STRINGSTRING
Pik3r2 Pik3r2 PIK3CA PIK3CA MAPK1 MAPK1 DDIT3 DDIT3 MAPK10 MAPK10 IKBKG IKBKG CASP2 CASP2 PIK3R1 PIK3R1 LOC104873568 LOC104873568 RELA RELA MAP2K1 MAP2K1 Septin4 Septin4 LOC104855306 LOC104855306 AIFM1 AIFM1 BAD BAD SPTAN1 SPTAN1 TRADD TRADD Fas Fas ITPR1 ITPR1 CAPN11 CAPN11 LMNA LMNA FOS FOS Diablo Diablo CSDE1 CSDE1 CAPN1 CAPN1 ACTL8 ACTL8 ACTG1 ACTG1 CAPN9 CAPN9 SEPTIN4 SEPTIN4 BIRC2 BIRC2 GADD45G GADD45G TRAF1 TRAF1 AKT2 AKT2 NRAS NRAS ERN1 ERN1 PRF1 PRF1 MAPK8 MAPK8 TNF TNF LOC104874823 LOC104874823 LOC104864185 LOC104864185 AKT1 AKT1 BIRC3 BIRC3 EXOG EXOG PDPK1 PDPK1 MAP3K14 MAP3K14 Map2k2 Map2k2 HTRA4 HTRA4 CASP7 CASP7 CENPU CENPU ENSFDAP00000002828 ENSFDAP00000002828 RAF1 RAF1 IKBKB IKBKB CTSB CTSB ENSFDAP00000002352 ENSFDAP00000002352 ENSFDAP00000002251 ENSFDAP00000002251 PIK3CB PIK3CB ATF4 ATF4 H920_06972 H920_06972 BAX BAX TRAF2 TRAF2 BCL2A1 BCL2A1 Tnfrsf10b Tnfrsf10b PARP4 PARP4 FADD FADD IFITM10 IFITM10 XIAP XIAP LOC104864184 LOC104864184 LOC104861958 LOC104861958 ENSFDAP00000018414 ENSFDAP00000018414 LMNB2 LMNB2 BAK1 BAK1 BCL2L11 BCL2L11 CTSC CTSC PIDD1 PIDD1 PPP1R14B PPP1R14B SUCO SUCO Ctsd Ctsd DFFB DFFB EIF2AK3 EIF2AK3 LOC104861955 LOC104861955 ENSFDAP00000010317 ENSFDAP00000010317 RIPK1 RIPK1 CAPN12 CAPN12 PARP2 PARP2 SPTA1 SPTA1 LMNB1 LMNB1 CTSF CTSF CTSO CTSO MAPK9 MAPK9 ITPR3 ITPR3 APAF1 APAF1 AKT3 AKT3 CTSH CTSH LOC104861153 LOC104861153 CAPN2 CAPN2 H920_07665 H920_07665 ENSFDAP00000011603 ENSFDAP00000011603 TP53 TP53 TUBA4A TUBA4A HRAS HRAS Actb Actb H920_18855 H920_18855 Faslg Faslg ATM ATM PIK3CD PIK3CD H920_12193 H920_12193 KRAS KRAS CTSV CTSV CTSZ CTSZ ENSFDAP00000013841 ENSFDAP00000013841 CASP9 CASP9 CTSK CTSK EIF2S1 EIF2S1 CTSS CTSS HTRA1 HTRA1 LOC104864952 LOC104864952 GZMH GZMH ACTRT2 ACTRT2 LOC104859867 LOC104859867 LOC104875392 LOC104875392 ACTRT1 ACTRT1 LOC104856231 LOC104856231 Bid Bid MAP3K5 MAP3K5 NFKBIA NFKBIA LOC104864167 LOC104864167 TUBA8 TUBA8 Chuk Chuk CASP8 CASP8 BCL2L1 BCL2L1 Ern2 Ern2 C7orf31 C7orf31 ITPR2 ITPR2 PTPN13 PTPN13 NFKB1 NFKB1 PARP1 PARP1 DAB2IP DAB2IP Casp3 Casp3 PARP3 PARP3 JUN JUN NGF NGF MAPK3 MAPK3 CTSW CTSW HTRA2 HTRA2 CAPN3 CAPN3 RRAD RRAD CFLAR CFLAR Pik3r3 Pik3r3 H920_05210 H920_05210 NTRK1 NTRK1 LOC104859914 LOC104859914 REM1 REM1 CASP6 CASP6 BIRC5 BIRC5 HPS5 HPS5 TNFSF10 TNFSF10 DAXX DAXX GEM GEM NMRK2 NMRK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Pik3r2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
DDIT3DNA damage-inducible transcript 3 protein. (167 aa)
MAPK10Mitogen-activated protein kinase. (478 aa)
IKBKGNF-kappa-B essential modulator. (417 aa)
CASP2Caspase-2; Belongs to the peptidase C14A family. (452 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
LOC104873568Interferon-induced transmembrane protein 3. (135 aa)
RELATranscription factor p65. (545 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (388 aa)
Septin4Septin 4. (471 aa)
LOC104855306Cytokine receptor common subunit beta. (652 aa)
AIFM1Apoptosis-inducing factor 1, mitochondrial. (619 aa)
BADBcl2 antagonist of cell death. (162 aa)
SPTAN1Spectrin alpha chain, brain. (2498 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (310 aa)
FasTumor necrosis factor receptor superfamily member 6. (290 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2758 aa)
CAPN11Calpain-11; Belongs to the peptidase C2 family. (756 aa)
LMNAPrelamin-A/C; Belongs to the intermediate filament family. (453 aa)
FOSProto-oncogene c-Fos. (380 aa)
DiabloDiablo like protein, mitochondrial. (233 aa)
