STRINGSTRING
GAK GAK HGS HGS SYT11 SYT11 TFRC TFRC COPS7A COPS7A SYT9 SYT9 COPS7B COPS7B LOC104863160 LOC104863160 GRK3 GRK3 NETO2 NETO2 COPS6 COPS6 PACSIN2 PACSIN2 SCARB2 SCARB2 AP2A1 AP2A1 CLHC1 CLHC1 FNBP1L FNBP1L EPN2 EPN2 SYNJ2 SYNJ2 LOC104862948 LOC104862948 DNM3 DNM3 ARRB2 ARRB2 H920_05210 H920_05210 LMBRD2 LMBRD2 GAPVD1 GAPVD1 CHRM2 CHRM2 GPR52 GPR52 EREG EREG H920_12193 H920_12193 ACTR2 ACTR2 ENSFDAP00000012870 ENSFDAP00000012870 H920_07302 H920_07302 TOR1A TOR1A Actb Actb ARF6 ARF6 SLC2A8 SLC2A8 LOC104860973 LOC104860973 H920_14239 H920_14239 ENSFDAP00000012053 ENSFDAP00000012053 SNX9 SNX9 Vamp2 Vamp2 LOC104857908 LOC104857908 FMN1 FMN1 H920_10388 H920_10388 CLTB CLTB Sh3kbp1 Sh3kbp1 CLTC CLTC NETO1 NETO1 HBEGF HBEGF SH3GL3 SH3GL3 FNBP1 FNBP1 AREG AREG LDLRAP1 LDLRAP1 AP2S1 AP2S1 TRIP10 TRIP10 ZFYVE19 ZFYVE19 DNM2 DNM2 AAK1 AAK1 EGF EGF COPS8 COPS8 SYT4 SYT4 NECAP1 NECAP1 REPS1 REPS1 UBQLN3 UBQLN3 Tgoln2 Tgoln2 UBL7 UBL7 PICALM PICALM ARPC5L ARPC5L STAM STAM AGFG2 AGFG2 ENSFDAP00000001872 ENSFDAP00000001872 CTTN CTTN Epn1 Epn1 KIAA0319L KIAA0319L VAMP7 VAMP7 FCHO2 FCHO2 VAMP8 VAMP8 HIP1 HIP1 CD3D CD3D AVPR2 AVPR2 ENSFDAP00000002920 ENSFDAP00000002920 KIAA0319 KIAA0319 FCHO1 FCHO1 BTC BTC Sh3d21 Sh3d21 ARFGAP1 ARFGAP1 CBL CBL CLPB CLPB PPP1R42 PPP1R42 ARPC1A ARPC1A Gas7 Gas7 EGFR EGFR TOR1B TOR1B H920_16947 H920_16947 DNAJC6 DNAJC6 SH3GL2 SH3GL2 SYT1 SYT1 GRB2 GRB2 H920_08701 H920_08701 APOB APOB ZFYVE1 ZFYVE1 COPS5 COPS5 HIP1R HIP1R Snx18 Snx18 SYT2 SYT2 SH3GL1 SH3GL1 SYNJ1 SYNJ1 TF TF ACTR3B ACTR3B VAMP5 VAMP5 AGTR1 AGTR1 CD3G CD3G LOC104870588 LOC104870588 LRP2 LRP2 ENTHD1 ENTHD1 PIK3C2A PIK3C2A WASL WASL EPS15L1 EPS15L1 MCTP1 MCTP1 DVL2 DVL2 M6PR M6PR UBA52 UBA52 ACTG1 ACTG1 ARPC3 ARPC3 ACTL8 ACTL8 COPS4 COPS4 PACSIN3 PACSIN3 ENSFDAP00000021627 ENSFDAP00000021627 CFTR CFTR AP2A2 AP2A2 OCRL OCRL STON2 STON2 CLTA CLTA BMP2K BMP2K EPGN EPGN BIN1 BIN1 RAB5B RAB5B GPS1 GPS1 ITSN2 ITSN2 CLTCL1 CLTCL1 UBQLN4 UBQLN4 Ston1 Ston1 H920_19720 H920_19720 REPS2 REPS2 ARPC2 ARPC2 Arpc5 Arpc5 SNAP91 SNAP91 ARRB1 ARRB1 GRK2 GRK2 SYT8 SYT8 AGFG1 AGFG1 AP2M1 AP2M1 Ubc Ubc COPS3 COPS3 ITSN1 ITSN1 EPS15 EPS15 NECAP2 NECAP2 DAB2 DAB2 H920_00021 H920_00021 ENSFDAP00000017585 ENSFDAP00000017585 WNT5A WNT5A VAMP3 VAMP3 Ubqln1 Ubqln1 H920_03666 H920_03666 Rab5a Rab5a TGFA TGFA ENSFDAP00000016887 ENSFDAP00000016887 IL7R IL7R TACR1 TACR1 ACTR3 ACTR3 STAM2 STAM2 SNX33 SNX33 AMPH AMPH LDLR LDLR SGIP1 SGIP1 COPS2 COPS2 PACSIN1 PACSIN1 IGF2R IGF2R LOC104856231 LOC104856231 ACTRT1 ACTRT1 H920_04111 H920_04111 ACTRT2 ACTRT2 MCTP2 MCTP2 DNM1 DNM1 PIP5K1C PIP5K1C Ap2b1 Ap2b1 RPS27A RPS27A FZD4 FZD4 VAMP4 VAMP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAKCyclin-G-associated kinase. (1288 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate. (778 aa)
SYT11Synaptotagmin-11. (431 aa)
TFRCTransferrin receptor protein 1. (765 aa)
COPS7ACOP9 signalosome complex subunit 7a. (277 aa)
SYT9Synaptotagmin-9. (442 aa)
COPS7BCOP9 signalosome complex subunit 7b. (264 aa)
LOC104863160Inhibitor of carbonic anhydrase; Belongs to the transferrin family. (700 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (646 aa)
