STRINGSTRING
ELK3 ELK3 TLN1 TLN1 PRKCA PRKCA PAK3 PAK3 COL6A6 COL6A6 RAPGEF1 RAPGEF1 XIAP XIAP FLNB FLNB PTK2 PTK2 COL6A2 COL6A2 PPP1R12B PPP1R12B RAC2 RAC2 H920_19642 H920_19642 LAMB2 LAMB2 PDGFC PDGFC MYLK2 MYLK2 UMOD UMOD LAMC1 LAMC1 VEGFC VEGFC MYLK4 MYLK4 VWA2 VWA2 ENSFDAP00000016516 ENSFDAP00000016516 ITGA11 ITGA11 Cdc42 Cdc42 PTEN PTEN TLN2 TLN2 OTOGL OTOGL Ccnd3 Ccnd3 LOC104870857 LOC104870857 Rap1b Rap1b PPP1R12C PPP1R12C Itgb3 Itgb3 VCL VCL COL1A1 COL1A1 MYL10 MYL10 PRKCG PRKCG ITGB8 ITGB8 ARHGAP35 ARHGAP35 DOCK1 DOCK1 MST1 MST1 Vegfa Vegfa LOC104856231 LOC104856231 PARVG PARVG ACTRT1 ACTRT1 PPP1R12A PPP1R12A ACTRT2 ACTRT2 CRKL CRKL ITGA7 ITGA7 H920_08687 H920_08687 PIP5K1C PIP5K1C NEDD9 NEDD9 MYL9 MYL9 THBS1 THBS1 TNXB TNXB PTK6 PTK6 ILK ILK Col9a1 Col9a1 Muc2 Muc2 ERBB2 ERBB2 LAMA3 LAMA3 H920_12193 H920_12193 H920_09656 H920_09656 PIK3CD PIK3CD ITGA6 ITGA6 Actb Actb LRRC45 LRRC45 HRAS HRAS VTN VTN GSK3B GSK3B ENSFDAP00000012096 ENSFDAP00000012096 MET MET TNC TNC COL1A2 COL1A2 CAV2 CAV2 PAK2 PAK2 FYN FYN ROCK2 ROCK2 CAPN2 CAPN2 FLT4 FLT4 AKT3 AKT3 Itga9 Itga9 MAPK9 MAPK9 ITGA3 ITGA3 ENSFDAP00000010317 ENSFDAP00000010317 MYLK MYLK Shc2 Shc2 ELK1 ELK1 LAMA1 LAMA1 ITGA4 ITGA4 PPP1R14B PPP1R14B VAV1 VAV1 PARVB PARVB PPP1CB PPP1CB CHAD CHAD THBS2 THBS2 PAK4 PAK4 MYL12B MYL12B RPS6KL1 RPS6KL1 ITGAV ITGAV MYL2 MYL2 COMP COMP IBSP IBSP H920_05210 H920_05210 ITGA1 ITGA1 Pik3r3 Pik3r3 THBS4 THBS4 MYLPF MYLPF VAV2 VAV2 SOS2 SOS2 PARVA PARVA PAK1 PAK1 ENSFDAP00000008900 ENSFDAP00000008900 COL4A6 COL4A6 LOC104858517 LOC104858517 DIAPH1 DIAPH1 JUN JUN PIP5K1A PIP5K1A SOS1 SOS1 ENSFDAP00000006459 ENSFDAP00000006459 THBS3 THBS3 ITGB7 ITGB7 MAP2K1 MAP2K1 IGF1R IGF1R LAMC3 LAMC3 PRKCB PRKCB PIP5K1B PIP5K1B BAD BAD PDGFA PDGFA OTOG OTOG Col6a1 Col6a1 COL4A1 COL4A1 LPXN LPXN RAC1 RAC1 GRB2 GRB2 Rhoc Rhoc PGF PGF LAMA4 LAMA4 MAPK8 MAPK8 Gp2 Gp2 AKT1 AKT1 BIRC3 BIRC3 VEGFB VEGFB EGFR EGFR ENSFDAP00000003664 ENSFDAP00000003664 PDPK1 PDPK1 BCAR1 BCAR1 SRMS SRMS Ccnd2 Ccnd2 PXN PXN ITGB5 ITGB5 VAV3 VAV3 ROCK1 ROCK1 RAF1 RAF1 ACTN4 ACTN4 SPP1 SPP1 ENSFDAP00000002352 ENSFDAP00000002352 ENSFDAP00000001943 ENSFDAP00000001943 MYL7 MYL7 VWF VWF DHX9 DHX9 PIK3CB PIK3CB VEGFD VEGFD COL2A1 COL2A1 BRAF BRAF PDGFD PDGFD COL6A3 COL6A3 CCND1 CCND1 ACTN1 ACTN1 EGF EGF RAC3 RAC3 RAP1A RAP1A IGF1 IGF1 ZYX ZYX PDGFB PDGFB AKT2 AKT2 PDGFRB PDGFRB FN1 FN1 ITGB4 ITGB4 SHC3 SHC3 RELN RELN BIRC2 BIRC2 PDGFRA PDGFRA LAMA5 LAMA5 ITGA2 ITGA2 CAV3 CAV3 RHOA RHOA ITGB1 ITGB1 PPP1CA PPP1CA PPP1CC PPP1CC ACTG1 ACTG1 ACTL8 ACTL8 LAMC2 LAMC2 PAK5 PAK5 ITGB6 ITGB6 ITGA10 ITGA10 COL9A3 COL9A3 H920_09510 H920_09510 PIK3R1 PIK3R1 SHC1 SHC1 FLT1 FLT1 ITGA8 ITGA8 MAPK10 MAPK10 MAPK1 MAPK1 PIK3CA PIK3CA CAV1 CAV1 MYLK3 MYLK3 LAMB3 LAMB3 Pik3r2 Pik3r2 KDR KDR FLNA FLNA MAPK3 MAPK3 Ctnnb1 Ctnnb1 CRK CRK FLNC FLNC Mff Mff HGF HGF ITGA5 ITGA5 TNR TNR ARHGAP5 ARHGAP5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ELK3ETS domain-containing protein Elk-3. (402 aa)
TLN1Talin-1. (2541 aa)
PRKCAProtein kinase C alpha type. (672 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
COL6A6Collagen alpha-6(VI) chain. (2247 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1211 aa)
XIAPBaculoviral IAP repeat-containing protein 4. (497 aa)
FLNBFilamin-B. (2602 aa)
PTK2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1083 aa)
