STRINGSTRING
CD40LG CD40LG PECAM1 PECAM1 COMP COMP NID2 NID2 Itgb2 Itgb2 Il18 Il18 TGFB2 TGFB2 ENSFDAP00000002977 ENSFDAP00000002977 TLR2 TLR2 TNF TNF IL12A IL12A LOC104874367 LOC104874367 LRP1B LRP1B CD36 CD36 THBS3 THBS3 MB MB TLR4 TLR4 SELP SELP THBS2 THBS2 KLRK1 KLRK1 NGB NGB IFNG IFNG IL10 IL10 THBS4 THBS4 CLEC12A CLEC12A ITGAL ITGAL SDC2 SDC2 NID1 NID1 TGFB1 TGFB1 HBZ HBZ TRAV22 TRAV22 ICAM1 ICAM1 HGF HGF Il1b Il1b HBQ1 HBQ1 TRBV6-4 TRBV6-4 TRBV19 TRBV19 CD81 CD81 Gypc Gypc LOC104863125 LOC104863125 THBS1 THBS1 ACKR1 ACKR1 TGFB3 TGFB3 LOC104857896 LOC104857896 LOC104857893 LOC104857893 CSF3 CSF3 INCENP INCENP MET MET CYGB CYGB CXCL8 CXCL8 CD40 CD40 SELE SELE LRP1 LRP1 SDC1 SDC1 ENSFDAP00000009051 ENSFDAP00000009051 LOC104857894 LOC104857894 Vcam1 Vcam1 LOC104859809 LOC104859809 MYD88 MYD88
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
PECAM1Platelet endothelial cell adhesion molecule. (740 aa)
COMPCartilage oligomeric matrix protein. (712 aa)
NID2Nidogen 2. (949 aa)
Itgb2Integrin beta. (461 aa)
Il18Interleukin-18. (293 aa)
TGFB2Transforming growth factor beta 2. (398 aa)
ENSFDAP00000002977annotation not available (131 aa)
TLR2Toll-like receptor 2. (718 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (240 aa)
LOC104874367C-C motif chemokine. (119 aa)
LRP1BLow-density lipoprotein receptor-related protein 1B. (4260 aa)
CD36Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
THBS3Thrombospondin-3. (956 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (839 aa)
SELPSelectin P. (768 aa)
THBS2Thrombospondin-2. (1172 aa)
KLRK1NKG2-D type II integral membrane protein. (215 aa)
NGBNeuroglobin; Belongs to the globin family. (151 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
IL10Interleukin-10. (178 aa)
THBS4Thrombospondin-4. (901 aa)
CLEC12AC-type lectin domain family 12 member A. (266 aa)
ITGALIntegrin alpha-L; Belongs to the integrin alpha chain family. (1138 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
NID1Nidogen-1. (1156 aa)
TGFB1Transforming growth factor beta-1. (333 aa)
HBZHemoglobin subunit zeta; Belongs to the globin family. (142 aa)
TRAV22T cell receptor alpha variable 22. (123 aa)
ICAM1Intercellular adhesion molecule 1. (500 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (725 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
HBQ1Hemoglobin subunit theta-1; Belongs to the globin family. (142 aa)
TRBV6-4T cell receptor beta variable 6-4. (101 aa)
TRBV19T cell receptor beta variable 19. (129 aa)
CD81Tetraspanin. (214 aa)
GypcGlycophorin-C. (72 aa)
LOC104863125Toll-like receptor 9. (1029 aa)
THBS1Thrombospondin-1. (1181 aa)
ACKR1Duffy antigen/chemokine receptor. (335 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LOC104857896Hemoglobin subunit epsilon-1; Belongs to the globin family. (147 aa)
LOC104857893Hemoglobin subunit beta; Belongs to the globin family. (147 aa)
CSF3Colony stimulating factor 3. (204 aa)
INCENPInner centromere protein. (750 aa)
METHepatocyte growth factor receptor. (1382 aa)
CYGBCytoglobin; Belongs to the globin family. (163 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (244 aa)
SELEE-selectin. (617 aa)
LRP1Prolow-density lipoprotein receptor-related protein 1. (4419 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (233 aa)
ENSFDAP00000009051annotation not available (385 aa)
LOC104857894Hemoglobin subunit gamma; Belongs to the globin family. (147 aa)
Vcam1Vascular cell adhesion protein 1. (742 aa)
LOC104859809Hemoglobin subunit alpha; Belongs to the globin family. (142 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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