STRINGSTRING
HELB HELB TM6SF2 TM6SF2 H920_09081 H920_09081 ATM ATM BABAM2 BABAM2 Rad54b Rad54b Pold4 Pold4 EME1 EME1 RAD51B RAD51B ABRAXAS2 ABRAXAS2 BRCA2 BRCA2 N4BP2L1 N4BP2L1 C12orf66 C12orf66 DMC1 DMC1 SLF1 SLF1 LOC104862152 LOC104862152 XRCC3 XRCC3 Sem1 Sem1 ENSFDAP00000017292 ENSFDAP00000017292 BARD1 BARD1 SLC4A1AP SLC4A1AP SASS6 SASS6 MPHOSPH9 MPHOSPH9 POLD1 POLD1 Pold3 Pold3 H920_04415 H920_04415 Ddx52 Ddx52 SAP130 SAP130 RAD54L RAD54L CNP CNP RPA1 RPA1 SHF SHF MEIOB MEIOB STN1 STN1 TOP3B TOP3B LURAP1 LURAP1 POLD2 POLD2 SYCP3 SYCP3 XRCC2 XRCC2 SUGP2 SUGP2 RECQL5 RECQL5 RAD51D RAD51D ENSFDAP00000001970 ENSFDAP00000001970 TOPBP1 TOPBP1 BRIP1 BRIP1 PALB2 PALB2 H920_13560 H920_13560 Rad50 Rad50 MCFD2 MCFD2 RPA2 RPA2 UNC93B1 UNC93B1 BLM BLM ABRAXAS1 ABRAXAS1 PIF1 PIF1 Ppil3 Ppil3 Babam1 Babam1 Brcc3 Brcc3 BRCA1 BRCA1 MRE11 MRE11 SUGP1 SUGP1 RAD52 RAD52 RECQL4 RECQL4 RAD51 RAD51 NBN NBN YJU2 YJU2 PRKRIP1 PRKRIP1 ATRX ATRX RBPMS2 RBPMS2 RAD51C RAD51C N4BP2 N4BP2 TOP3A TOP3A MUS81 MUS81 SSBP1 SSBP1 RBBP8 RBBP8 HELQ HELQ FICD FICD RPA3 RPA3 PITHD1 PITHD1 UNC93A UNC93A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HELBDNA helicase B. (993 aa)
TM6SF2Transmembrane 6 superfamily member 2. (343 aa)
H920_09081Putative G-protein coupled receptor 44; Belongs to the G-protein coupled receptor 1 family. (206 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa)
BABAM2BRISC and BRCA1 A complex member 2. (409 aa)
Rad54bDNA repair and recombination protein RAD54B. (908 aa)
Pold4DNA polymerase delta subunit 4. (107 aa)
EME1Crossover junction endonuclease EME1. (554 aa)
RAD51BDNA repair protein RAD51 like protein 2. (258 aa)
ABRAXAS2BRISC complex subunit Abro1. (414 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3134 aa)
N4BP2L1NEDD4-binding protein 2-like 1. (195 aa)
C12orf66Uncharacterized protein. (445 aa)
DMC1DNA meiotic recombinase 1. (340 aa)
SLF1Ankyrin repeat domain-containing protein 32. (1057 aa)
LOC104862152NEDD4-binding protein 2-like 2. (1151 aa)
XRCC3DNA repair protein XRCC3. (338 aa)
Sem126S proteasome complex subunit DSS1. (70 aa)
ENSFDAP00000017292annotation not available (27 aa)
BARD1BRCA1-associated RING domain protein 1. (672 aa)
SLC4A1APKanadaptin. (533 aa)
SASS6SAS-6 centriolar assembly protein. (657 aa)
MPHOSPH9M-phase phosphoprotein 9. (1148 aa)
POLD1DNA polymerase delta 1, catalytic subunit. (933 aa)
Pold3DNA polymerase delta subunit 3. (465 aa)
H920_04415BRCA1-A complex subunit RAP80. (415 aa)
Ddx52Hepatocyte nuclear factor 1-beta. (597 aa)
SAP130Histone deacetylase complex subunit SAP130. (1056 aa)
RAD54LDNA repair and recombination protein RAD54-like. (747 aa)
CNP2',3'-cyclic nucleotide 3' phosphodiesterase. (420 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (615 aa)
SHFSH2 domain-containing adapter protein F. (321 aa)
MEIOBCDC24_OB3 domain-containing protein. (471 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (375 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
LURAP1Uncharacterized protein. (239 aa)
POLD2DNA polymerase delta subunit 2. (469 aa)
SYCP3Synaptonemal complex protein 3. (239 aa)
XRCC2Actin related protein 3B. (231 aa)
SUGP2SURP and G-patch domain-containing protein 2. (1087 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (967 aa)
RAD51DDNA repair protein RAD51 like protein 4. (329 aa)
ENSFDAP00000001970annotation not available (234 aa)
TOPBP1DNA topoisomerase 2-binding protein 1. (1526 aa)
BRIP1Fanconi anemia group J protein. (1161 aa)
PALB2Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (1185 aa)
H920_13560Protein Jade-3. (571 aa)
Rad50DNA repair protein RAD50. (1312 aa)
MCFD2Multiple coagulation factor deficiency protein 2 like protein. (146 aa)
RPA2Replication protein A 32 kDa subunit. (270 aa)
UNC93B1Protein unc-93 like protein B1. (550 aa)
BLMBloom syndrome protein. (1348 aa)
ABRAXAS1BRCA1-A complex subunit Abraxas. (359 aa)
PIF1PIF1 5'-to-3' DNA helicase. (521 aa)
Ppil3Peptidylprolyl isomerase like 3. (161 aa)
Babam1BRISC and BRCA1 A complex member 1. (293 aa)
Brcc3Lys-63-specific deubiquitinase BRCC36. (288 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1737 aa)
MRE11MRE11 homolog, double strand break repair nuclease. (708 aa)
SUGP1SURP and G-patch domain containing 1. (659 aa)
RAD52DNA repair protein RAD52 like protein. (294 aa)
RECQL4ATP-dependent DNA helicase Q4. (1197 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (747 aa)
YJU2Coiled-coil domain-containing protein 94. (316 aa)
PRKRIP1PRKR-interacting protein 1. (189 aa)
ATRXTranscriptional regulator ATRX. (2492 aa)
RBPMS2RNA-binding protein with multiple splicing 2. (179 aa)
RAD51CDNA repair protein RAD51 like protein 3. (367 aa)
N4BP2NEDD4-binding protein 2. (1772 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (991 aa)
MUS81Crossover junction endonuclease MUS81. (539 aa)
SSBP1Single stranded DNA binding protein 1. (149 aa)
RBBP8RB binding protein 8, endonuclease. (901 aa)
HELQHelicase POLQ-like. (987 aa)
FICDAdenosine monophosphate-protein transferase FICD. (458 aa)
RPA3Replication protein A 14 kDa subunit. (122 aa)
PITHD1PITH domain containing 1. (211 aa)
UNC93AProtein unc-93 like protein A. (457 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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