NETO2Neuropilin and tolloid-like protein 2. (518 aa)
COPS6COP9 signalosome complex subunit 6. (347 aa)
PACSIN2Protein kinase C and casein kinase substrate in neurons 2. (470 aa)
SCARB2Lysosome membrane protein 2; Belongs to the CD36 family. (478 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (976 aa)
CLHC1TSNAXIP1_N domain-containing protein. (591 aa)
FNBP1LFormin-binding protein 1-like. (611 aa)
EPN2Epsin-2. (646 aa)
SYNJ2Synaptojanin-2. (1452 aa)
LOC104862948Phosphatidylinositol-binding clathrin assembly protein. (406 aa)
DNM3Dynamin-3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (859 aa)
ARRB2Beta-arrestin-2. (409 aa)
H920_05210Actin-41; Belongs to the actin family. (193 aa)
LMBRD2LMBR1 domain-containing protein 2. (694 aa)
GAPVD1GTPase-activating protein and VPS9 domain-containing protein 1. (1439 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
GPR52G protein-coupled receptor 52. (361 aa)
EREGProepiregulin. (163 aa)
H920_12193Actin, cytoplasmic type 8; Belongs to the actin family. (187 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
ENSFDAP00000012870annotation not available (208 aa)
H920_07302Ubiquilin-1. (487 aa)
TOR1AUncharacterized protein. (272 aa)
ActbActin, cytoplasmic 1. (375 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
SLC2A8Solute carrier family 2, facilitated glucose transporter member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (357 aa)
LOC104860973Low-density lipoprotein receptor-related protein 2. (2025 aa)
H920_14239SH3 domain-containing kinase-binding protein 1. (113 aa)
ENSFDAP00000012053annotation not available (81 aa)
SNX9Sorting nexin-9. (595 aa)
Vamp2Vesicle associated membrane protein 2. (146 aa)
LOC104857908Ubiquilin-1. (489 aa)
FMN1Formin-1. (1441 aa)
H920_10388NEDD8. (81 aa)
CLTBClathrin light chain B. (211 aa)
Sh3kbp1SH3 domain containing kinase binding protein 1. (709 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1679 aa)
NETO1Neuropilin and tolloid like 1. (530 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
SH3GL3Endophilin-A3. (312 aa)
FNBP1Formin-binding protein 1. (566 aa)
AREGAmphiregulin. (242 aa)
LDLRAP1Low density lipoprotein receptor adapter protein 1. (278 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (185 aa)
TRIP10Cdc42-interacting protein 4. (530 aa)
ZFYVE19Zinc finger FYVE domain-containing protein 19. (403 aa)
DNM2Dynamin-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (791 aa)
AAK1AP2-associated protein kinase 1. (965 aa)
EGFPro-epidermal growth factor. (1155 aa)
COPS8COP9 signalosome complex subunit 8. (209 aa)
SYT4Synaptotagmin-4. (425 aa)
NECAP1Adaptin ear-binding coat-associated protein 1. (269 aa)
REPS1RalBP1-associated Eps domain-containing protein 1. (744 aa)
UBQLN3Ubiquilin-3. (651 aa)
Tgoln2Trans-Golgi network integral membrane protein 2. (499 aa)
UBL7Ubiquitin-like protein 7. (380 aa)
PICALMPhosphatidylinositol-binding clathrin assembly protein. (660 aa)
ARPC5LActin related protein 2/3 complex subunit 5 like. (125 aa)
