STRINGSTRING
SH2D1A SH2D1A NRAS NRAS H920_17964 H920_17964 CD247 CD247 SHC3 SHC3 SH3BP2 SH3BP2 ITGAL ITGAL IFNGR2 IFNGR2 H920_17962 H920_17962 CSDE1 CSDE1 PIK3R1 PIK3R1 SHC1 SHC1 PLCG1 PLCG1 MAPK1 MAPK1 PIK3CA PIK3CA Pik3r2 Pik3r2 MAPK3 MAPK3 KLRD1 KLRD1 ICAM1 ICAM1 PRKCA PRKCA CSF2 CSF2 PPP3R1 PPP3R1 LOC104864184 LOC104864184 RAC2 RAC2 H920_04312 H920_04312 LOC104857295 LOC104857295 ARAF ARAF H920_17965 H920_17965 LOC104864167 LOC104864167 H920_10546 H920_10546 PTK2B PTK2B Bid Bid H920_17960 H920_17960 PRKCG PRKCG GZMH GZMH H920_01787 H920_01787 ICAM2 ICAM2 ENSFDAP00000014417 ENSFDAP00000014417 LCP2 LCP2 IFNAR1 IFNAR1 ENSFDAP00000013841 ENSFDAP00000013841 ZAP70 ZAP70 PTK6 PTK6 KRAS KRAS PIK3CD PIK3CD Faslg Faslg SYK SYK HRAS HRAS PTPN6 PTPN6 ENSFDAP00000012168 ENSFDAP00000012168 HCST HCST PPP3CA PPP3CA IFNB1 IFNB1 FYN FYN H920_13644 H920_13644 H920_07367 H920_07367 H920_03480 H920_03480 H920_04309 H920_04309 Shc2 Shc2 NFATC2 NFATC2 H920_04300 H920_04300 H920_00188 H920_00188 Casp3 Casp3 KLRG1 KLRG1 PAK1 PAK1 SOS2 SOS2 VAV2 VAV2 Pik3r3 Pik3r3 H920_13645 H920_13645 H920_04299 H920_04299 H920_04301 H920_04301 LOC104859319 LOC104859319 KLRK1 KLRK1 TNFSF10 TNFSF10 VAV1 VAV1 SOS1 SOS1 PPP3CB PPP3CB NFATC1 NFATC1 MAP2K1 MAP2K1 LCK LCK PRKCB PRKCB Fas Fas RAC1 RAC1 FCER1G FCER1G GRB2 GRB2 PRF1 PRF1 TNF TNF Treml4 Treml4 LOC104864185 LOC104864185 TYROBP TYROBP SRMS SRMS Map2k2 Map2k2 VAV3 VAV3 RAF1 RAF1 Itgb2 Itgb2 PPP3CC PPP3CC PIK3CB PIK3CB Cd48 Cd48 H920_13310 H920_13310 BRAF BRAF IFNG IFNG PTPN11 PTPN11 RAC3 RAC3 Tnfrsf10b Tnfrsf10b LOC104852000 LOC104852000
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SH2D1ASH2 domain containing 1A. (127 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
H920_17964Ig heavy chain V region 1B43. (121 aa)
CD247T-cell surface glycoprotein CD3 zeta chain. (164 aa)
SHC3SHC-transforming protein 3. (443 aa)
SH3BP2SH3 domain-binding protein 2. (623 aa)
ITGALIntegrin alpha-L; Belongs to the integrin alpha chain family. (1138 aa)
IFNGR2Interferon gamma receptor 2. (319 aa)
H920_17962Ig heavy chain V region 1B43. (122 aa)
CSDE1Cold shock domain-containing protein E1. (798 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
SHC1SHC-transforming protein 1. (583 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Pik3r2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
KLRD1Killer cell lectin like receptor D1. (179 aa)
ICAM1Intercellular adhesion molecule 1. (500 aa)
PRKCAProtein kinase C alpha type. (672 aa)
CSF2Uncharacterized protein. (144 aa)
PPP3R1Calcineurin subunit B type 1. (164 aa)
LOC104864184Granzyme B(G,H); Belongs to the peptidase S1 family. (235 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
H920_04312Ig heavy chain V-III region VH26. (180 aa)
LOC104857295Low affinity immunoglobulin gamma Fc region receptor III-B. (260 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
H920_17965Ig heavy chain V region 1B43. (122 aa)
LOC104864167Granzyme B; Belongs to the peptidase S1 family. (247 aa)
H920_10546Ig heavy chain V-III region VH26. (184 aa)
PTK2BProtein-tyrosine kinase 2-beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
BidBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (187 aa)
H920_17960Ig heavy chain V region 1B43. (137 aa)
PRKCGProtein kinase C. (680 aa)
GZMHGranzyme H; Belongs to the peptidase S1 family. (245 aa)
H920_01787Ig heavy chain V region 441. (173 aa)
ICAM2Intercellular adhesion molecule 2. (278 aa)
