STRINGSTRING
PIK3CD PIK3CD TGFBR1 TGFBR1 IL2 IL2 TGFB3 TGFB3 ENSFDAP00000004169 ENSFDAP00000004169 FADD FADD ENSFDAP00000000144 ENSFDAP00000000144 GNAI1 GNAI1 IFNG IFNG Map2k4 Map2k4 LOC104852640 LOC104852640 IL10 IL10 PIK3CB PIK3CB PPP2R2A PPP2R2A GNA15 GNA15 IRAK1 IRAK1 LOC104863058 LOC104863058 Ppp2r1a Ppp2r1a MAPK13 MAPK13 IKBKB IKBKB TGFBR2 TGFBR2 TGFB2 TGFB2 Irak4 Irak4 CD3D CD3D MAPK14 MAPK14 RELA RELA TLR4 TLR4 GNA11 GNA11 Pik3r3 Pik3r3 CFLAR CFLAR MYD88 MYD88 ADCY1 ADCY1 PPP2R2C PPP2R2C PLCB1 PLCB1 JUN JUN CD3G CD3G LOC104867412 LOC104867412 LOC104865357 LOC104865357 GNAQ GNAQ ENSFDAP00000010317 ENSFDAP00000010317 MAPK11 MAPK11 MAPK9 MAPK9 ENSFDAP00000011016 ENSFDAP00000011016 AKT3 AKT3 PLCB3 PLCB3 PPP2CB PPP2CB LOC104865308 LOC104865308 PLCB2 PLCB2 CXCL8 CXCL8 IFNB1 IFNB1 Faslg Faslg IFNGR2 IFNGR2 C1QC C1QC FOS FOS TGFB1 TGFB1 PIK3R1 PIK3R1 IKBKG IKBKG MAPK10 MAPK10 MAPK1 MAPK1 PIK3CA PIK3CA Pik3r2 Pik3r2 MAPK3 MAPK3 H920_05366 H920_05366 TRAV22 TRAV22 CALR CALR PPP2R1B PPP2R1B ACE ACE ENSFDAP00000018414 ENSFDAP00000018414 Il1b Il1b NOS2 NOS2 NFKB1 NFKB1 LOC104868943 LOC104868943 GNA14 GNA14 Ppp2ca Ppp2ca TRBV6-4 TRBV6-4 SERPINE1 SERPINE1 TRBV19 TRBV19 PPP2R2D PPP2R2D CASP8 CASP8 Chuk Chuk AADAC AADAC IL12B IL12B LOC104863125 LOC104863125 GNAI2 GNAI2 NFKBIA NFKBIA GNAL GNAL C3 C3 TRAF6 TRAF6 SMAD2 SMAD2 H920_02493 H920_02493 PPP2R2B PPP2R2B LOC104850622 LOC104850622 TNF TNF MAPK8 MAPK8 IL12A IL12A LOC104874367 LOC104874367 GNAI3 GNAI3 Fas Fas C1QB C1QB PLCB4 PLCB4 ENSFDAP00000002977 ENSFDAP00000002977 GNAO1 GNAO1 TLR2 TLR2 CD3E CD3E CCL5 CCL5 AKT1 AKT1 MAPK12 MAPK12 AKT2 AKT2 CD247 CD247
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (470 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (152 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ENSFDAP00000004169annotation not available (234 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
ENSFDAP00000000144annotation not available (263 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (314 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
Map2k4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (381 aa)
LOC104852640Calreticulin-like. (439 aa)
IL10Interleukin-10. (178 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform. (458 aa)
GNA15Guanine nucleotide-binding protein subunit alpha-15. (374 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (453 aa)
LOC104863058Arylacetamide deacetylase-like 2. (401 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (573 aa)
MAPK13Mitogen-activated protein kinase 13. (323 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (560 aa)
TGFB2Transforming growth factor beta 2. (398 aa)
Irak4Interleukin-1 receptor-associated kinase 4. (459 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (166 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
RELATranscription factor p65. (545 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (839 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (313 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (435 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (944 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (430 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1183 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (254 aa)
CD3GCD3g molecule. (182 aa)
LOC104867412C-C motif chemokine. (93 aa)
LOC104865357Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas. (347 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (313 aa)
ENSFDAP00000010317annotation not available (274 aa)
MAPK11Mitogen-activated protein kinase 11. (325 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ENSFDAP00000011016annotation not available (383 aa)
AKT3Non-specific serine/threonine protein kinase. (480 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1197 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
LOC104865308Neuroendocrine secretory protein 55. (229 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1158 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
IFNB1Interferon beta. (187 aa)
FaslgTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (69 aa)
IFNGR2Interferon gamma receptor 2. (319 aa)
C1QCComplement C1q subcomponent subunit C. (303 aa)
FOSProto-oncogene c-Fos. (380 aa)
TGFB1Transforming growth factor beta-1. (333 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
IKBKGNF-kappa-B essential modulator. (417 aa)
MAPK10Mitogen-activated protein kinase. (478 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Pik3r2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
H920_05366Kininogen-1. (224 aa)
TRAV22T cell receptor alpha variable 22. (123 aa)
CALRCalreticulin. (417 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (653 aa)
ACEAngiotensin-converting enzyme. (1218 aa)
ENSFDAP00000018414annotation not available (666 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1149 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (894 aa)
LOC104868943C-C motif chemokine. (93 aa)
GNA14Guanine nucleotide-binding protein subunit alpha-14. (302 aa)
Ppp2caSerine/threonine-protein phosphatase. (275 aa)
TRBV6-4T cell receptor beta variable 6-4. (101 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
TRBV19T cell receptor beta variable 19. (129 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (431 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (462 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha. (744 aa)
AADACArylacetamide deacetylase. (399 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
LOC104863125Toll-like receptor 9. (1029 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
GNALG protein subunit alpha L. (378 aa)
C3Complement C3. (1489 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
H920_02493Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform. (509 aa)
LOC104850622Guanine nucleotide-binding protein G(S) subunit alpha. (394 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (240 aa)
LOC104874367C-C motif chemokine. (119 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
FasTumor necrosis factor receptor superfamily member 6. (290 aa)
C1QBComplement C1q subcomponent subunit B. (250 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1194 aa)
ENSFDAP00000002977annotation not available (131 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha. (355 aa)
TLR2Toll-like receptor 2. (718 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (169 aa)
CCL5C-C motif chemokine. (91 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAPK12Mitogen-activated protein kinase 12. (316 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
CD247T-cell surface glycoprotein CD3 zeta chain. (164 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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