(64 nodes) RIG-I-like receptor signaling pathway network (Fukomys damarensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	OTUD5	OTU domain-containing protein 5. (370 aa)
	AZI2	5-azacytidine-induced protein 2. (405 aa)
	SIKE1	Suppressor of IKBKE 1. (207 aa)
	TKFC	Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (Cyclizing). (563 aa)
	TRIM65	Tripartite motif-containing protein 65. (403 aa)
	MAPK12	Mitogen-activated protein kinase 12. (316 aa)
	ENSFDAP00000004059	annotation not available (152 aa)
	DDX3Y	ATP-dependent RNA helicase DDX3Y; Belongs to the DEAD box helicase family. (645 aa)
	IFIH1	Interferon-induced helicase C domain-containing protein 1. (1026 aa)
	MAVS	Mitochondrial antiviral-signaling protein. (507 aa)
	H920_06528	Interferon kappa. (242 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
	MAPK13	Mitogen-activated protein kinase 13. (323 aa)
	LOC104854401	Probable ATP-dependent RNA helicase DDX58. (520 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	STING1	Transmembrane protein 173. (378 aa)
	Ddx3x	ATP-dependent RNA helicase DDX3X; Belongs to the DEAD box helicase family. (662 aa)
	NLRX1	NLR family member X1. (972 aa)
	Ikbke	Inhibitor of nuclear factor kappa-B kinase subunit epsilon. (130 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	TANK	TRAF family member-associated NF-kappa-B activator. (425 aa)
	RNF135	Ring finger protein 135. (389 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (240 aa)
	TRADD	Tumor necrosis factor receptor type 1-associated DEATH domain protein. (310 aa)
	MAPK14	Mitogen-activated protein kinase. (321 aa)
	RNF125	E3 ubiquitin-protein ligase RNF125. (138 aa)
	RELA	Transcription factor p65. (545 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (141 aa)
	TRIM47	Tripartite motif-containing protein 47. (448 aa)
	ENSFDAP00000007466	annotation not available (44 aa)
	TRIM25	E3 ubiquitin/ISG15 ligase TRIM25. (561 aa)
	DHX58	Putative ATP-dependent RNA helicase DHX58. (776 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1347 aa)
	ENSFDAP00000010317	annotation not available (274 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1. (660 aa)
	MAPK11	Mitogen-activated protein kinase 11. (325 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	IFNB1	Interferon beta. (187 aa)
	Atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (198 aa)
	CXCL10	C-X-C motif chemokine. (95 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7. (606 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
	NFKBIA	NF-kappa-B inhibitor alpha. (224 aa)
	IRF7	Interferon regulatory factor 7. (430 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
	Chuk	Inhibitor of nuclear factor kappa-B kinase subunit alpha. (744 aa)
	CASP8	Caspase-8; Belongs to the peptidase C14A family. (462 aa)
	FGFR1OP2	FGFR1 oncogene partner 2. (253 aa)
	IRF3	Interferon regulatory factor 3. (428 aa)
	ENSFDAP00000017499	annotation not available (530 aa)
	ENSFDAP00000017826	annotation not available (133 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit. (894 aa)
	TBK1	Serine/threonine-protein kinase TBK1. (729 aa)
	COIL	Coilin. (582 aa)
	ENSFDAP00000018123	annotation not available (101 aa)
	ENSFDAP00000018414	annotation not available (666 aa)
	NFKBIB	NF-kappa-B inhibitor beta. (358 aa)
	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (951 aa)
	MAPK10	Mitogen-activated protein kinase. (478 aa)
	IKBKG	NF-kappa-B essential modulator. (417 aa)

Your Current Organism:

Fukomys damarensis

NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	Atg5	ENSFDAP00000006620	ENSFDAP00000013584	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.994
ATG12	CASP8	ENSFDAP00000006620	ENSFDAP00000016683	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Caspase-8; Belongs to the peptidase C14A family.	0.551
ATG12	DHX58	ENSFDAP00000006620	ENSFDAP00000010233	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Putative ATP-dependent RNA helicase DHX58.	0.803
ATG12	ENSFDAP00000007466	ENSFDAP00000006620	ENSFDAP00000007466	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	annotation not available	0.994
ATG12	ENSFDAP00000017826	ENSFDAP00000006620	ENSFDAP00000017826	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	annotation not available	0.994
ATG12	FADD	ENSFDAP00000006620	ENSFDAP00000000029	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.711
ATG12	IFIH1	ENSFDAP00000006620	ENSFDAP00000003758	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Interferon-induced helicase C domain-containing protein 1.	0.909
ATG12	LOC104854401	ENSFDAP00000006620	ENSFDAP00000002186	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Probable ATP-dependent RNA helicase DDX58.	0.968
ATG12	MAVS	ENSFDAP00000006620	ENSFDAP00000003691	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Mitochondrial antiviral-signaling protein.	0.975
ATG12	NLRX1	ENSFDAP00000006620	ENSFDAP00000001485	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family member X1.	0.714
AZI2	Chuk	ENSFDAP00000021374	ENSFDAP00000016676	5-azacytidine-induced protein 2.	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	0.646
AZI2	ENSFDAP00000018414	ENSFDAP00000021374	ENSFDAP00000018414	5-azacytidine-induced protein 2.	annotation not available	0.646
AZI2	IKBKB	ENSFDAP00000021374	ENSFDAP00000002634	5-azacytidine-induced protein 2.	Inhibitor of nuclear factor kappa-B kinase subunit beta.	0.646
AZI2	IKBKG	ENSFDAP00000021374	ENSFDAP00000020434	5-azacytidine-induced protein 2.	NF-kappa-B essential modulator.	0.867
AZI2	Ikbke	ENSFDAP00000021374	ENSFDAP00000001268	5-azacytidine-induced protein 2.	Inhibitor of nuclear factor kappa-B kinase subunit epsilon.	0.955
AZI2	TANK	ENSFDAP00000021374	ENSFDAP00000000065	5-azacytidine-induced protein 2.	TRAF family member-associated NF-kappa-B activator.	0.921
AZI2	TBK1	ENSFDAP00000021374	ENSFDAP00000017895	5-azacytidine-induced protein 2.	Serine/threonine-protein kinase TBK1.	0.993
AZI2	TNF	ENSFDAP00000021374	ENSFDAP00000004384	5-azacytidine-induced protein 2.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.943
AZI2	TRAF3	ENSFDAP00000021374	ENSFDAP00000001880	5-azacytidine-induced protein 2.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.455
Atg5	ATG12	ENSFDAP00000013584	ENSFDAP00000006620	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.994