STRINGSTRING
Calm1 Calm1 MAPKAPK2 MAPKAPK2 AKT1 AKT1 PIK3R5 PIK3R5 ATG14 ATG14 Becn1 Becn1 PTGS2 PTGS2 Gng14 Gng14 PIK3C3 PIK3C3 GNGT1 GNGT1 Map2k2 Map2k2 ENSFDAP00000002920 ENSFDAP00000002920 E2F1 E2F1 ENSFDAP00000002828 ENSFDAP00000002828 RAF1 RAF1 H920_13524 H920_13524 CD69 CD69 IKBKB IKBKB MAPK13 MAPK13 CDKN1A CDKN1A ENSFDAP00000002251 ENSFDAP00000002251 ENSFDAP00000002122 ENSFDAP00000002122 TRAF3 TRAF3 CD86 CD86 TYK2 TYK2 GABARAP GABARAP ITPR1 ITPR1 GNB3 GNB3 RAC1 RAC1 Fas Fas TRADD TRADD MAPK14 MAPK14 CREBBP CREBBP ENSFDAP00000004169 ENSFDAP00000004169 MAPK8 MAPK8 Fgf2 Fgf2 FADD FADD LOC104852000 LOC104852000 RB1 RB1 TRAF2 TRAF2 BAX BAX CCND1 CCND1 STAT1 STAT1 ENSFDAP00000000887 ENSFDAP00000000887 LOC104873772 LOC104873772 Map2k4 Map2k4 H920_17227 H920_17227 Ikbke Ikbke CDK4 CDK4 E2F2 E2F2 PIK3CB PIK3CB ATG3 ATG3 LOC104875717 LOC104875717 PPP3CC PPP3CC MAPK12 MAPK12 GNG3 GNG3 PDGFB PDGFB CDK6 CDK6 NRAS NRAS AKT2 AKT2 GNG11 GNG11 STAT2 STAT2 GABARAPL2 GABARAPL2 HIF1A HIF1A UBA52 UBA52 CALML4 CALML4 LYN LYN CSDE1 CSDE1 FOS FOS PIK3R1 PIK3R1 CALM3 CALM3 GNG2 GNG2 IKBKG IKBKG MAPK10 MAPK10 PLCG1 PLCG1 MAPK1 MAPK1 PIK3CA PIK3CA ZFP36 ZFP36 Pik3r2 Pik3r2 NFATC3 NFATC3 GNG4 GNG4 MAPK3 MAPK3 GNB1 GNB1 Ctnnb1 Ctnnb1 Tlr3 Tlr3 ICAM1 ICAM1 BAK1 BAK1 ENSFDAP00000018414 ENSFDAP00000018414 Ubc Ubc JAK1 JAK1 CSF2 CSF2 PPP3R1 PPP3R1 H920_17537 H920_17537 JAK2 JAK2 TBK1 TBK1 NFKB1 NFKB1 GABARAPL1 GABARAPL1 Eif2ak2 Eif2ak2 ITPR2 ITPR2 PREX1 PREX1 IRF3 IRF3 C7orf31 C7orf31 STAT3 STAT3 MAP2K7 MAP2K7 PIK3R6 PIK3R6 CASP8 CASP8 Chuk Chuk MTOR MTOR IRF7 IRF7 IL6ST IL6ST GNG13 GNG13 ENSFDAP00000016221 ENSFDAP00000016221 NFKBIA NFKBIA C3 C3 Bid Bid ANGPT2 ANGPT2 Vegfa Vegfa PREX2 PREX2 LOC104864952 LOC104864952 GNG7 GNG7 GNB4 GNB4 TCF7L1 TCF7L1 IFNAR1 IFNAR1 RPS27A RPS27A CASP9 CASP9 ENSFDAP00000013841 ENSFDAP00000013841 GNG8 GNG8 KRAS KRAS CCR4 CCR4 H920_09656 H920_09656 PIK3CD PIK3CD SYK SYK LOC104861058 LOC104861058 HRAS HRAS LEF1 LEF1 GSK3B GSK3B H920_05446 H920_05446 PPP3CA PPP3CA TP53 TP53 H920_05447 H920_05447 IFNB1 IFNB1 CXCL8 CXCL8 LOC104861153 LOC104861153 CCR1 CCR1 AKT3 AKT3 ITPR3 ITPR3 H920_01844 H920_01844 MAPK9 MAPK9 Ccr5 Ccr5 CCR8 CCR8 GNB5 GNB5 MAPK11 MAPK11 ENSFDAP00000010317 ENSFDAP00000010317 RCAN1 RCAN1 PIK3CG PIK3CG NFATC2 NFATC2 CALM2 CALM2 NFATC4 NFATC4 Casp3 Casp3 JUN JUN E2F3 E2F3 TCF7L2 TCF7L2 IRF9 IRF9 Pik3r3 Pik3r3 CREB1 CREB1 TCF7 TCF7 MAP2K6 MAP2K6 GNB2 GNB2 PPP3CB PPP3CB RELA RELA NFATC1 NFATC1 MAP2K1 MAP2K1 EP300 EP300
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Calm1Calmodulin; Belongs to the calmodulin family. (149 aa)
MAPKAPK2MAP kinase-activated protein kinase 2. (399 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 6. (874 aa)
ATG14Beclin 1-associated autophagy-related key regulator. (492 aa)
Becn1Beclin-1. (448 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (601 aa)
Gng14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (892 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (370 aa)
ENSFDAP00000002920annotation not available (87 aa)
E2F1Transcription factor E2F1. (377 aa)
ENSFDAP00000002828annotation not available (86 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
H920_13524RLA class I histocompatibility antigen, alpha chain 11/11. (331 aa)
CD69Early activation antigen CD69-like. (199 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
MAPK13Mitogen-activated protein kinase 13. (323 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (165 aa)
ENSFDAP00000002251annotation not available (88 aa)
ENSFDAP00000002122annotation not available (80 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
