STRINGSTRING
EIF2S1 EIF2S1 H920_02493 H920_02493 OAS1 OAS1 PPP2R2B PPP2R2B IFNAR1 IFNAR1 CASP9 CASP9 ENSFDAP00000013841 ENSFDAP00000013841 CLDN25 CLDN25 SOCS3 SOCS3 KRAS KRAS H920_09656 H920_09656 PIK3CD PIK3CD Faslg Faslg LOC104874089 LOC104874089 H920_14855 H920_14855 HRAS HRAS Cldn24 Cldn24 GSK3B GSK3B CLDN14 CLDN14 TP53 TP53 IFNB1 IFNB1 LOC104861153 LOC104861153 PPP2CB PPP2CB IFIT2 IFIT2 AKT3 AKT3 ENSFDAP00000011016 ENSFDAP00000011016 APAF1 APAF1 CLDN9 CLDN9 YWHAE YWHAE RIPK1 RIPK1 EIF2AK3 EIF2AK3 PPP1R14B PPP1R14B CLDN4 CLDN4 Casp3 Casp3 CLDN20 CLDN20 E2F3 E2F3 PPP2R2C PPP2R2C CLDN18 CLDN18 SOS2 SOS2 IRF9 IRF9 CFLAR CFLAR Pik3r3 Pik3r3 RNASEL RNASEL IFIT3 IFIT3 RXRA RXRA LOC104870764 LOC104870764 SOS1 SOS1 PSME3 PSME3 RELA RELA NR1H3 NR1H3 MAP2K1 MAP2K1 H920_03858 H920_03858 BAD BAD CDK6 CDK6 NRAS NRAS YWHAQ YWHAQ AKT2 AKT2 CLDN11 CLDN11 STAT2 STAT2 LOC104848838 LOC104848838 CLDN1 CLDN1 RSAD2 RSAD2 CSDE1 CSDE1 PIK3R1 PIK3R1 IKBKG IKBKG MAPK1 MAPK1 PIK3CA PIK3CA Pik3r2 Pik3r2 TRADD TRADD Fas Fas CLDN19 CLDN19 GRB2 GRB2 TYK2 TYK2 TNF TNF AKT1 AKT1 EIF2AK4 EIF2AK4 EGFR EGFR MAVS MAVS Map2k2 Map2k2 CDK2 CDK2 SCARB1 SCARB1 E2F1 E2F1 ENSFDAP00000002828 ENSFDAP00000002828 RAF1 RAF1 IKBKB IKBKB CDKN1A CDKN1A YWHAB YWHAB IFIT5 IFIT5 CLDN2 CLDN2 ENSFDAP00000002251 ENSFDAP00000002251 Ppp2r1a Ppp2r1a YWHAG YWHAG LOC104854401 LOC104854401 TRAF3 TRAF3 CLDN16 CLDN16 PPP2R2A PPP2R2A PIK3CB PIK3CB E2F2 E2F2 CDK4 CDK4 Ikbke Ikbke BRAF BRAF STAT1 STAT1 CCND1 CCND1 CLDN10 CLDN10 BAX BAX IFNG IFNG TRAF2 TRAF2 EIF3E EIF3E EGF EGF RB1 RB1 EIF2AK1 EIF2AK1 ENSFDAP00000000144 ENSFDAP00000000144 OCLN OCLN MAPK3 MAPK3 Ywhaz Ywhaz Ctnnb1 Ctnnb1 Tlr3 Tlr3 BAK1 BAK1 PPP2R1B PPP2R1B ENSFDAP00000018414 ENSFDAP00000018414 JAK1 JAK1 PIAS1 PIAS1 TBK1 TBK1 NFKB1 NFKB1 PPARA PPARA Eif2ak2 Eif2ak2 IRF3 IRF3 C7orf31 C7orf31 Ppp2ca Ppp2ca STAT3 STAT3 ARAF ARAF FADD FADD CLDN15 CLDN15 PPP2R2D PPP2R2D CASP8 CASP8 Chuk Chuk CD81 CD81 IRF7 IRF7 NFKBIA NFKBIA CLDN17 CLDN17 Bid Bid LDLR LDLR TRAF6 TRAF6 H920_06884 H920_06884 ENSFDAP00000015120 ENSFDAP00000015120 YWHAH YWHAH CXCL10 CXCL10 LOC104855197 LOC104855197 LOC104864952 LOC104864952 CLDN7 CLDN7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
H920_02493Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
OAS12'-5'-oligoadenylate synthase 3. (357 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform. (509 aa)
IFNAR1Interferon alpha/beta receptor 1. (492 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (406 aa)
ENSFDAP00000013841annotation not available (257 aa)
CLDN25Putative claudin-25. (229 aa)
SOCS3Suppressor of cytokine signaling 3. (227 aa)
KRASGTPase HRas. (189 aa)
H920_09656Catenin beta-1. (83 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
FaslgTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (69 aa)
LOC104874089Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
H920_1485514-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (262 aa)
HRASHRas proto-oncogene, GTPase. (191 aa)
Cldn24Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
GSK3BGlycogen synthase kinase 3 beta. (442 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (237 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
IFNB1Interferon beta. (187 aa)
LOC104861153Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
PPP2CBSerine/threonine-protein phosphatase. (275 aa)
IFIT2Interferon-induced protein with tetratricopeptide repeats 2. (447 aa)
AKT3Non-specific serine/threonine protein kinase. (480 aa)
ENSFDAP00000011016annotation not available (383 aa)
APAF1Apoptotic protease-activating factor 1. (1249 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (660 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (1007 aa)
PPP1R14BProtein phosphatase 1 regulatory subunit 14B. (122 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (201 aa)
Casp3Caspase-3; Belongs to the peptidase C14A family. (277 aa)
CLDN20Claudin 20. (219 aa)
E2F3Transcription factor E2F3. (334 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (430 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
SOS2Son of sevenless like protein 2. (1310 aa)
IRF9Interferon regulatory factor 9. (402 aa)
CFLARCASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family. (435 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
RNASEL2-5A-dependent ribonuclease. (628 aa)
IFIT3Interferon-induced protein with tetratricopeptide repeats 3. (403 aa)
RXRARetinoid X receptor alpha. (464 aa)
LOC104870764Interferon-induced GTP-binding protein Mx2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (654 aa)
SOS1Son of sevenless like protein 1. (1289 aa)
