STRINGSTRING
MSH2 MSH2 Mdm2 Mdm2 PIK3R1 PIK3R1 ENSFDAP00000020777 ENSFDAP00000020777 MAPK1 MAPK1 PIK3CA PIK3CA Pik3r2 Pik3r2 GSTM3 GSTM3 LOC104848128 LOC104848128 MAPK3 MAPK3 SLC31A1 SLC31A1 GSTT4 GSTT4 BAK1 BAK1 XIAP XIAP GSTM1 GSTM1 C7orf31 C7orf31 BCL2L1 BCL2L1 ENSFDAP00000016975 ENSFDAP00000016975 H920_10190 H920_10190 CASP8 CASP8 MAP3K5 MAP3K5 POLH POLH Bid Bid MGST1 MGST1 H920_01336 H920_01336 MLH1 MLH1 LOC104864952 LOC104864952 GSTM4 GSTM4 CASP9 CASP9 ENSFDAP00000013841 ENSFDAP00000013841 ERCC1 ERCC1 ATP7A ATP7A ERBB2 ERBB2 PIK3CD PIK3CD ATM ATM Faslg Faslg ENSFDAP00000011804 ENSFDAP00000011804 TP53 TP53 LOC104861153 LOC104861153 AKT3 AKT3 APAF1 APAF1 ATP7B ATP7B PPP1R14B PPP1R14B Casp3 Casp3 Pik3r3 Pik3r3 TOP2B TOP2B BIRC5 BIRC5 TOP2A TOP2A GSTO1 GSTO1 MSH6 MSH6 LOC104848127 LOC104848127 BAD BAD Fas Fas LOC104870271 LOC104870271 MGST3 MGST3 BRCA1 BRCA1 LOC104870640 LOC104870640 AKT1 AKT1 BIRC3 BIRC3 ENSFDAP00000003677 ENSFDAP00000003677 PDPK1 PDPK1 ABCC2 ABCC2 ENSFDAP00000002828 ENSFDAP00000002828 LOC104853071 LOC104853071 CDKN1A CDKN1A ENSFDAP00000002251 ENSFDAP00000002251 LOC104849516 LOC104849516 PIK3CB PIK3CB H920_08201 H920_08201 BAX BAX XPA XPA FADD FADD AKT2 AKT2 BIRC2 BIRC2 REV3L REV3L GSTO2 GSTO2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2. (504 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
ENSFDAP00000020777annotation not available (90 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Pik3r2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
GSTM3Glutathione S-transferase. (225 aa)
LOC104848128Glutathione S-transferase theta-1. (126 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
SLC31A1High affinity copper uptake protein 1. (191 aa)
GSTT4Glutathione S-transferase theta-4; Belongs to the GST superfamily. (241 aa)
BAK1Bcl-2 like proteinous antagonist/killer. (212 aa)
XIAPBaculoviral IAP repeat-containing protein 4. (497 aa)
GSTM1Glutathione S-transferase. (225 aa)
C7orf31Uncharacterized protein. (590 aa)
BCL2L1Bcl-2-like protein 1. (233 aa)
ENSFDAP00000016975annotation not available (180 aa)
H920_10190Glutathione S-transferase P. (168 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (462 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1300 aa)
POLHDNA polymerase eta. (709 aa)
BidBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (187 aa)
MGST1Microsomal glutathione S-transferase 1. (152 aa)
H920_01336DNA mismatch repair protein Msh3. (395 aa)
MLH1DNA mismatch repair protein Mlh1. (767 aa)
LOC104864952Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
GSTM4Glutathione S-transferase Mu 1; Belongs to the GST superfamily. (218 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (406 aa)
ENSFDAP00000013841annotation not available (257 aa)
ERCC1DNA excision repair protein ERCC-1. (298 aa)
ATP7ACopper-transporting ATPase 1. (1500 aa)
ERBB2Receptor protein-tyrosine kinase. (1212 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa)
FaslgTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (69 aa)
ENSFDAP00000011804annotation not available (202 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
LOC104861153Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
AKT3Non-specific serine/threonine protein kinase. (480 aa)
APAF1Apoptotic protease-activating factor 1. (1249 aa)
ATP7BCopper-transporting ATPase 2. (1463 aa)
PPP1R14BProtein phosphatase 1 regulatory subunit 14B. (122 aa)
Casp3Caspase-3; Belongs to the peptidase C14A family. (277 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1617 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (117 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1528 aa)
GSTO1Glutathione S-transferase omega-1; Belongs to the GST superfamily. (198 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1317 aa)
LOC104848127Glutathione S-transferase theta-3-like. (241 aa)
BADBcl2 antagonist of cell death. (162 aa)
FasTumor necrosis factor receptor superfamily member 6. (290 aa)
LOC104870271Glutathione S-transferase P 1. (210 aa)
MGST3Microsomal glutathione S-transferase 3. (153 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1737 aa)
LOC104870640Microsomal glutathione S-transferase 2. (147 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (644 aa)
ENSFDAP00000003677annotation not available (171 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (558 aa)
ABCC2Canalicular multispecific organic anion transporter 1. (1538 aa)
ENSFDAP00000002828annotation not available (86 aa)
LOC104853071Microsomal glutathione S-transferase 2. (147 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (165 aa)
ENSFDAP00000002251annotation not available (88 aa)
LOC104849516Glutathione S-transferase Mu 2. (181 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
H920_08201Glutathione S-transferase. (322 aa)
BAXApoptosis regulator BAX. (180 aa)
XPADNA repair protein complementing XP-A cells. (262 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (618 aa)
REV3LDNA polymerase zeta catalytic subunit. (3013 aa)
GSTO2Glutathione S-transferase omega-2; Belongs to the GST superfamily. (250 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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