | PKMYT1 | Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase. (490 aa) |
| | Brcc3 | Lys-63-specific deubiquitinase BRCC36. (288 aa) |
| | Babam1 | BRISC and BRCA1 A complex member 1. (293 aa) |
| | PSMD13 | 26S proteasome non-ATPase regulatory subunit 13. (376 aa) |
| | PSMD7 | 26S proteasome non-ATPase regulatory subunit 7. (324 aa) |
| | CDK2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa) |
| | ABRAXAS1 | BRCA1-A complex subunit Abraxas. (359 aa) |
| | BLM | Bloom syndrome protein. (1348 aa) |
| | H920_04859 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa) |
| | ENSFDAP00000002920 | annotation not available (87 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (558 aa) |
| | YWHAB | 14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (246 aa) |
| | DNA2 | DNA2-like helicase. (1059 aa) |
| | YWHAG | 14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa) |
| | ENSFDAP00000002085 | annotation not available (112 aa) |
| | PSMD11 | 26S proteasome non-ATPase regulatory subunit 11. (391 aa) |
| | ENSFDAP00000001970 | annotation not available (234 aa) |
| | NSD2 | Putative histone-lysine N-methyltransferase NSD2. (1366 aa) |
| | TOPBP1 | DNA topoisomerase 2-binding protein 1. (1526 aa) |
| | PSMB6 | Proteasome subunit beta. (239 aa) |
| | ORC3 | Origin recognition complex subunit 3. (720 aa) |
| | TDRD3 | Tudor domain-containing protein 3. (731 aa) |
| | BRIP1 | Fanconi anemia group J protein. (1161 aa) |
| | PSMC3 | 26S protease regulatory subunit 6A. (440 aa) |
| | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8. (350 aa) |
| | RFC5 | Replication factor C subunit 5. (338 aa) |
| | Mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (386 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (817 aa) |
| | RMI1 | RecQ-mediated genome instability protein 1. (607 aa) |
| | Rad50 | DNA repair protein RAD50. (1312 aa) |
| | CHEK1 | Serine/threonine-protein kinase Chk1; Belongs to the protein kinase superfamily. (476 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | H920_19240 | M-phase inducer phosphatase 3. (341 aa) |
| | PSMA5 | Proteasome 20S subunit alpha 5. (241 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1. (953 aa) |
| | RPA2 | Replication protein A 32 kDa subunit. (270 aa) |
| | YWHAQ | 14-3-3 protein theta; Belongs to the 14-3-3 family. (304 aa) |
| | PSMC2 | 26S protease regulatory subunit 7; Belongs to the AAA ATPase family. (464 aa) |
| | PSMC4 | 26S protease regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa) |
| | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12. (456 aa) |
| | PSMA3 | Proteasome subunit alpha type. (255 aa) |
| | ORC2 | Origin recognition complex subunit 2. (599 aa) |
| | UBA52 | KxDL motif containing 1. (232 aa) |
| | PSMA7 | Proteasome endopeptidase complex. (216 aa) |
| | LOC104861514 | Histone H4. (103 aa) |
| | RAD17 | Cell cycle checkpoint protein RAD17. (714 aa) |
| | UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2. (145 aa) |
| | MEIOB | CDC24_OB3 domain-containing protein. (471 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (411 aa) |
| | RAD1 | Cell cycle checkpoint protein RAD1. (279 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (615 aa) |
| | ENSFDAP00000021366 | annotation not available (103 aa) |
| | MRE11 | MRE11 homolog, double strand break repair nuclease. (708 aa) |
| | WEE1 | Zinc finger protein 143. (470 aa) |
| | CDC45 | Cell division control protein 45 like protein. (566 aa) |
| | H920_00078 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (159 aa) |
| | PSMA1 | Proteasome subunit alpha type-1. (264 aa) |
| | ENSFDAP00000020651 | annotation not available (191 aa) |
