STRINGSTRING
TIRAP TIRAP IL1A IL1A MYD88 MYD88 MRC1 MRC1 LOC104874226 LOC104874226 ATP6V0D1 ATP6V0D1 ENSFDAP00000009051 ENSFDAP00000009051 H920_05759 H920_05759 CLEC4G CLEC4G Casp3 Casp3 H920_04300 H920_04300 Fcgr1a Fcgr1a CALM2 CALM2 PPP1R14B PPP1R14B Ctsd Ctsd LOC104874234 LOC104874234 ENSFDAP00000010317 ENSFDAP00000010317 H920_04309 H920_04309 MAPK11 MAPK11 H920_03480 H920_03480 H920_07367 H920_07367 LOC104872531 LOC104872531 MAPK9 MAPK9 TLR1 TLR1 APAF1 APAF1 AKT3 AKT3 CARD9 CARD9 LOC104861153 LOC104861153 H920_00910 H920_00910 H920_00790 H920_00790 H920_13644 H920_13644 IFNB1 IFNB1 PPP3CA PPP3CA ENSFDAP00000012168 ENSFDAP00000012168 SYK SYK NFYB NFYB EEA1 EEA1 ATP6V0A1 ATP6V0A1 ENSFDAP00000013841 ENSFDAP00000013841 TGFB3 TGFB3 ARHGEF12 ARHGEF12 CASP9 CASP9 LOC104849006 LOC104849006 ENSFDAP00000014417 ENSFDAP00000014417 CEBPG CEBPG CTSS CTSS H920_05677 H920_05677 IL10RA IL10RA RFX5 RFX5 H920_01787 H920_01787 LOC104864952 LOC104864952 NOD2 NOD2 TRAF6 TRAF6 ARSI ARSI H920_17960 H920_17960 Bid Bid C3 C3 H920_10546 H920_10546 CLEC4E CLEC4E SPHK1 SPHK1 LOC104863125 LOC104863125 LOC104849284 LOC104849284 CORO1A CORO1A IL12B IL12B CASP8 CASP8 H920_17965 H920_17965 Rab5a Rab5a EFCAB3 EFCAB3 LAMP2 LAMP2 LOC104857295 LOC104857295 NFYC NFYC HLA-DRA HLA-DRA H920_04312 H920_04312 ENSFDAP00000017399 ENSFDAP00000017399 C7orf31 C7orf31 ENSFDAP00000017469 ENSFDAP00000017469 BCL10 BCL10 NFKB1 NFKB1 IFITM10 IFITM10 JAK2 JAK2 NOS2 NOS2 PPP3R1 PPP3R1 JAK1 JAK1 Il1b Il1b LBP LBP VDR VDR RIPK2 RIPK2 CD14 CD14 MAPK3 MAPK3 LAMP1 LAMP1 ATP6V0C ATP6V0C MAPK1 MAPK1 RAB7A RAB7A MAPK10 MAPK10 RAB5B RAB5B CALM3 CALM3 RFXANK RFXANK PLK3 PLK3 TGFB1 TGFB1 CORO1B CORO1B CAMK2G CAMK2G H920_07716 H920_07716 PLA2R1 PLA2R1 ATP6V0A2 ATP6V0A2 LOC104849283 LOC104849283 ENSFDAP00000021470 ENSFDAP00000021470 H920_17962 H920_17962 Hspd1 Hspd1 IFNGR2 IFNGR2 CALML4 CALML4 LOC104849281 LOC104849281 H920_09835 H920_09835 RHOA RHOA ANKRA2 ANKRA2 CLEC7A CLEC7A FADD FADD ATP6V0D2 ATP6V0D2 CAMK2A CAMK2A ATP6V0A4 ATP6V0A4 IFNG IFNG BAX BAX STAT1 STAT1 ENSFDAP00000000887 ENSFDAP00000000887 H920_13310 H920_13310 IL10 IL10 CORO1C CORO1C ATP6AP1 ATP6AP1 PPP3CC PPP3CC IRAK1 IRAK1 LOC104849321 LOC104849321 IL10RB IL10RB ATP6V1H ATP6V1H MALT1 MALT1 ENSFDAP00000002251 ENSFDAP00000002251 Itgb2 Itgb2 Il18 Il18 MAPK13 MAPK13 CIITA CIITA Cd209 Cd209 RAF1 RAF1 ENSFDAP00000002828 ENSFDAP00000002828 TGFB2 TGFB2 Irak4 Irak4 BPI BPI ENSFDAP00000003237 ENSFDAP00000003237 TLR2 TLR2 TCIRG1 TCIRG1 PIK3C3 PIK3C3 LOC104850724 LOC104850724 H920_16947 H920_16947 AKT1 AKT1 TNF TNF MAPK8 MAPK8 IL12A IL12A CORO6 CORO6 Rhoc Rhoc FCER1G FCER1G TRADD TRADD MAPK14 MAPK14 CREBBP CREBBP Calm1 Calm1 CYP27B1 CYP27B1 BAD BAD Lsp1 Lsp1 H920_06580 H920_06580 HLA-DMA HLA-DMA LOC104850725 LOC104850725 EP300 EP300 IL23A IL23A Camk2d Camk2d ATP6V0B ATP6V0B RELA RELA LOC104873568 LOC104873568 NFYA NFYA PPP3CB PPP3CB KSR1 KSR1 HLA-DOB HLA-DOB TLR4 TLR4 H920_05193 H920_05193 MRC2 MRC2 CAMK2B CAMK2B H920_04301 H920_04301 H920_04299 H920_04299 CREB1 CREB1 H920_13645 H920_13645 SPHK2 SPHK2 HLA-DOA HLA-DOA H920_17964 H920_17964 AKT2 AKT2 Hspa9 Hspa9 Rab5c Rab5c MAPK12 MAPK12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TIRAPToll/interleukin-1 receptor domain-containing adapter protein. (209 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (270 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
