STRINGSTRING
LOC104874367 LOC104874367 MAPK12 MAPK12 NRAS NRAS AKT2 AKT2 FN1 FN1 PLCD1 PLCD1 NOX1 NOX1 PLCD4 PLCD4 CDKN1B CDKN1B AGER AGER CSDE1 CSDE1 PLCE1 PLCE1 TGFB1 TGFB1 PIK3R1 PIK3R1 SMAD4 SMAD4 CYBB CYBB MAPK10 MAPK10 PLCG1 PLCG1 COL3A1 COL3A1 MAPK1 MAPK1 PIK3CA PIK3CA Pik3r2 Pik3r2 PIM1 PIM1 EGR1 EGR1 MAPK3 MAPK3 EDN1 EDN1 AGT AGT Mff Mff ICAM1 ICAM1 PRKCA PRKCA Il1b Il1b JAK2 JAK2 F3 F3 NFKB1 NFKB1 STAT3 STAT3 VEGFC VEGFC SERPINE1 SERPINE1 ENSFDAP00000016516 ENSFDAP00000016516 MMP2 MMP2 Cdc42 Cdc42 COL1A1 COL1A1 SMAD2 SMAD2 Vegfa Vegfa TGFB3 TGFB3 ENSFDAP00000013841 ENSFDAP00000013841 KRAS KRAS TGFBR1 TGFBR1 FOXO1 FOXO1 Stat5b Stat5b PIK3CD PIK3CD HRAS HRAS COL1A2 COL1A2 CXCL8 CXCL8 PLCB2 PLCB2 PLCB3 PLCB3 AKT3 AKT3 MAPK9 MAPK9 MAPK11 MAPK11 NOX4 NOX4 ENSFDAP00000010317 ENSFDAP00000010317 SELE SELE AGTR1 AGTR1 Casp3 Casp3 JUN JUN DIAPH1 DIAPH1 COL4A6 COL4A6 PLCB1 PLCB1 ENSFDAP00000008900 ENSFDAP00000008900 Vcam1 Vcam1 XK XK IL1A IL1A Pik3r3 Pik3r3 NOX3 NOX3 NOS3 NOS3 PRKCD PRKCD RELA RELA NFATC1 NFATC1 PLCB4 PLCB4 PRKCB PRKCB SMAD3 SMAD3 MAPK14 MAPK14 COL4A1 COL4A1 RAC1 RAC1 MAPK8 MAPK8 TNF TNF PRKCE PRKCE AKT1 AKT1 VEGFB VEGFB TGFB2 TGFB2 TGFBR2 TGFBR2 MAPK13 MAPK13 ENSFDAP00000001943 ENSFDAP00000001943 PIK3CB PIK3CB CDK4 CDK4 VEGFD VEGFD STAT1 STAT1 CCND1 CCND1 BAX BAX LOC104852000 LOC104852000
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC104874367C-C motif chemokine. (119 aa)
MAPK12Mitogen-activated protein kinase 12. (316 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
FN1Fibronectin. (2477 aa)
PLCD1Phosphoinositide phospholipase C. (755 aa)
NOX1NADPH oxidase 1. (564 aa)
PLCD4Phosphoinositide phospholipase C. (756 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
AGERAdvanced glycosylation end product-specific receptor. (418 aa)
CSDE1Cold shock domain-containing protein E1. (798 aa)
PLCE1Phosphoinositide phospholipase C. (2298 aa)
TGFB1Transforming growth factor beta-1. (333 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CYBBCytochrome b-245 heavy chain. (570 aa)
MAPK10Mitogen-activated protein kinase. (478 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
COL3A1Collagen alpha-1(III) chain. (1463 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Pik3r2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
PIM1Proto-oncogene serine/threonine-protein kinase pim-1. (208 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (541 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
EDN1Endothelin-1. (203 aa)
AGTAngiotensinogen; Belongs to the serpin family. (478 aa)
MffMitochondrial fission factor. (316 aa)
ICAM1Intercellular adhesion molecule 1. (500 aa)
PRKCAProtein kinase C alpha type. (672 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (329 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (894 aa)
STAT3Signal transducer and activator of transcription. (758 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (373 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
ENSFDAP00000016516annotation not available (156 aa)
MMP2Matrix metallopeptidase 2. (644 aa)
Cdc42Cell division control protein 42 like protein. (191 aa)
COL1A1Collagen alpha-1(I) chain. (1453 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
VegfaVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (186 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ENSFDAP00000013841annotation not available (257 aa)
KRASGTPase HRas. (189 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (470 aa)
FOXO1Forkhead box protein O1. (522 aa)
Stat5bSignal transducer and activator of transcription 5B. (736 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
HRASHRas proto-oncogene, GTPase. (191 aa)
COL1A2Collagen alpha-2(I) chain. (1366 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1158 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1197 aa)
AKT3Non-specific serine/threonine protein kinase. (480 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPK11Mitogen-activated protein kinase 11. (325 aa)
NOX4NADPH oxidase 4. (559 aa)
ENSFDAP00000010317annotation not available (274 aa)
SELEE-selectin. (617 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
Casp3Caspase-3; Belongs to the peptidase C14A family. (277 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (254 aa)
DIAPH1Protein diaphanous like protein 1. (1229 aa)
COL4A6Collagen alpha-2(IV) chain. (1685 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
ENSFDAP00000008900annotation not available (172 aa)
Vcam1Vascular cell adhesion protein 1. (742 aa)
XKXK-related protein. (442 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
NOX3NADPH oxidase 3. (568 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1206 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
RELATranscription factor p65. (545 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (783 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
PRKCBProtein kinase C beta type. (586 aa)
SMAD3Mothers against decapentaplegic homolog. (429 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
COL4A1Collagen alpha-1(IV) chain. (1490 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (199 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (736 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (168 aa)
TGFB2Transforming growth factor beta 2. (398 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (560 aa)
MAPK13Mitogen-activated protein kinase 13. (323 aa)
ENSFDAP00000001943annotation not available (152 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
BAXApoptosis regulator BAX. (180 aa)
LOC1048520001-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1255 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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