(40 nodes) Mismatch repair network (Fukomys damarensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	POLD2	DNA polymerase delta subunit 2. (469 aa)
	RPA2	Replication protein A 32 kDa subunit. (270 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	RFC5	Replication factor C subunit 5. (338 aa)
	MSH4	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (854 aa)
	ENSFDAP00000003677	annotation not available (171 aa)
	Ppil3	Peptidylprolyl isomerase like 3. (161 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1317 aa)
	ATAD5	ATPase family AAA domain-containing protein 5. (1822 aa)
	YJU2	Coiled-coil domain-containing protein 94. (316 aa)
	PRKRIP1	PRKR-interacting protein 1. (189 aa)
	RFC1	Replication factor C subunit 1. (1141 aa)
	REXO4	RNA exonuclease 4. (417 aa)
	Msh5	MutS protein like protein 5. (827 aa)
	SSBP1	Single stranded DNA binding protein 1. (149 aa)
	RFC2	Replication factor C subunit 2. (316 aa)
	RPA3	Replication protein A 14 kDa subunit. (122 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	Pold4	DNA polymerase delta subunit 4. (107 aa)
	MLH1	DNA mismatch repair protein Mlh1. (767 aa)
	H920_01336	DNA mismatch repair protein Msh3. (395 aa)
	Pms2	PMS1 homolog 2, mismatch repair system component. (461 aa)
	RFC4	Replication factor C subunit 4. (333 aa)
	PMS1	PMS1 protein like protein 1. (931 aa)
	FBH1	F-box only protein 18. (1042 aa)
	AEN	Apoptosis-enhancing nuclease. (320 aa)
	SASS6	SAS-6 centriolar assembly protein. (657 aa)
	POLD1	DNA polymerase delta 1, catalytic subunit. (933 aa)
	Pold3	DNA polymerase delta subunit 3. (465 aa)
	ISG20L2	Interferon-stimulated 20 kDa exonuclease-like 2. (384 aa)
	ENSFDAP00000020651	annotation not available (191 aa)
	LIG1	DNA ligase. (916 aa)
	MLH3	DNA mismatch repair protein Mlh3. (1446 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (615 aa)
	SHF	SH2 domain-containing adapter protein F. (321 aa)
	MEIOB	CDC24_OB3 domain-containing protein. (471 aa)
	STN1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (375 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
	ISG20	Interferon-stimulated gene 20 kDa protein. (181 aa)
	RAD17	Cell cycle checkpoint protein RAD17. (714 aa)

Your Current Organism:

Fukomys damarensis

NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEN	FBH1	ENSFDAP00000018559	ENSFDAP00000018439	Apoptosis-enhancing nuclease.	F-box only protein 18.	0.714
AEN	PCNA	ENSFDAP00000018559	ENSFDAP00000000579	Apoptosis-enhancing nuclease.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.858
AEN	RAD17	ENSFDAP00000018559	ENSFDAP00000021946	Apoptosis-enhancing nuclease.	Cell cycle checkpoint protein RAD17.	0.494
AEN	RFC2	ENSFDAP00000018559	ENSFDAP00000011100	Apoptosis-enhancing nuclease.	Replication factor C subunit 2.	0.494
AEN	RFC3	ENSFDAP00000018559	ENSFDAP00000011384	Apoptosis-enhancing nuclease.	Replication factor C subunit 3.	0.502
AEN	RFC4	ENSFDAP00000018559	ENSFDAP00000016432	Apoptosis-enhancing nuclease.	Replication factor C subunit 4.	0.494
AEN	RFC5	ENSFDAP00000018559	ENSFDAP00000001452	Apoptosis-enhancing nuclease.	Replication factor C subunit 5.	0.494
AEN	SSBP1	ENSFDAP00000018559	ENSFDAP00000009320	Apoptosis-enhancing nuclease.	Single stranded DNA binding protein 1.	0.458
ATAD5	ENSFDAP00000020651	ENSFDAP00000006258	ENSFDAP00000020651	ATPase family AAA domain-containing protein 5.	annotation not available	0.969
ATAD5	FBH1	ENSFDAP00000006258	ENSFDAP00000018439	ATPase family AAA domain-containing protein 5.	F-box only protein 18.	0.730
ATAD5	LIG1	ENSFDAP00000006258	ENSFDAP00000020814	ATPase family AAA domain-containing protein 5.	DNA ligase.	0.883
ATAD5	MEIOB	ENSFDAP00000006258	ENSFDAP00000021681	ATPase family AAA domain-containing protein 5.	CDC24_OB3 domain-containing protein.	0.843
ATAD5	MLH1	ENSFDAP00000006258	ENSFDAP00000014822	ATPase family AAA domain-containing protein 5.	DNA mismatch repair protein Mlh1.	0.447
ATAD5	MSH2	ENSFDAP00000006258	ENSFDAP00000021797	ATPase family AAA domain-containing protein 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.518
ATAD5	MSH6	ENSFDAP00000006258	ENSFDAP00000006137	ATPase family AAA domain-containing protein 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.578
ATAD5	PCNA	ENSFDAP00000006258	ENSFDAP00000000579	ATPase family AAA domain-containing protein 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.990
ATAD5	POLD1	ENSFDAP00000006258	ENSFDAP00000019600	ATPase family AAA domain-containing protein 5.	DNA polymerase delta 1, catalytic subunit.	0.873
ATAD5	POLD2	ENSFDAP00000006258	ENSFDAP00000022279	ATPase family AAA domain-containing protein 5.	DNA polymerase delta subunit 2.	0.748
ATAD5	Pold4	ENSFDAP00000006258	ENSFDAP00000013358	ATPase family AAA domain-containing protein 5.	DNA polymerase delta subunit 4.	0.518
ATAD5	RAD17	ENSFDAP00000006258	ENSFDAP00000021946	ATPase family AAA domain-containing protein 5.	Cell cycle checkpoint protein RAD17.	0.968