CSDE1Cold shock domain-containing protein E1. (798 aa)
CAPN1Calpain-1 catalytic subunit; Belongs to the peptidase C2 family. (714 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (365 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
CAPN9Calpain-9; Belongs to the peptidase C2 family. (690 aa)
SEPTIN4Uncharacterized protein. (500 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (618 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
TRAF1TNF receptor-associated factor. (415 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (956 aa)
PRF1Perforin-1. (554 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
LOC104874823Caspase-12; Belongs to the peptidase C14A family. (449 aa)
LOC104864185Granzyme-like protein 1; Belongs to the peptidase S1 family. (254 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (644 aa)
EXOGNuclease EXOG, mitochondrial. (368 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (558 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (945 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (370 aa)
HTRA4Putative serine protease HTRA4. (350 aa)
CASP7Caspase-7; Belongs to the peptidase C14A family. (314 aa)
CENPUCentromere protein U. (382 aa)
ENSFDAP00000002828annotation not available (86 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (340 aa)
ENSFDAP00000002352annotation not available (382 aa)
ENSFDAP00000002251annotation not available (88 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (352 aa)
H920_06972DNAation factor subunit alpha. (181 aa)
BAXApoptosis regulator BAX. (180 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
BCL2A15-formyltetrahydrofolate cyclo-ligase. (171 aa)
Tnfrsf10bTumor necrosis factor receptor superfamily member 10B. (417 aa)
PARP4Poly [ADP-ribose] polymerase. (1726 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
IFITM10Interferon-induced transmembrane protein 10. (130 aa)
XIAPBaculoviral IAP repeat-containing protein 4. (497 aa)
LOC104864184Granzyme B(G,H); Belongs to the peptidase S1 family. (235 aa)
LOC104861958Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
ENSFDAP00000018414annotation not available (666 aa)
LMNB2Lamin B2. (451 aa)
BAK1Bcl-2 like proteinous antagonist/killer. (212 aa)
BCL2L11BCL2 like 11. (195 aa)
CTSCDipeptidyl peptidase 1; Belongs to the peptidase C1 family. (469 aa)
PIDD1P53-induced protein with a death domain. (905 aa)
PPP1R14BProtein phosphatase 1 regulatory subunit 14B. (122 aa)
SUCOSUN domain-containing protein. (1254 aa)
CtsdCathepsin D; Belongs to the peptidase A1 family. (410 aa)
DFFBDNAation factor subunit beta. (310 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (1007 aa)
LOC104861955Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
ENSFDAP00000010317annotation not available (274 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (660 aa)
CAPN12Calpain 12. (657 aa)
PARP2Poly [ADP-ribose] polymerase. (558 aa)
SPTA1Spectrin alpha chain, erythrocyte. (2398 aa)
LMNB1Lamin-B1; Belongs to the intermediate filament family. (516 aa)
CTSFCathepsin F; Belongs to the peptidase C1 family. (438 aa)
CTSOCathepsin O. (297 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2524 aa)
APAF1Apoptotic protease-activating factor 1. (1249 aa)
AKT3Non-specific serine/threonine protein kinase. (480 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (335 aa)
LOC104861153Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
CAPN2Calpain-2 catalytic subunit; Belongs to the peptidase C2 family. (597 aa)
