(61 nodes) Base excision repair network (Fukomys damarensis)

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	H920_00581	Endonuclease 8-like 1. (145 aa)
	CACHD1	VWFA and cache domain-containing protein 1. (1211 aa)
	H920_11154	Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (177 aa)
	ADAT2	tRNA-specific adenosine deaminase 2. (174 aa)
	ENSFDAP00000015575	annotation not available (193 aa)
	Mecp2	methyl-CpG binding protein 2. (172 aa)
	CRISPLD2	Cysteine-rich secretory protein LCCL domain-containing 2. (597 aa)
	MPG	DNA-3-methyladenine glycosylase. (267 aa)
	Pold4	DNA polymerase delta subunit 4. (107 aa)
	MBD3L1	methyl-CpG binding domain protein 3 like 1. (194 aa)
	LOC104847770	Short transient receptor potential channel 2. (1234 aa)
	GTF3C1	General transcription factor 3C polypeptide 1. (2064 aa)
	Fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	Nthl1	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (302 aa)
	Ung	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (313 aa)
	MGMT	Methylated-DNA--protein-cysteine methyltransferase. (209 aa)
	PARP2	Poly [ADP-ribose] polymerase. (558 aa)
	GEN1	GEN1 Holliday junction 5' flap endonuclease. (869 aa)
	NEIL3	Endonuclease 8-like 3. (600 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (973 aa)
	PARP3	Poly [ADP-ribose] polymerase. (531 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2286 aa)
	CHRAC1	Chromatin accessibility complex protein 1. (128 aa)
	POLL	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (572 aa)
	R3HDML	Peptidase inhibitor R3HDML. (213 aa)
	PRKRIP1	PRKR-interacting protein 1. (189 aa)
	TDG	G/T mismatch-specific thymine DNA glycosylase. (404 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
	MBD2	Methyl-CpG-binding domain protein 2. (230 aa)
	MBD3	Methyl-CpG-binding domain protein 3. (282 aa)
	METTL4	Methyltransferase-like protein 4; Belongs to the MT-A70-like family. (471 aa)
	VWA5B1	Von Willebrand factor A domain-containing protein 5B1. (1274 aa)
	Ppil3	Peptidylprolyl isomerase like 3. (161 aa)
	LIG3	DNA ligase. (1016 aa)
	LOC104849308	Putative methyl-CpG-binding domain protein 3-like 5. (244 aa)
	NEIL2	Endonuclease 8-like 2. (316 aa)
	XRCC1	DNA repair protein XRCC1. (628 aa)
	CRISPLD1	Cysteine rich secretory protein LCCL domain containing 1. (500 aa)
	HMGB2	High mobility group box 2. (160 aa)
	Mutyh	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (530 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	ENSFDAP00000000117	annotation not available (223 aa)
	PARP4	Poly [ADP-ribose] polymerase. (1726 aa)
	OGG1	N-glycosylase/DNA lyase. (335 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
	GLIPR1L2	Uncharacterized protein. (338 aa)
	APEX2	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa)
	POLD2	DNA polymerase delta subunit 2. (469 aa)
	LIG1	DNA ligase. (916 aa)
	H920_16633	High mobility group protein B1. (166 aa)
	SMUG1	Single-strand selective monofunctional uracil DNA glycosylase. (272 aa)
	Pold3	DNA polymerase delta subunit 3. (465 aa)
	POLD1	DNA polymerase delta 1, catalytic subunit. (933 aa)
	H920_06373	High mobility group-T protein. (197 aa)
	POLE3	DNA polymerase epsilon subunit 3. (147 aa)
	Hmgb1	High mobility group protein B1. (215 aa)
	VWA5A	Von Willebrand factor A domain-containing protein 5A. (805 aa)
	VWA5B2	Von Willebrand factor A domain containing 5B2. (1019 aa)
	APEX1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
	NOLC1	Nucleolar and coiled-body phosphoprotein 1. (706 aa)
	Hmgb3	High mobility group protein B3. (198 aa)

Your Current Organism:

Fukomys damarensis

NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAT2	APEX1	ENSFDAP00000016171	ENSFDAP00000017576	tRNA-specific adenosine deaminase 2.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.632
ADAT2	APEX2	ENSFDAP00000016171	ENSFDAP00000020937	tRNA-specific adenosine deaminase 2.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.632
ADAT2	Fen1	ENSFDAP00000016171	ENSFDAP00000012012	tRNA-specific adenosine deaminase 2.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.411
ADAT2	H920_00581	ENSFDAP00000016171	ENSFDAP00000017400	tRNA-specific adenosine deaminase 2.	Endonuclease 8-like 1.	0.420
ADAT2	MPG	ENSFDAP00000016171	ENSFDAP00000014657	tRNA-specific adenosine deaminase 2.	DNA-3-methyladenine glycosylase.	0.463
ADAT2	NEIL2	ENSFDAP00000016171	ENSFDAP00000003780	tRNA-specific adenosine deaminase 2.	Endonuclease 8-like 2.	0.418
ADAT2	OGG1	ENSFDAP00000016171	ENSFDAP00000023277	tRNA-specific adenosine deaminase 2.	N-glycosylase/DNA lyase.	0.479
ADAT2	TDG	ENSFDAP00000016171	ENSFDAP00000007208	tRNA-specific adenosine deaminase 2.	G/T mismatch-specific thymine DNA glycosylase.	0.496
ADAT2	Ung	ENSFDAP00000016171	ENSFDAP00000011059	tRNA-specific adenosine deaminase 2.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.	0.651
APEX1	ADAT2	ENSFDAP00000017576	ENSFDAP00000016171	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	tRNA-specific adenosine deaminase 2.	0.632
APEX1	APEX2	ENSFDAP00000017576	ENSFDAP00000020937	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.913
APEX1	Fen1	ENSFDAP00000017576	ENSFDAP00000012012	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.995
APEX1	GEN1	ENSFDAP00000017576	ENSFDAP00000010467	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	GEN1 Holliday junction 5' flap endonuclease.	0.731
APEX1	H920_00581	ENSFDAP00000017576	ENSFDAP00000017400	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Endonuclease 8-like 1.	0.435
APEX1	H920_11154	ENSFDAP00000017576	ENSFDAP00000016353	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.	0.632
APEX1	LIG1	ENSFDAP00000017576	ENSFDAP00000020814	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA ligase.	0.958
APEX1	LIG3	ENSFDAP00000017576	ENSFDAP00000004129	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA ligase.	0.858
APEX1	LOC104849308	ENSFDAP00000017576	ENSFDAP00000004107	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Putative methyl-CpG-binding domain protein 3-like 5.	0.405
APEX1	MBD2	ENSFDAP00000017576	ENSFDAP00000006305	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Methyl-CpG-binding domain protein 2.	0.414
APEX1	MBD3	ENSFDAP00000017576	ENSFDAP00000004812	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Methyl-CpG-binding domain protein 3.	0.414