COL6A2Collagen alpha-2(VI) chain. (1020 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (996 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
H920_19642Vasodilator-stimulated phosphoprotein. (108 aa)
LAMB2Laminin subunit beta-2. (1801 aa)
PDGFCPlatelet-derived growth factor C. (305 aa)
MYLK2Myosin light chain kinase 2. (579 aa)
UMODUromodulin. (500 aa)
LAMC1Laminin subunit gamma-1. (1576 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (373 aa)
MYLK4Myosin light chain kinase family member 4. (387 aa)
VWA2Von Willebrand factor A domain containing 2. (769 aa)
ENSFDAP00000016516annotation not available (156 aa)
ITGA11Integrin alpha-11; Belongs to the integrin alpha chain family. (1188 aa)
Cdc42Cell division control protein 42 like protein. (191 aa)
PTENPhosphatase and tensin homolog. (403 aa)
TLN2Talin-2. (2542 aa)
OTOGLOtogelin like. (2332 aa)
Ccnd3G1/S-specific cyclin-D3; Belongs to the cyclin family. (96 aa)
LOC104870857Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like. (486 aa)
Rap1bRas-related protein Rap-1b. (184 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (671 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (761 aa)
VCLVinculin. (1138 aa)
COL1A1Collagen alpha-1(I) chain. (1453 aa)
MYL10Myosin regulatory light chain 10. (147 aa)
PRKCGProtein kinase C. (680 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (768 aa)
ARHGAP35Rho GTPase activating protein 35. (1522 aa)
DOCK1Dedicator of cytokinesis protein 1; Belongs to the DOCK family. (1841 aa)
MST1Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (711 aa)
VegfaVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (186 aa)
LOC104856231Actin; Belongs to the actin family. (945 aa)
PARVGParvin gamma. (332 aa)
ACTRT1Actin-related protein T1; Belongs to the actin family. (377 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1005 aa)
ACTRT2Actin-related protein T2; Belongs to the actin family. (377 aa)
CRKLCrk-like protein. (303 aa)
ITGA7Integrin alpha-7; Belongs to the integrin alpha chain family. (1137 aa)
H920_08687Integrin alpha-9; Belongs to the integrin alpha chain family. (234 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (649 aa)
NEDD9Enhancer of filamentation 1. (833 aa)
MYL9Myosin light chain 9. (172 aa)
THBS1Thrombospondin-1. (1181 aa)
TNXBTenascin XB. (527 aa)
PTK6Protein-tyrosine kinase 6. (451 aa)
ILKIntegrin-linked protein kinase. (452 aa)
Col9a1Collagen alpha-1(IX) chain. (910 aa)
Muc2Mucin-2. (476 aa)
ERBB2Receptor protein-tyrosine kinase. (1212 aa)
LAMA3Laminin subunit alpha-3. (2791 aa)
H920_12193Actin, cytoplasmic type 8; Belongs to the actin family. (187 aa)
H920_09656Catenin beta-1. (83 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
ITGA6Integrin alpha-6; Belongs to the integrin alpha chain family. (1063 aa)
ActbActin, cytoplasmic 1. (375 aa)
LRRC45Leucine-rich repeat-containing protein 45. (662 aa)
HRASHRas proto-oncogene, GTPase. (191 aa)
VTNVitronectin. (431 aa)
GSK3BGlycogen synthase kinase 3 beta. (442 aa)
ENSFDAP00000012096annotation not available (135 aa)
METHepatocyte growth factor receptor. (1382 aa)
TNCTenascin. (2201 aa)
COL1A2Collagen alpha-2(I) chain. (1366 aa)
CAV2Caveolin 2. (143 aa)
PAK2Non-specific serine/threonine protein kinase. (525 aa)
FYNTyrosine-protein kinase. (537 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2. (1348 aa)
CAPN2Calpain-2 catalytic subunit; Belongs to the peptidase C2 family. (597 aa)