ENSFDAP00000014417annotation not available (184 aa)
LCP2Lymphocyte cytosolic protein 2. (520 aa)
IFNAR1Interferon alpha/beta receptor 1. (492 aa)
ENSFDAP00000013841annotation not available (257 aa)
ZAP70Tyrosine-protein kinase. (576 aa)
PTK6Protein-tyrosine kinase 6. (451 aa)
KRASGTPase HRas. (189 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
FaslgTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (69 aa)
SYKTyrosine-protein kinase. (629 aa)
HRASHRas proto-oncogene, GTPase. (191 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
ENSFDAP00000012168annotation not available (120 aa)
HCSTHematopoietic cell signal transducer. (73 aa)
PPP3CASerine/threonine-protein phosphatase. (501 aa)
IFNB1Interferon beta. (187 aa)
FYNTyrosine-protein kinase. (537 aa)
H920_13644Ig heavy chain V region M315. (122 aa)
H920_07367Ig heavy chain V region M167. (113 aa)
H920_03480Ig heavy chain V-III region VH26. (176 aa)
H920_04309Ig heavy chain V region 1B43. (122 aa)
Shc2SHC-transforming protein 2. (421 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2. (850 aa)
H920_04300Ig heavy chain V-III region VH26. (143 aa)
H920_00188SH2 domain-containing protein 1B. (83 aa)
Casp3Caspase-3; Belongs to the peptidase C14A family. (277 aa)
KLRG1Killer cell lectin like receptor G1. (189 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
SOS2Son of sevenless like protein 2. (1310 aa)
VAV2Guanine nucleotide exchange factor VAV2. (771 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
H920_13645Ig heavy chain V region M315. (120 aa)
H920_04299Ig heavy chain V region 1B43. (122 aa)
H920_04301Ig heavy chain V-II region SESS. (170 aa)
LOC104859319NKG2D ligand 1. (247 aa)
KLRK1NKG2-D type II integral membrane protein. (215 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (289 aa)
VAV1Proto-oncogene vav. (714 aa)
SOS1Son of sevenless like protein 1. (1289 aa)
PPP3CBSerine/threonine-protein phosphatase. (499 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (783 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (388 aa)
LCKTyrosine-protein kinase. (506 aa)
PRKCBProtein kinase C beta type. (586 aa)
FasTumor necrosis factor receptor superfamily member 6. (290 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (199 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PRF1Perforin-1. (554 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
Treml4Trem-like transcript 4 protein. (203 aa)
LOC104864185Granzyme-like protein 1; Belongs to the peptidase S1 family. (254 aa)
TYROBPTYRO protein tyrosine kinase-binding protein. (111 aa)
SRMSSrc-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites. (468 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (370 aa)
VAV3Guanine nucleotide exchange factor VAV3. (779 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
Itgb2Integrin beta. (461 aa)
PPP3CCSerine/threonine-protein phosphatase. (493 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
Cd48CD48 molecule. (243 aa)
H920_13310Ig heavy chain V-III region VH26. (180 aa)
BRAFSerine/threonine-protein kinase B-raf. (740 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (600 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (190 aa)
Tnfrsf10bTumor necrosis factor receptor superfamily member 10B. (417 aa)
LOC1048520001-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1255 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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