MRC1Macrophage mannose receptor 1. (1111 aa)
LOC104874226HLA class II histocompatibility antigen, DQ alpha 1 chain; Belongs to the MHC class II family. (255 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
ENSFDAP00000009051annotation not available (385 aa)
H920_05759DLA class II histocompatibility antigen, DR-1 beta chain. (268 aa)
CLEC4GC-type lectin domain family 4 member G. (293 aa)
Casp3Caspase-3; Belongs to the peptidase C14A family. (277 aa)
H920_04300Ig heavy chain V-III region VH26. (143 aa)
Fcgr1aFc fragment of IgG receptor Ia. (374 aa)
CALM2Calmodulin 2. (149 aa)
PPP1R14BProtein phosphatase 1 regulatory subunit 14B. (122 aa)
CtsdCathepsin D; Belongs to the peptidase A1 family. (410 aa)
LOC104874234H-2 class II histocompatibility antigen, A beta chain. (337 aa)
ENSFDAP00000010317annotation not available (274 aa)
H920_04309Ig heavy chain V region 1B43. (122 aa)
MAPK11Mitogen-activated protein kinase 11. (325 aa)
H920_03480Ig heavy chain V-III region VH26. (176 aa)
H920_07367Ig heavy chain V region M167. (113 aa)
LOC104872531Integrin alpha-M; Belongs to the integrin alpha chain family. (359 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TLR1Toll-like receptor 1; Belongs to the Toll-like receptor family. (808 aa)
APAF1Apoptotic protease-activating factor 1. (1249 aa)
AKT3Non-specific serine/threonine protein kinase. (480 aa)
CARD9Caspase recruitment domain family member 9. (537 aa)
LOC104861153Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
H920_00910V-type proton ATPase 16 kDa proteolipid subunit; Belongs to the V-ATPase proteolipid subunit family. (83 aa)
H920_0079060 kDa heat shock protein, mitochondrial; Belongs to the chaperonin (HSP60) family. (505 aa)
H920_13644Ig heavy chain V region M315. (122 aa)
IFNB1Interferon beta. (187 aa)
PPP3CASerine/threonine-protein phosphatase. (501 aa)
ENSFDAP00000012168annotation not available (120 aa)
SYKTyrosine-protein kinase. (629 aa)
NFYBNuclear transcription factor Y subunit beta. (207 aa)
EEA1Early endosome antigen 1. (1427 aa)
ATP6V0A1V-type proton ATPase 116 kDa subunit a isoform 1. (864 aa)
ENSFDAP00000013841annotation not available (257 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1543 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (406 aa)
LOC104849006HLA class II histocompatibility antigen, DM beta chain. (263 aa)
ENSFDAP00000014417annotation not available (184 aa)
CEBPGCCAAT/enhancer-binding protein gamma. (150 aa)
CTSSGolgi phosphoprotein 3-like; Belongs to the peptidase C1 family. (331 aa)
H920_05677Calcium/calmodulin-dependent protein kinase type II subunit beta. (144 aa)
IL10RAInterleukin-10 receptor subunit alpha. (587 aa)
RFX5DNA-binding protein RFX5. (620 aa)
H920_01787Ig heavy chain V region 441. (173 aa)
LOC104864952Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1097 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
ARSIArylsulfatase I. (575 aa)
H920_17960Ig heavy chain V region 1B43. (137 aa)
BidBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (187 aa)
C3Complement C3. (1489 aa)
H920_10546Ig heavy chain V-III region VH26. (184 aa)
CLEC4EC-type lectin domain family 4 member E. (212 aa)
SPHK1Sphingosine kinase 1. (406 aa)
LOC104863125Toll-like receptor 9. (1029 aa)
