STRINGSTRING
ADCY9 ADCY9 ADCY6 ADCY6 DVL2 DVL2 RASD1 RASD1 AXIN1 AXIN1 WDR5 WDR5 WNT2 WNT2 CREB3L1 CREB3L1 CDKN1B CDKN1B CAMK2G CAMK2G ENSFDAP00000020777 ENSFDAP00000020777 LOC104852325 LOC104852325 AIPL1 AIPL1 MAPK1 MAPK1 ENSFDAP00000020023 ENSFDAP00000020023 CACNA1C CACNA1C H920_06235 H920_06235 MAPK3 MAPK3 KCNA1 KCNA1 Ahr Ahr Ctnnb1 Ctnnb1 ATF2 ATF2 AGT AGT MEN1 MEN1 CRHR2 CRHR2 ADCY7 ADCY7 CACNA1F CACNA1F FZD3 FZD3 ARNT ARNT WNT10A WNT10A CACNA1H CACNA1H CREB3L4 CREB3L4 ITPR2 ITPR2 WNT7A WNT7A WNT5A WNT5A AIP AIP CYP17A1 CYP17A1 GNAI2 GNAI2 Rap1b Rap1b CREB3 CREB3 PTRHD1 PTRHD1 LOC104875819 LOC104875819 LDLR LDLR ARSI ARSI DVL1 DVL1 KCNA10 KCNA10 H920_05677 H920_05677 TCF7L1 TCF7L1 CREB5 CREB5 ASH2L ASH2L LOC104850622 LOC104850622 FZD4 FZD4 CDKN2C CDKN2C H920_09656 H920_09656 AXIN2 AXIN2 WNT8A WNT8A CREB3L3 CREB3L3 LEF1 LEF1 GSK3B GSK3B ENSFDAP00000012096 ENSFDAP00000012096 FZD8 FZD8 FZD7 FZD7 WNT3A WNT3A WDR5B WDR5B WNT10B WNT10B NR5A1 NR5A1 PLCB2 PLCB2 WNT2B WNT2B LOC104865308 LOC104865308 WNT11 WNT11 ITPR3 ITPR3 CRH CRH NR4A1 NR4A1 GNAQ GNAQ NCEH1 NCEH1 PBX1 PBX1 LOC104865357 LOC104865357 Pde8b Pde8b AGTR1 AGTR1 WNT1 WNT1 LOC104875818 LOC104875818 Mrap Mrap E2F3 E2F3 FH FH SP1 SP1 PLCB1 PLCB1 STAR STAR FZD6 FZD6 TCF7L2 TCF7L2 ADCY1 ADCY1 WNT4 WNT4 CACNA1I CACNA1I CACNA1S CACNA1S RBBP5 RBBP5 ATF6B ATF6B CREB1 CREB1 CAMK2B CAMK2B ADCY2 ADCY2 TCF7 TCF7 USP8 USP8 WNT6 WNT6 GNA11 GNA11 WNT9B WNT9B CCNE1 CCNE1 FZD1 FZD1 DVL3 DVL3 WNT5B WNT5B Camk2d Camk2d MAP2K1 MAP2K1 PLCB4 PLCB4 ADCY5 ADCY5 KCNA2 KCNA2 LOC104872874 LOC104872874 LOC104872873 LOC104872873 ITPR1 ITPR1 GNAI3 GNAI3 Kmt2a Kmt2a ADCY3 ADCY3 CDKN2B CDKN2B PRKACA PRKACA EGFR EGFR FZD9 FZD9 APC2 APC2 Map2k2 Map2k2 CDK2 CDK2 SCARB1 SCARB1 ADCY4 ADCY4 E2F1 E2F1 ADCY8 ADCY8 APC APC WNT9A WNT9A WNT3 WNT3 CDKN1A CDKN1A KCNK2 KCNK2 CACNA1G CACNA1G CREB3L2 CREB3L2 KMT2D KMT2D LOC104871533 LOC104871533 ORAI1 ORAI1 CYP11A1 CYP11A1 KCNA4 KCNA4 E2F2 E2F2 CDK4 CDK4 WNT16 WNT16 BRAF BRAF ATF4 ATF4 CACNA1D CACNA1D CCND1 CCND1 GNAI1 GNAI1 WNT7B WNT7B RB1 RB1 CCNE2 CCNE2 RAP1A RAP1A CAMK2A CAMK2A PDE8A PDE8A FZD10 FZD10 PLCB3 PLCB3 CDK6 CDK6 PRKACB PRKACB KCNA5 KCNA5 Pde11a Pde11a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1169 aa)
DVL2Segment polarity protein dishevelled like protein DVL-2. (736 aa)
RASD1Dexamethasone-induced Ras-related protein 1. (281 aa)
AXIN1Axin-1. (865 aa)
WDR5WD repeat-containing protein 5. (334 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (447 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (514 aa)
ENSFDAP00000020777annotation not available (90 aa)
LOC104852325Steroid 21-hydroxylase. (306 aa)
AIPL1Aryl-hydrocarbon-interacting protein-like 1. (328 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
ENSFDAP00000020023annotation not available (280 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2066 aa)
H920_06235Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (326 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
AhrAryl hydrocarbon receptor. (839 aa)
Ctnnb1Catenin beta-1. (781 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2. (505 aa)
AGTAngiotensinogen; Belongs to the serpin family. (478 aa)
MEN1Menin. (616 aa)
CRHR2Corticotropin-releasing factor receptor 2; Belongs to the G-protein coupled receptor 2 family. (419 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha-1F. (1950 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
ARNTUncharacterized protein. (780 aa)
WNT10AWnt family member 10A. (351 aa)
CACNA1HVoltage-dependent T-type calcium channel subunit alpha-1H. (2263 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (364 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
AIPAH receptor-interacting protein. (330 aa)
CYP17A1Steroid 17-alpha-hydroxylase/17,20 lyase; Belongs to the cytochrome P450 family. (419 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
Rap1bRas-related protein Rap-1b. (184 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (389 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
LOC1048758193 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase. (373 aa)
LDLRLow-density lipoprotein receptor. (779 aa)
ARSIArylsulfatase I. (575 aa)
DVL1Segment polarity protein dishevelled like protein DVL-1. (696 aa)
KCNA10Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family. (511 aa)
H920_05677Calcium/calmodulin-dependent protein kinase type II subunit beta. (144 aa)
TCF7L1Transcription factor 7-like 1. (453 aa)
CREB5cAMP responsive element binding protein 5. (508 aa)
ASH2LSet1/Ash2 histone methyltransferase complex subunit ASH2. (629 aa)
LOC104850622Guanine nucleotide-binding protein G(S) subunit alpha. (394 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (533 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
H920_09656Catenin beta-1. (83 aa)
AXIN2Axin-2. (860 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (432 aa)
LEF1Lymphoid enhancer-binding factor 1. (329 aa)
GSK3BGlycogen synthase kinase 3 beta. (442 aa)
ENSFDAP00000012096annotation not available (135 aa)
