STRINGSTRING
ERBB2 ERBB2 NRAS NRAS AKT2 AKT2 GADD45G GADD45G AXIN1 AXIN1 Foxo3 Foxo3 CSDE1 CSDE1 PIK3R1 PIK3R1 MAPK1 MAPK1 PIK3CA PIK3CA Pik3r2 Pik3r2 MAPK3 MAPK3 Ctnnb1 Ctnnb1 BAK1 BAK1 CTNNA2 CTNNA2 DDB2 DDB2 ARAF ARAF CDH1 CDH1 PTEN PTEN LOC104870857 LOC104870857 MLH1 MLH1 TCF7L1 TCF7L1 CASP9 CASP9 ILK ILK KRAS KRAS H920_09656 H920_09656 AXIN2 AXIN2 PIK3CD PIK3CD HRAS HRAS LEF1 LEF1 GSK3B GSK3B CTNNA3 CTNNA3 TP53 TP53 AKT3 AKT3 ELK1 ELK1 PPP1R14B PPP1R14B TCF7L2 TCF7L2 SOS2 SOS2 Pik3r3 Pik3r3 TCF7 TCF7 SOS1 SOS1 MAP2K1 MAP2K1 BAD BAD GRB2 GRB2 AKT1 AKT1 EGFR EGFR PDPK1 PDPK1 APC2 APC2 Map2k2 Map2k2 RAF1 RAF1 APC APC CDKN1A CDKN1A CTNNA1 CTNNA1 PIK3CB PIK3CB BRAF BRAF CCND1 CCND1 BAX BAX EGF EGF POLK POLK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERBB2Receptor protein-tyrosine kinase. (1212 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
AXIN1Axin-1. (865 aa)
Foxo3Forkhead box protein O3. (674 aa)
CSDE1Cold shock domain-containing protein E1. (798 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha. (730 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
Pik3r2Phosphoinositide-3-kinase regulatory subunit 2. (71 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
Ctnnb1Catenin beta-1. (781 aa)
BAK1Bcl-2 like proteinous antagonist/killer. (212 aa)
CTNNA2Catenin alpha-2. (954 aa)
DDB2DNA damage-binding protein 2. (296 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (895 aa)
PTENPhosphatase and tensin homolog. (403 aa)
LOC104870857Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like. (486 aa)
MLH1DNA mismatch repair protein Mlh1. (767 aa)
TCF7L1Transcription factor 7-like 1. (453 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (406 aa)
ILKIntegrin-linked protein kinase. (452 aa)
KRASGTPase HRas. (189 aa)
H920_09656Catenin beta-1. (83 aa)
AXIN2Axin-2. (860 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
HRASHRas proto-oncogene, GTPase. (191 aa)
LEF1Lymphoid enhancer-binding factor 1. (329 aa)
GSK3BGlycogen synthase kinase 3 beta. (442 aa)
CTNNA3Catenin alpha-3. (895 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
AKT3Non-specific serine/threonine protein kinase. (480 aa)
ELK1ETS domain-containing protein Elk-1. (427 aa)
PPP1R14BProtein phosphatase 1 regulatory subunit 14B. (122 aa)
TCF7L2Transcription factor 7 like 2. (413 aa)
SOS2Son of sevenless like protein 2. (1310 aa)
Pik3r3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
TCF7Transcription factor 7. (302 aa)
SOS1Son of sevenless like protein 1. (1289 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (388 aa)
BADBcl2 antagonist of cell death. (162 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
EGFRReceptor protein-tyrosine kinase. (1168 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (558 aa)
APC2Adenomatous polyposis coli protein 2. (1982 aa)
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (370 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
APCAdenomatous polyposis coli protein. (2857 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (165 aa)
CTNNA1Catenin alpha-1. (906 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
BRAFSerine/threonine-protein kinase B-raf. (740 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
BAXApoptosis regulator BAX. (180 aa)
EGFPro-epidermal growth factor. (1155 aa)
POLKDNA polymerase kappa. (862 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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