PSME3Proteasome activator complex subunit 3. (265 aa)
RELATranscription factor p65. (545 aa)
NR1H3Oxysterols receptor LXR-alpha. (443 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (388 aa)
H920_03858Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (161 aa)
BADBcl2 antagonist of cell death. (162 aa)
CDK6Cyclin-dependent kinase 6. (296 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
YWHAQ14-3-3 protein theta; Belongs to the 14-3-3 family. (304 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
STAT2Signal transducer and activator of transcription. (834 aa)
LOC104848838Interferon-induced protein with tetratricopeptide repeats 1B. (477 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
RSAD2Radical S-adenosyl methionine domain-containing protein 2. (351 aa)
CSDE1Cold shock domain-containing protein E1. (798 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
IKBKGNF-kappa-B essential modulator. (417 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Pik3r2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (310 aa)
FasTumor necrosis factor receptor superfamily member 6. (290 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
TYK2Tyrosine-protein kinase. (981 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1661 aa)
EGFRReceptor protein-tyrosine kinase. (1168 aa)
MAVSMitochondrial antiviral-signaling protein. (507 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (370 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (502 aa)
E2F1Transcription factor E2F1. (377 aa)
ENSFDAP00000002828annotation not available (86 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (165 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (246 aa)
IFIT5Interferon-induced protein with tetratricopeptide repeats 5. (482 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
ENSFDAP00000002251annotation not available (88 aa)
Ppp2r1aSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (573 aa)
YWHAG14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa)
LOC104854401Probable ATP-dependent RNA helicase DDX58. (520 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (272 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform. (458 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
E2F2Transcription factor E2F2. (391 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
IkbkeInhibitor of nuclear factor kappa-B kinase subunit epsilon. (130 aa)
BRAFSerine/threonine-protein kinase B-raf. (740 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
CLDN10Claudin 10. (231 aa)
BAXApoptosis regulator BAX. (180 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (445 aa)
EGFPro-epidermal growth factor. (1155 aa)
RB1Retinoblastoma-associated protein. (882 aa)
EIF2AK1Eukaryotic translation initiation factor 2-alpha kinase 1. (580 aa)
ENSFDAP00000000144annotation not available (263 aa)
OCLNOccludin. (523 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
Ywhaz14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (245 aa)
Ctnnb1Catenin beta-1. (781 aa)
Tlr3Toll like receptor 3. (92 aa)
BAK1Bcl-2 like proteinous antagonist/killer. (212 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (653 aa)
ENSFDAP00000018414annotation not available (666 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
PIAS1E3 SUMO-protein ligase PIAS1. (647 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (894 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
Eif2ak2Interferon-induced, double-stranded RNA-activated protein kinase. (448 aa)
IRF3Interferon regulatory factor 3. (428 aa)
C7orf31Uncharacterized protein. (590 aa)
Ppp2caSerine/threonine-protein phosphatase. (275 aa)
STAT3Signal transducer and activator of transcription. (758 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (431 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (462 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha. (744 aa)
CD81Tetraspanin. (214 aa)
IRF7Interferon regulatory factor 7. (430 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
CLDN17Claudin 17. (224 aa)
BidBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (187 aa)
LDLRLow-density lipoprotein receptor. (779 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (543 aa)
H920_0688414-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (245 aa)
ENSFDAP00000015120annotation not available (546 aa)
YWHAH14-3-3 protein eta; Belongs to the 14-3-3 family. (217 aa)
CXCL10C-X-C motif chemokine. (95 aa)
LOC10485519714-3-3 protein eta; Belongs to the 14-3-3 family. (246 aa)
LOC104864952Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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