STRINGSTRING
Kmt2a Kmt2a MLLT1 MLLT1 ENSFDAP00000004786 ENSFDAP00000004786 JUP JUP ETV4 ETV4 ELANE ELANE SMAD1 SMAD1 PDGFA PDGFA NGFR NGFR IGF1R IGF1R KDM6A KDM6A NR4A3 NR4A3 ITGB7 ITGB7 GRIA3 GRIA3 LOC104854599 LOC104854599 MAF MAF RELA RELA MMP10 MMP10 FEV FEV ETV5 ETV5 IL1R2 IL1R2 RXRB RXRB ERG ERG ENSFDAP00000006488 ENSFDAP00000006488 SUPT3H SUPT3H DOT1L DOT1L H920_05193 H920_05193 RXRA RXRA MEIS2 MEIS2 NTRK1 NTRK1 LOC109118287 LOC109118287 H920_04301 H920_04301 H920_04299 H920_04299 Igfbp3 Igfbp3 H920_13645 H920_13645 SS18 SS18 PBX2 PBX2 IL2RB IL2RB MLF1 MLF1 LOC109117804 LOC109117804 SP1 SP1 CSF1R CSF1R LOC104858299 LOC104858299 JMJD1C JMJD1C ENSFDAP00000009586 ENSFDAP00000009586 H920_04300 H920_04300 Fcgr1a Fcgr1a MPO MPO MITF MITF NFKBIZ NFKBIZ PBX1 PBX1 H920_04309 H920_04309 CD40 CD40 H920_03480 H920_03480 H920_07367 H920_07367 LOC104872531 LOC104872531 LOC104875780 LOC104875780 FUT8 FUT8 HOXC11 HOXC11 LOC104861512 LOC104861512 PAX5 PAX5 PRCC PRCC ENSFDAP00000010877 ENSFDAP00000010877 H920_04845 H920_04845 PML PML AFF1 AFF1 H920_13644 H920_13644 ETV6 ETV6 PLAT PLAT SIN3B SIN3B CXCL8 CXCL8 ENSFDAP00000011505 ENSFDAP00000011505 MLLT3 MLLT3 TP53 TP53 ETV1 ETV1 ENSFDAP00000011804 ENSFDAP00000011804 Ddx5 Ddx5 MET MET ELK4 ELK4 PAX3 PAX3 WT1 WT1 ENSFDAP00000012168 ENSFDAP00000012168 HDAC2 HDAC2 TFE3 TFE3 CEBPE CEBPE CDK9 CDK9 ATM ATM MMP3 MMP3 FOXO1 FOXO1 CDKN2C CDKN2C CCNT2 CCNT2 Hoxa10 Hoxa10 SLC45A3 SLC45A3 LOC104870597 LOC104870597 TLX3 TLX3 FLI1 FLI1 H920_02950 H920_02950 LOC104872504 LOC104872504 ENSFDAP00000014417 ENSFDAP00000014417 H920_01787 H920_01787 PAX2 PAX2 Bmi1 Bmi1 GZMH GZMH ZEB1 ZEB1 TMPRSS2 TMPRSS2 BAIAP3 BAIAP3 H920_19890 H920_19890 CCNA2 CCNA2 FLT3 FLT3 H920_17960 H920_17960 PER2 PER2 H920_10546 H920_10546 EWSR1 EWSR1 LOC104861341 LOC104861341 LOC104866854 LOC104866854 SIX2 SIX2 LOC104864167 LOC104864167 PPARG PPARG SIX1 SIX1 ENSFDAP00000016469 ENSFDAP00000016469 H920_17965 H920_17965 TRBV19 TRBV19 BCL2L1 BCL2L1 CCNA1 CCNA1 LMO2 LMO2 H920_04312 H920_04312 TRBV6-4 TRBV6-4 SPINT1 SPINT1 DDB2 DDB2 NFKB1 NFKB1 REL REL PTK2 PTK2 Tlx1 Tlx1 LOC104864184 LOC104864184 CSF2 CSF2 RXRG RXRG MEN1 MEN1 BAK1 BAK1 PBX3 PBX3 KLF3 KLF3 TRAV22 TRAV22 CD14 CD14 MEF2C MEF2C DDIT3 DDIT3 TAF15 TAF15 PLAU PLAU HDAC1 HDAC1 ARNT2 ARNT2 Hhex Hhex MMP9 MMP9 PAX7 PAX7 H920_17964 H920_17964 LOC104870596-2 LOC104870596-2 TRAF1 TRAF1 GADD45G GADD45G ENSFDAP00000022738 ENSFDAP00000022738 BIRC2 BIRC2 TSPAN7 TSPAN7 ENSFDAP00000022310 ENSFDAP00000022310 RUNX2 RUNX2 Runx1t1 Runx1t1 H920_17962 H920_17962 FUS FUS ATF1 ATF1 NCOR1 NCOR1 CDKN1B CDKN1B LOC104867440 LOC104867440 HOXA11 HOXA11 H920_04861 H920_04861 BCL6 BCL6 ENSFDAP00000021231 ENSFDAP00000021231 H920_12339 H920_12339 Mdm2 Mdm2 PROM1 PROM1 ZBTB16 ZBTB16 ENSFDAP00000020975 ENSFDAP00000020975 ZBTB17 ZBTB17 FLT1 FLT1 BMP2K BMP2K DUSP6 DUSP6 H920_14430 H920_14430 Hoxa9 Hoxa9 IGF1 IGF1 ENSFDAP00000000261 ENSFDAP00000000261 POLK POLK BCL2A1 BCL2A1 BAX BAX H920_13310 H920_13310 PAX8 PAX8 WNT16 WNT16 EYA1 EYA1 CD86 CD86 NSD2 NSD2 H920_09861 H920_09861 SIN3A SIN3A CDK14 CDK14 CDKN1A CDKN1A RARA RARA TGFBR2 TGFBR2 ENSFDAP00000002977 ENSFDAP00000002977 H920_16725 H920_16725 MEIS1 MEIS1 H920_14510 H920_14510 HPGD HPGD Ccnd2 Ccnd2 CCNT1 CCNT1 LDB1 LDB1 LYL1 LYL1 BIRC3 BIRC3 LOC104864185 LOC104864185 TCF3 TCF3 SIX4 SIX4 SPI1 SPI1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Kmt2aHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3838 aa)