CD86T-lymphocyte activation antigen CD86. (317 aa)
TYK2Tyrosine-protein kinase. (981 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2758 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (199 aa)
FasTumor necrosis factor receptor superfamily member 6. (290 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (310 aa)
MAPK14Mitogen-activated protein kinase. (321 aa)
CREBBPCREB-binding protein. (2426 aa)
ENSFDAP00000004169annotation not available (234 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
Fgf2Fibroblast growth factor 2. (129 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
LOC1048520001-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1255 aa)
RB1Retinoblastoma-associated protein. (882 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
BAXApoptosis regulator BAX. (180 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
ENSFDAP00000000887annotation not available (132 aa)
LOC104873772C-X-C motif chemokine. (134 aa)
Map2k4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (381 aa)
H920_17227Beclin-1. (445 aa)
IkbkeInhibitor of nuclear factor kappa-B kinase subunit epsilon. (130 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
E2F2Transcription factor E2F2. (391 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
ATG3Autophagy-related protein 3. (313 aa)
LOC104875717Patr class I histocompatibility antigen, A-126 alpha chain; Belongs to the MHC class I family. (551 aa)
PPP3CCSerine/threonine-protein phosphatase. (493 aa)
MAPK12Mitogen-activated protein kinase 12. (316 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (229 aa)
CDK6Cyclin-dependent kinase 6. (296 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
STAT2Signal transducer and activator of transcription. (834 aa)
GABARAPL2Gamma-aminobutyric acid receptor-associated protein-like 2. (117 aa)
HIF1AHypoxia-inducible factor 1-alpha. (815 aa)
UBA52KxDL motif containing 1. (232 aa)
CALML4Calmodulin like 4. (153 aa)
LYNTyrosine-protein kinase. (512 aa)
CSDE1Cold shock domain-containing protein E1. (798 aa)
FOSProto-oncogene c-Fos. (380 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
CALM3Calmodulin 3. (148 aa)
GNG2G protein subunit gamma 2. (71 aa)
IKBKGNF-kappa-B essential modulator. (417 aa)
MAPK10Mitogen-activated protein kinase. (478 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ZFP36Tristetraprolin. (315 aa)
Pik3r2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (1043 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (340 aa)
Ctnnb1Catenin beta-1. (781 aa)
Tlr3Toll like receptor 3. (92 aa)
ICAM1Intercellular adhesion molecule 1. (500 aa)
BAK1Bcl-2 like proteinous antagonist/killer. (212 aa)
ENSFDAP00000018414annotation not available (666 aa)
UbcPolyubiquitin-B. (235 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
CSF2Uncharacterized protein. (144 aa)
PPP3R1Calcineurin subunit B type 1. (164 aa)
H920_17537Patr class I histocompatibility antigen, A-126 alpha chain; Belongs to the MHC class I family. (459 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (894 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1. (113 aa)
Eif2ak2Interferon-induced, double-stranded RNA-activated protein kinase. (448 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
PREX1Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein. (1577 aa)
IRF3Interferon regulatory factor 3. (428 aa)
C7orf31Uncharacterized protein. (590 aa)
STAT3Signal transducer and activator of transcription. (758 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7. (427 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (738 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (462 aa)