H920_07665Pro-cathepsin H. (139 aa)
ENSFDAP00000011603annotation not available (308 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
HRASHRas proto-oncogene, GTPase. (191 aa)
ActbActin, cytoplasmic 1. (375 aa)
H920_18855Tubulin alpha-1C chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (246 aa)
FaslgTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (69 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
H920_12193Actin, cytoplasmic type 8; Belongs to the actin family. (187 aa)
KRASGTPase HRas. (189 aa)
CTSVCathepsin L1; Belongs to the peptidase C1 family. (334 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (263 aa)
ENSFDAP00000013841annotation not available (257 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (406 aa)
CTSKCathepsin K. (328 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
CTSSGolgi phosphoprotein 3-like; Belongs to the peptidase C1 family. (331 aa)
HTRA1Serine protease HTRA1. (391 aa)
LOC104864952Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
GZMHGranzyme H; Belongs to the peptidase S1 family. (245 aa)
ACTRT2Actin-related protein T2; Belongs to the actin family. (377 aa)
LOC104859867Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
LOC104875392Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
ACTRT1Actin-related protein T1; Belongs to the actin family. (377 aa)
LOC104856231Actin; Belongs to the actin family. (945 aa)
BidBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (187 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1300 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
LOC104864167Granzyme B; Belongs to the peptidase S1 family. (247 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha. (744 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (462 aa)
BCL2L1Bcl-2-like protein 1. (233 aa)
Ern2Endoplasmic reticulum to nucleus signaling 2. (928 aa)
C7orf31Uncharacterized protein. (590 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
PTPN13Tyrosine-protein phosphatase non-receptor type 13. (2437 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (894 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (973 aa)
DAB2IPDisabled like protein 2-interacting protein. (1161 aa)
Casp3Caspase-3; Belongs to the peptidase C14A family. (277 aa)
PARP3Poly [ADP-ribose] polymerase. (531 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (254 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (305 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
CTSWCathepsin W; Belongs to the peptidase C1 family. (371 aa)
HTRA2Serine protease HTRA2, mitochondrial. (453 aa)
CAPN3Calpain-3; Belongs to the peptidase C2 family. (909 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (311 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (435 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
H920_05210Actin-41; Belongs to the actin family. (193 aa)
NTRK1Tyrosine-protein kinase receptor. (727 aa)
LOC104859914Tubulin alpha-3 chain-like. (297 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (274 aa)
CASP6Caspase-6; Belongs to the peptidase C14A family. (272 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (117 aa)
HPS5Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1123 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (289 aa)
DAXXDeath domain-associated protein 6. (684 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
NMRK2Nicotinamide riboside kinase 2. (193 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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