FLT4Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1361 aa)
AKT3Non-specific serine/threonine protein kinase. (480 aa)
Itga9Integrin alpha-9; Belongs to the integrin alpha chain family. (973 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ITGA3Integrin alpha-3; Belongs to the integrin alpha chain family. (1000 aa)
ENSFDAP00000010317annotation not available (274 aa)
MYLKMyosin light chain kinase, smooth muscle. (1926 aa)
Shc2SHC-transforming protein 2. (421 aa)
ELK1ETS domain-containing protein Elk-1. (427 aa)
LAMA1Laminin subunit alpha-1. (2977 aa)
ITGA4Integrin alpha-4; Belongs to the integrin alpha chain family. (967 aa)
PPP1R14BProtein phosphatase 1 regulatory subunit 14B. (122 aa)
VAV1Proto-oncogene vav. (714 aa)
PARVBParvin beta. (326 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (312 aa)
CHADChondroadherin. (348 aa)
THBS2Thrombospondin-2. (1172 aa)
PAK4Non-specific serine/threonine protein kinase. (595 aa)
MYL12BMyosin regulatory light polypeptide 9. (172 aa)
RPS6KL1Ribosomal protein S6 kinase-like 1; Belongs to the PDGF/VEGF growth factor family. (551 aa)
ITGAVIntegrin alpha-V; Belongs to the integrin alpha chain family. (996 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
COMPCartilage oligomeric matrix protein. (712 aa)
IBSPBone sialoprotein 2. (323 aa)
H920_05210Actin-41; Belongs to the actin family. (193 aa)
ITGA1Integrin subunit alpha 1. (1175 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
THBS4Thrombospondin-4. (901 aa)
MYLPFMyosin regulatory light chain 2, skeletal muscle isoform type 2. (170 aa)
VAV2Guanine nucleotide exchange factor VAV2. (771 aa)
SOS2Son of sevenless like protein 2. (1310 aa)
PARVAAlpha-parvin. (372 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ENSFDAP00000008900annotation not available (172 aa)
COL4A6Collagen alpha-2(IV) chain. (1685 aa)
LOC104858517Laminin subunit alpha-2. (1355 aa)
DIAPH1Protein diaphanous like protein 1. (1229 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (254 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type-1 alpha. (548 aa)
SOS1Son of sevenless like protein 1. (1289 aa)
ENSFDAP00000006459annotation not available (432 aa)
THBS3Thrombospondin-3. (956 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (736 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (388 aa)
IGF1RInsulin like growth factor 1 receptor. (1107 aa)
LAMC3Laminin subunit gamma-3. (1248 aa)
PRKCBProtein kinase C beta type. (586 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type-1 beta. (543 aa)
BADBcl2 antagonist of cell death. (162 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (207 aa)
OTOGOtogelin. (2853 aa)
Col6a1Collagen alpha-1(VI) chain. (1027 aa)
COL4A1Collagen alpha-1(IV) chain. (1490 aa)
LPXNLeupaxin. (380 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (199 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
RhocRas homolog family member C. (193 aa)
PGFPlacental growth factor. (161 aa)
LAMA4Laminin subunit alpha-4. (1464 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
Gp2Pancreatic secretory granule membrane major glycoprotein GP2. (537 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (644 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (168 aa)
EGFRReceptor protein-tyrosine kinase. (1168 aa)