STAMSignal transducing adapter molecule 1. (542 aa)
AGFG2Arf-GAP domain and FG repeats-containing protein 2. (451 aa)
ENSFDAP00000001872annotation not available (356 aa)
CTTNSrc substrate cortactin. (548 aa)
Epn1Epsin 1. (54 aa)
KIAA0319LDyslexia-associated protein KIAA0319-like protein. (1077 aa)
VAMP7Vesicle-associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
FCHO2FCH domain only protein 2. (796 aa)
VAMP8Vesicle-associated membrane protein 8. (101 aa)
HIP1Huntingtin-interacting protein 1. (989 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (166 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (366 aa)
ENSFDAP00000002920annotation not available (87 aa)
KIAA0319Dyslexia-associated protein KIAA0319. (1123 aa)
FCHO1FCH and mu domain containing endocytic adaptor 1. (736 aa)
BTCProbetacellulin. (179 aa)
Sh3d21SH3 domain-containing protein 21. (669 aa)
ARFGAP1ADP ribosylation factor GTPase activating protein 1. (427 aa)
CBLE3 ubiquitin-protein ligase CBL. (851 aa)
CLPBCaseinolytic peptidase B protein like protein. (706 aa)
PPP1R42Protein phosphatase 1 regulatory subunit 42. (302 aa)
ARPC1AActin-related protein 2/3 complex subunit 1A. (370 aa)
Gas7Growth arrest-specific protein 7. (418 aa)
EGFRReceptor protein-tyrosine kinase. (1168 aa)
TOR1BTorsin-1B. (269 aa)
H920_16947Ras-related protein Rab-5A. (205 aa)
DNAJC6Putative tyrosine-protein phosphatase auxilin. (856 aa)
SH3GL2Endophilin-A1. (349 aa)
SYT1Synaptotagmin-1. (422 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
H920_08701Arrestin-C. (108 aa)
APOBApolipoprotein B-100. (4381 aa)
ZFYVE1Zinc finger FYVE domain-containing protein 1. (777 aa)
COPS5COP9 signalosome complex subunit 5. (334 aa)
HIP1RHuntingtin-interacting protein 1-related protein. (1012 aa)
Snx18Sorting nexin-18. (333 aa)
SYT2Synaptotagmin-2. (423 aa)
SH3GL1Endophilin-A2. (340 aa)
SYNJ1Synaptojanin-1. (1311 aa)
TFSerotransferrin. (695 aa)
ACTR3BActin-related protein 3B; Belongs to the actin family. (418 aa)
VAMP5Vesicle-associated membrane protein 5. (85 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
CD3GCD3g molecule. (182 aa)
LOC104870588NEDD8. (78 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4630 aa)
ENTHD1ENTH domain-containing protein 1. (597 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha; Belongs to the PI3/PI4-kinase family. (1685 aa)
WASLNeural Wiskott-Aldrich syndrome protein. (504 aa)
EPS15L1Epidermal growth factor receptor substrate 15-like 1. (795 aa)
MCTP1Multiple C2 and transmembrane domain-containing protein 1. (777 aa)
DVL2Segment polarity protein dishevelled like protein DVL-2. (736 aa)
M6PRCation-dependent mannose-6-phosphate receptor. (278 aa)
UBA52KxDL motif containing 1. (232 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (365 aa)
COPS4COP9 signalosome complex subunit 4. (406 aa)
PACSIN3Protein kinase C and casein kinase substrate in neurons protein 3. (423 aa)
ENSFDAP00000021627annotation not available (136 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1480 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (928 aa)
OCRLInositol polyphosphate 5-phosphatase OCRL-1. (888 aa)