| | LOC104861520 | Histone H2B; Belongs to the histone H2B family. (125 aa) |
| | HERC2 | E3 ubiquitin-protein ligase HERC2. (4835 aa) |
| | CCNB2 | Cyclin B2. (397 aa) |
| | PSMC1 | 26S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa) |
| | WRN | Werner syndrome ATP-dependent helicase. (1439 aa) |
| | LOC104861348 | Histone H4. (103 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (559 aa) |
| | RCBTB2 | RCC1 and BTB domain-containing protein 2. (551 aa) |
| | PSME1 | Proteasome activator complex subunit 1. (249 aa) |
| | WEE2 | Wee1-like protein kinase 2. (511 aa) |
| | MCM9 | DNA replication licensing factor MCM9; Belongs to the MCM family. (1106 aa) |
| | PSMD6 | 26S proteasome non-ATPase regulatory subunit 6. (340 aa) |
| | H920_04415 | BRCA1-A complex subunit RAP80. (415 aa) |
| | Ywhaz | 14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (245 aa) |
| | CDK3 | Cyclin dependent kinase 3. (297 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa) |
| | Psmd9 | 26S proteasome non-ATPase regulatory subunit 9. (223 aa) |
| | EXD2 | Exonuclease 3'-5' domain-containing protein 2. (617 aa) |
| | Ubc | Polyubiquitin-B. (235 aa) |
| | LOC104870593 | Histone H2B type 1-N. (126 aa) |
| | BARD1 | BRCA1-associated RING domain protein 1. (672 aa) |
| | ENSFDAP00000017776 | annotation not available (72 aa) |
| | CCNB1 | G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (422 aa) |
| | CHEK2 | Serine/threonine-protein kinase Chk2. (549 aa) |
| | PSMB9 | Proteasome subunit beta type-9. (219 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | ENSFDAP00000016636 | annotation not available (103 aa) |
| | Mcm8 | DNA replication licensing factor MCM8; Belongs to the MCM family. (833 aa) |
| | H2BC12 | H2B clustered histone 12. (126 aa) |
| | RFC4 | Replication factor C subunit 4. (333 aa) |
| | LOC104870592 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC104856844 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | SLF1 | Ankyrin repeat domain-containing protein 32. (1057 aa) |
| | LOC104853831 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC104861347 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | PSMB1 | Proteasome subunit beta. (240 aa) |
| | CDK1 | Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (786 aa) |
| | PSMB5 | Proteasome subunit beta. (263 aa) |
| | LOC104861338 | Histone H4. (103 aa) |
| | PSMD5 | 26S proteasome non-ATPase regulatory subunit 5. (504 aa) |
| | H920_06884 | 14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (245 aa) |
| | PSMB10 | Proteasome subunit beta. (273 aa) |
| | YWHAH | 14-3-3 protein eta; Belongs to the 14-3-3 family. (217 aa) |
| | GTSE1 | G2 and S-phase expressed 1. (751 aa) |
| | LOC104855197 | 14-3-3 protein eta; Belongs to the 14-3-3 family. (246 aa) |
| | Ccnb3 | G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (1417 aa) |
| | H2BC21 | Histone H2B; Belongs to the histone H2B family. (137 aa) |
| | LOC104870598 | Histone H2B type 1-K-like. (126 aa) |
| | TP53BP1 | Tumor suppressor p53-binding protein 1. (1958 aa) |
| | PIEZO1 | Protein PIEZO1. (2427 aa) |
| | PSMA6 | Proteasome subunit alpha type. (247 aa) |
| | H920_04706 | Histone H2B type 1; Belongs to the histone H2B family. (143 aa) |
| | RPS27A | Ubiquitin-40S ribosomal protein S27a. (156 aa) |
| | LOC104872243 | Histone H4. (103 aa) |
| | PSMA2 | Proteasome subunit alpha type. (234 aa) |
| | PSMD14 | 26S proteasome non-ATPase regulatory subunit 14. (310 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (409 aa) |
| | LOC104871423 | Histone H2B subacrosomal variant; Belongs to the histone H2B family. (122 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa) |