ENSFDAP00000003664annotation not available (75 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (558 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1. (870 aa)
SRMSSrc-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites. (468 aa)
Ccnd2G1/S-specific cyclin-D2; Belongs to the cyclin family. (288 aa)
PXNPaxillin. (585 aa)
ITGB5Integrin subunit beta 5. (794 aa)
VAV3Guanine nucleotide exchange factor VAV3. (779 aa)
ROCK1Rho-associated protein kinase 1; Belongs to the peptidase C19 family. (1368 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
ACTN4Alpha-actinin-4. (908 aa)
SPP1Osteopontin. (344 aa)
ENSFDAP00000002352annotation not available (382 aa)
ENSFDAP00000001943annotation not available (152 aa)
MYL7Myosin light chain 7. (148 aa)
VWFVon Willebrand factor. (2568 aa)
DHX9ATP-dependent RNA helicase A. (1368 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
COL2A1Collagen alpha-1(II) chain. (1487 aa)
BRAFSerine/threonine-protein kinase B-raf. (740 aa)
PDGFDPlatelet-derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
COL6A3Collagen alpha-3(VI) chain. (2515 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
ACTN1Alpha-actinin-1. (892 aa)
EGFPro-epidermal growth factor. (1155 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (190 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
IGF1Insulin-like growth factor I. (158 aa)
ZYXZyxin. (534 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1097 aa)
FN1Fibronectin. (2477 aa)
ITGB4Integrin beta. (1761 aa)
SHC3SHC-transforming protein 3. (443 aa)
RELNReelin. (2792 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (618 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
LAMA5Laminin subunit alpha-5. (3409 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1179 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
RHOATransforming protein RhoA. (193 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (803 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (317 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
ACTG1Actin, cytoplasmic 2. (375 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (365 aa)
LAMC2Laminin subunit gamma-2. (1187 aa)
PAK5Non-specific serine/threonine protein kinase. (604 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (807 aa)
ITGA10Integrin alpha-10; Belongs to the integrin alpha chain family. (1166 aa)
COL9A3Collagen type IX alpha 3 chain. (657 aa)
H920_09510Reelin. (279 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
SHC1SHC-transforming protein 1. (583 aa)
FLT1Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1311 aa)
ITGA8Integrin alpha-8; Belongs to the integrin alpha chain family. (992 aa)
MAPK10Mitogen-activated protein kinase. (478 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
MYLK3Putative myosin light chain kinase 3. (778 aa)
LAMB3Laminin subunit beta-3. (1169 aa)
Pik3r2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1346 aa)
FLNAFilamin-A. (2647 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
Ctnnb1Catenin beta-1. (781 aa)
CRKCRK proto-oncogene, adaptor protein. (247 aa)
FLNCFilamin-C. (2726 aa)
MffMitochondrial fission factor. (316 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (725 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (991 aa)
TNRTenascin-R. (1358 aa)
ARHGAP5Rho GTPase-activating protein 5. (1503 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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