MLLT1Protein ENL. (552 aa)
ENSFDAP00000004786annotation not available (71 aa)
JUPJunction plakoglobin. (588 aa)
ETV4ETS domain-containing protein. (437 aa)
ELANEElastase, neutrophil expressed. (189 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (207 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (362 aa)
IGF1RInsulin like growth factor 1 receptor. (1107 aa)
KDM6ALysine-specific demethylase 6A. (1370 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (604 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (736 aa)
GRIA3Glutamate receptor 3. (894 aa)
LOC104854599Histone H3; Belongs to the histone H3 family. (136 aa)
MAFTranscription factor MafA; Belongs to the bZIP family. (221 aa)
RELATranscription factor p65. (545 aa)
MMP10Stromelysin-2. (478 aa)
FEVProtein FEV. (178 aa)
ETV5ETS domain-containing protein. (510 aa)
IL1R2Interleukin-1 receptor type 2. (422 aa)
RXRBRetinoic acid receptor RXR-beta. (486 aa)
ERGTranscriptional regulator ERG. (486 aa)
ENSFDAP00000006488annotation not available (127 aa)
SUPT3HTranscription initiation protein SPT3 like protein. (374 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1514 aa)
H920_05193Integrin alpha-M. (252 aa)
RXRARetinoid X receptor alpha. (464 aa)
MEIS2Homeobox protein Meis2. (474 aa)
NTRK1Tyrosine-protein kinase receptor. (727 aa)
LOC109118287Neutrophil antibiotic peptide NP-3A-like. (84 aa)
H920_04301Ig heavy chain V-II region SESS. (170 aa)
H920_04299Ig heavy chain V region 1B43. (122 aa)
Igfbp3Insulin-like growth factor-binding protein 3. (170 aa)
H920_13645Ig heavy chain V region M315. (120 aa)
SS18Protein SSXT. (395 aa)
PBX2Pre-B-cell leukemia transcription factor 2. (423 aa)
IL2RBInterleukin-2 receptor subunit beta. (528 aa)
MLF1Myeloid leukemia factor 1. (270 aa)
LOC109117804Histone H3, embryonic-like. (76 aa)
SP1Transcription factor Sp1. (784 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (988 aa)
LOC104858299Histone H3.3. (136 aa)
JMJD1CPutative JmjC domain-containing histone demethylation protein 2C. (2538 aa)
ENSFDAP00000009586annotation not available (571 aa)
H920_04300Ig heavy chain V-III region VH26. (143 aa)
Fcgr1aFc fragment of IgG receptor Ia. (374 aa)
MPOMyeloperoxidase. (718 aa)
MITFMicrophthalmia-associated transcription factor. (510 aa)
NFKBIZNF-kappa-B inhibitor zeta. (630 aa)
PBX1Pre-B-cell leukemia transcription factor 1. (391 aa)
H920_04309Ig heavy chain V region 1B43. (122 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (244 aa)
H920_03480Ig heavy chain V-III region VH26. (176 aa)
H920_07367Ig heavy chain V region M167. (113 aa)
LOC104872531Integrin alpha-M; Belongs to the integrin alpha chain family. (359 aa)
LOC104875780Histone H3.3. (124 aa)
FUT8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (575 aa)
HOXC11Homeobox C11. (251 aa)
LOC104861512Histone H3; Belongs to the histone H3 family. (136 aa)
PAX5Paired box protein Pax-5. (391 aa)
PRCCProline-rich protein PRCC. (477 aa)
ENSFDAP00000010877annotation not available (140 aa)
H920_04845Histone H3.3 type 2. (102 aa)
PMLProtein PML. (634 aa)
AFF1AF4/FMR2 family member 1. (1194 aa)
H920_13644Ig heavy chain V region M315. (122 aa)
ETV6Transcription factor ETV6. (468 aa)
PLATTissue-type plasminogen activator. (602 aa)
SIN3BPaired amphipathic helix protein Sin3b. (992 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
ENSFDAP00000011505annotation not available (67 aa)