LOC104849284CD209 antigen-like protein 2. (239 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (391 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (462 aa)
H920_17965Ig heavy chain V region 1B43. (122 aa)
Rab5aRas-related protein Rab-5A. (215 aa)
EFCAB3EF-hand calcium-binding domain-containing protein 3. (436 aa)
LAMP2Lysosome-associated membrane glycoprotein 2. (411 aa)
LOC104857295Low affinity immunoglobulin gamma Fc region receptor III-B. (260 aa)
NFYCNuclear transcription factor Y subunit gamma. (335 aa)
HLA-DRAMamu class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (254 aa)
H920_04312Ig heavy chain V-III region VH26. (180 aa)
ENSFDAP00000017399annotation not available (622 aa)
C7orf31Uncharacterized protein. (590 aa)
ENSFDAP00000017469annotation not available (306 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (894 aa)
IFITM10Interferon-induced transmembrane protein 10. (130 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1149 aa)
PPP3R1Calcineurin subunit B type 1. (164 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
Il1bMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
LBPLipopolysaccharide binding protein. (494 aa)
VDRVitamin D3 receptor. (419 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2. (482 aa)
CD14Monocyte differentiation antigen CD14. (383 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
LAMP1Lysosome-associated membrane glycoprotein 1. (390 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
RAB7ARas-related protein Rab-7a. (207 aa)
MAPK10Mitogen-activated protein kinase. (478 aa)
RAB5BRas-related protein Rab-5B. (215 aa)
CALM3Calmodulin 3. (148 aa)
RFXANKDNA-binding protein RFXANK. (259 aa)
PLK3Serine/threonine-protein kinase PLK3. (579 aa)
TGFB1Transforming growth factor beta-1. (333 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (486 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (514 aa)
H920_07716DLA class II histocompatibility antigen, DR-1 beta chain. (137 aa)
PLA2R1Secretory phospholipase A2 receptor. (1462 aa)
ATP6V0A2ATPase H+ transporting V0 subunit a2. (855 aa)
LOC104849283CD209 antigen-like protein 2. (212 aa)
ENSFDAP00000021470annotation not available (609 aa)
H920_17962Ig heavy chain V region 1B43. (122 aa)
Hspd160 kDa heat shock protein, mitochondrial; Belongs to the chaperonin (HSP60) family. (573 aa)
IFNGR2Interferon gamma receptor 2. (319 aa)
CALML4Calmodulin like 4. (153 aa)
LOC104849281CD209 antigen-like protein E. (209 aa)
H920_09835Serine/threonine-protein kinase PLK5. (486 aa)
RHOATransforming protein RhoA. (193 aa)
ANKRA2Ankyrin repeat family A protein 2. (313 aa)
CLEC7AC-type lectin domain family 7 member A. (201 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (350 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha. (489 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (833 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
BAXApoptosis regulator BAX. (180 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
ENSFDAP00000000887annotation not available (132 aa)
H920_13310Ig heavy chain V-III region VH26. (180 aa)
IL10Interleukin-10. (178 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
ATP6AP1V-type proton ATPase subunit S1. (459 aa)
PPP3CCSerine/threonine-protein phosphatase. (493 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (453 aa)