STON2Stonin-2; Belongs to the Stoned B family. (894 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (242 aa)
BMP2KBMP-2-inducible protein kinase. (1074 aa)
EPGNEpithelial mitogen. (152 aa)
BIN1Bridging integrator 1. (556 aa)
RAB5BRas-related protein Rab-5B. (215 aa)
GPS1COP9 signalosome complex subunit 1. (490 aa)
ITSN2Intersectin-2. (1602 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1263 aa)
UBQLN4Ubiquilin-4. (558 aa)
Ston1Stonin-1; Belongs to the Stoned B family. (753 aa)
H920_19720Actin-related protein 2/3 complex subunit 1A. (254 aa)
REPS2RalBP1-associated Eps domain-containing protein 2. (602 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
Arpc5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
SNAP91Clathrin coat assembly protein AP180. (906 aa)
ARRB1Beta-arrestin-1. (418 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (686 aa)
SYT8Synaptotagmin-8. (387 aa)
AGFG1Arf-GAP domain and FG repeats-containing protein 1. (506 aa)
AP2M1AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family. (435 aa)
UbcPolyubiquitin-B. (235 aa)
COPS3COP9 signalosome complex subunit 3. (423 aa)
ITSN1Intersectin-1. (1716 aa)
EPS15Epidermal growth factor receptor substrate 15. (926 aa)
NECAP2NECAP endocytosis associated 2. (268 aa)
DAB2Disabled like protein 2. (769 aa)
H920_00021Actin-related protein 2/3 complex subunit 4. (89 aa)
ENSFDAP00000017585annotation not available (320 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
VAMP3Vesicle-associated membrane protein 3. (99 aa)
Ubqln1Ubiquilin-1. (529 aa)
H920_03666Epsin-3. (316 aa)
Rab5aRas-related protein Rab-5A. (215 aa)
TGFAProtransforming growth factor alpha. (157 aa)
ENSFDAP00000016887annotation not available (781 aa)
IL7RSperm flagellar protein 2. (457 aa)
TACR1Substance-P receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
ACTR3Actin-related protein 3; Belongs to the actin family. (418 aa)
STAM2Signal transducing adapter molecule 2. (524 aa)
SNX33Sorting nexin. (571 aa)
AMPHAmphiphysin. (647 aa)
LDLRLow-density lipoprotein receptor. (779 aa)
SGIP1SH3-containing GRB2-like protein 3-interacting protein 1. (828 aa)
COPS2COP9 signalosome complex subunit 2. (443 aa)
PACSIN1Protein kinase C and casein kinase substrate in neurons protein 1. (368 aa)
IGF2RCation-independent mannose-6-phosphate receptor. (2408 aa)
LOC104856231Actin; Belongs to the actin family. (945 aa)
ACTRT1Actin-related protein T1; Belongs to the actin family. (377 aa)
H920_04111Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (130 aa)
ACTRT2Actin-related protein T2; Belongs to the actin family. (377 aa)
MCTP2Multiple C2 and transmembrane domain-containing protein 2. (876 aa)
DNM1Dynamin-1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (738 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (649 aa)
Ap2b1AP complex subunit beta. (951 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (533 aa)
VAMP4Vesicle-associated membrane protein 4. (141 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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