MLLT3Protein AF-9. (568 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ETV1ETS domain-containing protein. (472 aa)
ENSFDAP00000011804annotation not available (202 aa)
Ddx5Putative ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (600 aa)
METHepatocyte growth factor receptor. (1382 aa)
ELK4ETS domain-containing protein Elk-4. (428 aa)
PAX3Paired box protein Pax-3. (484 aa)
WT1Wilms tumor protein. (302 aa)
ENSFDAP00000012168annotation not available (120 aa)
HDAC2Histone deacetylase 2. (484 aa)
TFE3Transcription factor E3. (539 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
CDK9Cyclin dependent kinase 9. (378 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa)
MMP3Stromelysin-1. (476 aa)
FOXO1Forkhead box protein O1. (522 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
CCNT2Cyclin-T2; Belongs to the cyclin family. (733 aa)
Hoxa10Homeobox A10. (94 aa)
SLC45A3Solute carrier family 45 member 3. (520 aa)
LOC104870597Histone H3; Belongs to the histone H3 family. (136 aa)
TLX3T-cell leukemia homeobox protein 3. (252 aa)
FLI1Friend leukemia integration 1 transcription factor. (452 aa)
H920_02950Tether containing UBX domain for GLUT4. (135 aa)
LOC104872504Histone H3.3. (136 aa)
ENSFDAP00000014417annotation not available (184 aa)
H920_01787Ig heavy chain V region 441. (173 aa)
PAX2Paired box protein Pax-2. (359 aa)
Bmi1Polycomb complex protein BMI-1. (326 aa)
GZMHGranzyme H; Belongs to the peptidase S1 family. (245 aa)
ZEB1Zinc finger E-box-binding homeobox 1. (1110 aa)
TMPRSS2Interferon-induced GTP-binding protein Mx2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (427 aa)
BAIAP3BAI1-associated protein 3. (1152 aa)
H920_19890Histone H3.3 type 2. (158 aa)
CCNA2Cyclin A2. (400 aa)
FLT3FL cytokine receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (973 aa)
H920_17960Ig heavy chain V region 1B43. (137 aa)
PER2Period circadian protein like protein 2. (1226 aa)
H920_10546Ig heavy chain V-III region VH26. (184 aa)
EWSR1RNA-binding protein EWS. (655 aa)
LOC104861341Histone H3. (136 aa)
LOC104866854Lysine-specific demethylase 6A-like. (588 aa)
SIX2Homeobox protein SIX2. (295 aa)
LOC104864167Granzyme B; Belongs to the peptidase S1 family. (247 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
SIX1Homeobox protein SIX1. (284 aa)
ENSFDAP00000016469annotation not available (353 aa)
H920_17965Ig heavy chain V region 1B43. (122 aa)
TRBV19T cell receptor beta variable 19. (129 aa)
BCL2L1Bcl-2-like protein 1. (233 aa)
CCNA1Cyclin-A1; Belongs to the cyclin family. (421 aa)
LMO2Rhombotin-2. (144 aa)
H920_04312Ig heavy chain V-III region VH26. (180 aa)
TRBV6-4T cell receptor beta variable 6-4. (101 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (509 aa)
DDB2DNA damage-binding protein 2. (296 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (894 aa)
RELProto-oncogene c-Rel. (582 aa)
PTK2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1083 aa)
Tlx1T-cell leukemia homeobox protein 1. (91 aa)
LOC104864184Granzyme B(G,H); Belongs to the peptidase S1 family. (235 aa)
CSF2Uncharacterized protein. (144 aa)
RXRGRetinoic acid receptor RXR-gamma. (463 aa)
MEN1Menin. (616 aa)
BAK1Bcl-2 like proteinous antagonist/killer. (212 aa)
PBX3Pre-B-cell leukemia transcription factor 3. (367 aa)
KLF3Krueppel-like factor 3. (344 aa)
TRAV22T cell receptor alpha variable 22. (123 aa)
CD14Monocyte differentiation antigen CD14. (383 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