LOC104849321CD209 antigen-like protein C. (252 aa)
IL10RBInterleukin-10 receptor subunit beta. (346 aa)
ATP6V1HV-type proton ATPase subunit H. (483 aa)
MALT1Uncharacterized protein. (770 aa)
ENSFDAP00000002251annotation not available (88 aa)
Itgb2Integrin beta. (461 aa)
Il18Interleukin-18. (293 aa)
MAPK13Mitogen-activated protein kinase 13. (323 aa)
CIITAMHC class II transactivator. (1083 aa)
Cd209CD209 molecule. (178 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
ENSFDAP00000002828annotation not available (86 aa)
TGFB2Transforming growth factor beta 2. (398 aa)
Irak4Interleukin-1 receptor-associated kinase 4. (459 aa)
BPIBactericidal permeability increasing protein. (483 aa)
ENSFDAP00000003237annotation not available (159 aa)
TLR2Toll-like receptor 2. (718 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (832 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (892 aa)
LOC104850724C-type lectin domain family 4 member A-like. (244 aa)
H920_16947Ras-related protein Rab-5A. (205 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (240 aa)
CORO6Coronin; Belongs to the WD repeat coronin family. (472 aa)
RhocRas homolog family member C. (193 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (310 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
CREBBPCREB-binding protein. (2426 aa)
Calm1Calmodulin; Belongs to the calmodulin family. (149 aa)
CYP27B125-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (509 aa)
BADBcl2 antagonist of cell death. (162 aa)
Lsp1Lymphocyte-specific protein 1. (82 aa)
H920_06580HLA class II histocompatibility antigen gamma chain. (148 aa)
HLA-DMAHLA class II histocompatibility antigen, DM alpha chain; Belongs to the MHC class II family. (304 aa)
LOC104850725C-type lectin domain family 4 member A. (195 aa)
EP300Histone acetyltransferase p300. (2430 aa)
IL23AInterleukin-23 subunit alpha. (189 aa)
Camk2dCalcium/calmodulin-dependent protein kinase type II subunit delta. (512 aa)
ATP6V0BV-type proton ATPase 21 kDa proteolipid subunit; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
RELATranscription factor p65. (545 aa)
LOC104873568Interferon-induced transmembrane protein 3. (135 aa)
NFYANuclear transcription factor Y subunit alpha. (347 aa)
PPP3CBSerine/threonine-protein phosphatase. (499 aa)
KSR1Kinase suppressor of ras 1. (849 aa)
HLA-DOBHLA class II histocompatibility antigen, DO beta chain. (301 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (839 aa)
H920_05193Integrin alpha-M. (252 aa)
MRC2C-type mannose receptor 2. (1440 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (359 aa)
H920_04301Ig heavy chain V-II region SESS. (170 aa)
H920_04299Ig heavy chain V region 1B43. (122 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (341 aa)
H920_13645Ig heavy chain V region M315. (120 aa)
SPHK2Sphingosine kinase 2. (653 aa)
HLA-DOAHLA class II histocompatibility antigen, DO alpha chain; Belongs to the MHC class II family. (289 aa)
H920_17964Ig heavy chain V region 1B43. (121 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
Hspa9Stress-70 protein, mitochondrial; Belongs to the heat shock protein 70 family. (678 aa)
Rab5cRAB5C, member RAS oncogene family. (216 aa)
MAPK12Mitogen-activated protein kinase 12. (316 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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