ChukInhibitor of nuclear factor kappa-B kinase subunit alpha. (744 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2551 aa)
IRF7Interferon regulatory factor 7. (430 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
ENSFDAP00000016221annotation not available (41 aa)
NFKBIANF-kappa-B inhibitor alpha. (224 aa)
C3Complement C3. (1489 aa)
BidBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (187 aa)
ANGPT2Angiopoietin 2. (494 aa)
VegfaVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (186 aa)
PREX2Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein. (1559 aa)
LOC104864952Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
GNG7G protein subunit gamma 7. (69 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
TCF7L1Transcription factor 7-like 1. (453 aa)
IFNAR1Interferon alpha/beta receptor 1. (492 aa)
RPS27AUbiquitin-40S ribosomal protein S27a. (156 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (406 aa)
ENSFDAP00000013841annotation not available (257 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
KRASGTPase HRas. (189 aa)
CCR4C-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
H920_09656Catenin beta-1. (83 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
SYKTyrosine-protein kinase. (629 aa)
LOC104861058Ubiquitin-like. (77 aa)
HRASHRas proto-oncogene, GTPase. (191 aa)
LEF1Lymphoid enhancer-binding factor 1. (329 aa)
GSK3BGlycogen synthase kinase 3 beta. (442 aa)
H920_05446Putative C-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (288 aa)
PPP3CASerine/threonine-protein phosphatase. (501 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
H920_05447C-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (140 aa)
IFNB1Interferon beta. (187 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
LOC104861153Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
CCR1C-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
AKT3Non-specific serine/threonine protein kinase. (480 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2524 aa)
H920_01844Polyubiquitin-B. (77 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
Ccr5C-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (353 aa)
CCR8C-C chemokine receptor type 8; Belongs to the G-protein coupled receptor 1 family. (355 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (354 aa)
MAPK11Mitogen-activated protein kinase 11. (325 aa)
ENSFDAP00000010317annotation not available (274 aa)
RCAN1Calcipressin-1. (197 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1095 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2. (850 aa)
CALM2Calmodulin 2. (149 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4. (868 aa)
Casp3Caspase-3; Belongs to the peptidase C14A family. (277 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (254 aa)
E2F3Transcription factor E2F3. (334 aa)
TCF7L2Transcription factor 7 like 2. (413 aa)
IRF9Interferon regulatory factor 9. (402 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (341 aa)
TCF7Transcription factor 7. (302 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (335 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
PPP3CBSerine/threonine-protein phosphatase. (499 aa)
RELATranscription factor p65. (545 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (783 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (388 aa)
EP300Histone acetyltransferase p300. (2430 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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