DDIT3DNA damage-inducible transcript 3 protein. (167 aa)
TAF15TATA-binding protein-associated factor 2N. (553 aa)
PLAUUrokinase-type plasminogen activator. (434 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
ARNT2Uncharacterized protein. (702 aa)
HhexHematopoietically-expressed homeobox protein HHEX. (98 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
PAX7Paired box protein Pax-7. (498 aa)
H920_17964Ig heavy chain V region 1B43. (121 aa)
LOC104870596-2Histone H3. (136 aa)
TRAF1TNF receptor-associated factor. (415 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
ENSFDAP00000022738annotation not available (124 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (618 aa)
TSPAN7Tetraspanin. (247 aa)
ENSFDAP00000022310annotation not available (86 aa)
RUNX2Runt-related transcription factor 2. (508 aa)
Runx1t1Protein CBFA2T1. (604 aa)
H920_17962Ig heavy chain V region 1B43. (122 aa)
FUSRNA-binding protein FUS. (516 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1. (309 aa)
NCOR1Nuclear receptor corepressor 1. (2434 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
LOC104867440Defensin-7. (87 aa)
HOXA11Homeobox protein Hox-D11. (314 aa)
H920_04861Histone H3. (140 aa)
BCL6B-cell lymphoma 6 protein. (688 aa)
ENSFDAP00000021231annotation not available (304 aa)
H920_12339Myosin-binding protein C, fast-type. (158 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2. (504 aa)
PROM1Prominin-1. (897 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16. (676 aa)
ENSFDAP00000020975annotation not available (69 aa)
ZBTB17Zinc finger and BTB domain-containing protein 17. (459 aa)
FLT1Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1311 aa)
BMP2KBMP-2-inducible protein kinase. (1074 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
H920_14430Histone H3.3. (187 aa)
Hoxa9Homeobox A9. (243 aa)
IGF1Insulin-like growth factor I. (158 aa)
ENSFDAP00000000261annotation not available (93 aa)
POLKDNA polymerase kappa. (862 aa)
BCL2A15-formyltetrahydrofolate cyclo-ligase. (171 aa)
BAXApoptosis regulator BAX. (180 aa)
H920_13310Ig heavy chain V-III region VH26. (180 aa)
PAX8Paired box protein Pax-8. (459 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (591 aa)
CD86T-lymphocyte activation antigen CD86. (317 aa)
NSD2Putative histone-lysine N-methyltransferase NSD2. (1366 aa)
H920_09861Myeloblastin. (154 aa)
SIN3APaired amphipathic helix protein Sin3a. (1274 aa)
CDK14Cyclin dependent kinase 14. (451 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (165 aa)
RARARetinoic acid receptor alpha. (421 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (560 aa)
ENSFDAP00000002977annotation not available (131 aa)
H920_16725Histone H3.3 type 2. (201 aa)
MEIS1Homeobox protein Meis2. (465 aa)
H920_14510Protein max. (163 aa)
HPGD15-hydroxyprostaglandin dehydrogenase [NAD+]; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
Ccnd2G1/S-specific cyclin-D2; Belongs to the cyclin family. (288 aa)
CCNT1Cyclin-T1; Belongs to the cyclin family. (727 aa)
LDB1LIM domain-binding protein 1. (408 aa)
LYL1Protein lyl-1. (244 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (644 aa)
LOC104864185Granzyme-like protein 1; Belongs to the peptidase S1 family. (254 aa)
TCF3Transcription factor E2-alpha. (636 aa)
SIX4Homeobox protein SIX4. (592 aa)
SPI1Spi-1 proto-oncogene. (263 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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