FZD8Frizzled class receptor 8. (409 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
WDR5BWD repeat-containing protein 5B. (324 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
NR5A1Steroidogenic factor 1. (461 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1158 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
LOC104865308Neuroendocrine secretory protein 55. (229 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2524 aa)
CRHCorticoliberin. (194 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (598 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (313 aa)
NCEH1Neutral cholesterol ester hydrolase 1. (408 aa)
PBX1Pre-B-cell leukemia transcription factor 1. (391 aa)
LOC104865357Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas. (347 aa)
Pde8bPhosphodiesterase. (771 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (322 aa)
LOC1048758183 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; Belongs to the 3-beta-HSD family. (373 aa)
MrapMelanocortin-2 receptor accessory protein. (116 aa)
E2F3Transcription factor E2F3. (334 aa)
FHFumarate hydratase, mitochondrial. (508 aa)
SP1Transcription factor Sp1. (784 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (596 aa)
TCF7L2Transcription factor 7 like 2. (413 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (944 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (327 aa)
CACNA1ICalcium voltage-gated channel subunit alpha1 I. (1988 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1788 aa)
RBBP5Retinoblastoma-binding protein 5. (545 aa)
ATF6BActivating transcription factor 6 beta. (621 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (341 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (359 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (964 aa)
TCF7Transcription factor 7. (302 aa)
USP8Ubiquitin carboxyl-terminal hydrolase 8; Belongs to the peptidase C19 family. (1080 aa)
WNT6Wnt family member 6. (363 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (313 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (405 aa)
FZD1Frizzled class receptor 1. (486 aa)
DVL3Segment polarity protein dishevelled like protein DVL-3. (606 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
Camk2dCalcium/calmodulin-dependent protein kinase type II subunit delta. (512 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (388 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ADCY5Adenylate cyclase type 5. (1182 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
LOC104872874Cytochrome P450 11B1, mitochondrial; Belongs to the cytochrome P450 family. (501 aa)
LOC104872873Cytochrome P450 11B1, mitochondrial; Belongs to the cytochrome P450 family. (501 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2758 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
Kmt2aHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3838 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1145 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (138 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha. (343 aa)
EGFRReceptor protein-tyrosine kinase. (1168 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (399 aa)
APC2Adenomatous polyposis coli protein 2. (1982 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (370 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (502 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1062 aa)
E2F1Transcription factor E2F1. (377 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1210 aa)
APCAdenomatous polyposis coli protein. (2857 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (165 aa)
KCNK2Potassium channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (424 aa)
CACNA1GCalcium voltage-gated channel subunit alpha1 G. (2301 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
KMT2DHistone-lysine N-methyltransferase MLL2. (5441 aa)
LOC104871533Corticotropin-releasing factor receptor 1; Belongs to the G-protein coupled receptor 2 family. (404 aa)
ORAI1Calcium release-activated calcium channel protein 1. (187 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (522 aa)
KCNA4Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (660 aa)
E2F2Transcription factor E2F2. (391 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
BRAFSerine/threonine-protein kinase B-raf. (740 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (352 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2165 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (314 aa)
WNT7BWnt family member 7B. (349 aa)
RB1Retinoblastoma-associated protein. (882 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (405 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha. (489 aa)
PDE8APhosphodiesterase. (772 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (545 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1197 aa)
CDK6Cyclin-dependent kinase 6. (296 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (396 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (398 aa)
Pde11aPhosphodiesterase. (529 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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