(38 nodes) Aldosterone-regulated sodium reabsorption network (Fukomys damarensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	Fxyd2	FXYD domain containing ion transport regulator 2. (64 aa)
	Insr	Tyrosine-protein kinase receptor. (1345 aa)
	NR3C2	Uncharacterized protein. (972 aa)
	ATP1B3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (243 aa)
	IGF1	Insulin-like growth factor I. (158 aa)
	HSD11B2	Corticosteroid 11-beta-dehydrogenase isozyme 2. (387 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
	ATP1A1	Sodium/potassium-transporting ATPase subunit alpha. (1025 aa)
	PRKCA	Protein kinase C alpha type. (672 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (252 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
	SCNN1A	Amiloride-sensitive sodium channel subunit alpha; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (585 aa)
	SCNN1G	Amiloride-sensitive sodium channel subunit gamma; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (690 aa)
	MAPK3	Mitogen-activated protein kinase. (322 aa)
	Fxyd4	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (72 aa)
	Pik3r2	Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	MAPK1	Mitogen-activated protein kinase. (320 aa)
	SGK1	Non-specific serine/threonine protein kinase. (526 aa)
	Scnn1d	Amiloride-sensitive sodium channel subunit delta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (550 aa)
	SCNN1B	Amiloride-sensitive sodium channel subunit beta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (644 aa)
	PRKCB	Protein kinase C beta type. (586 aa)
	ATP1B1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (268 aa)
	Atp1a3	Sodium/potassium-transporting ATPase subunit alpha. (1013 aa)
	KCNJ1	ATP-sensitive inward rectifier potassium channel 1. (391 aa)
	Pik3r3	Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
	ATP1A4	ATPase Na+/K+ transporting subunit alpha 4. (1026 aa)
	IRS1	Insulin receptor substrate 1. (1238 aa)
	ATP1B4	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (348 aa)
	SFN	14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
	ATP1A2	Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (1020 aa)
	SLC9A3R2	Na(+)/H(+) exchange regulatory cofactor NHE-RF2. (231 aa)
	PDPK1	3-phosphoinositide-dependent protein kinase 1. (558 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
	NEDD4L	E3 ubiquitin-protein ligase. (983 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	PRKCG	Protein kinase C. (680 aa)
	LOC104857865	Insulin receptor. (222 aa)

Your Current Organism:

Fukomys damarensis

NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP1A1	ATP1A2	ENSFDAP00000017712	ENSFDAP00000012109	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.922
ATP1A1	ATP1A4	ENSFDAP00000017712	ENSFDAP00000009283	Sodium/potassium-transporting ATPase subunit alpha.	ATPase Na+/K+ transporting subunit alpha 4.	0.823
ATP1A1	ATP1B1	ENSFDAP00000017712	ENSFDAP00000006748	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.993
ATP1A1	ATP1B2	ENSFDAP00000017712	ENSFDAP00000021158	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.946
ATP1A1	ATP1B3	ENSFDAP00000017712	ENSFDAP00000000167	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.957
ATP1A1	ATP1B4	ENSFDAP00000017712	ENSFDAP00000012029	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.957
ATP1A1	Atp1a3	ENSFDAP00000017712	ENSFDAP00000006753	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.875
ATP1A1	Fxyd2	ENSFDAP00000017712	ENSFDAP00000002434	Sodium/potassium-transporting ATPase subunit alpha.	FXYD domain containing ion transport regulator 2.	0.978
ATP1A1	Fxyd4	ENSFDAP00000017712	ENSFDAP00000019735	Sodium/potassium-transporting ATPase subunit alpha.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.478
ATP1A1	MAPK1	ENSFDAP00000017712	ENSFDAP00000020110	Sodium/potassium-transporting ATPase subunit alpha.	Mitogen-activated protein kinase.	0.916
ATP1A1	MAPK3	ENSFDAP00000017712	ENSFDAP00000019537	Sodium/potassium-transporting ATPase subunit alpha.	Mitogen-activated protein kinase.	0.916
ATP1A2	ATP1A1	ENSFDAP00000012109	ENSFDAP00000017712	Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Sodium/potassium-transporting ATPase subunit alpha.	0.922
ATP1A2	ATP1A4	ENSFDAP00000012109	ENSFDAP00000009283	Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	ATPase Na+/K+ transporting subunit alpha 4.	0.823
ATP1A2	ATP1B1	ENSFDAP00000012109	ENSFDAP00000006748	Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.992
ATP1A2	ATP1B2	ENSFDAP00000012109	ENSFDAP00000021158	Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.961
ATP1A2	ATP1B3	ENSFDAP00000012109	ENSFDAP00000000167	Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.940
ATP1A2	ATP1B4	ENSFDAP00000012109	ENSFDAP00000012029	Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.957
ATP1A2	Atp1a3	ENSFDAP00000012109	ENSFDAP00000006753	Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	Sodium/potassium-transporting ATPase subunit alpha.	0.887
ATP1A2	Fxyd2	ENSFDAP00000012109	ENSFDAP00000002434	Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	FXYD domain containing ion transport regulator 2.	0.978
ATP1A2	Fxyd4	ENSFDAP00000012109	ENSFDAP00000019735	Sodium/potassium-transporting ATPase subunit alpha-2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.478