STRINGSTRING
Map2k2 Map2k2 MMP9 MMP9 NRAS NRAS CSDE1 CSDE1 Mdm2 Mdm2 ENSFDAP00000020777 ENSFDAP00000020777 MAPK1 MAPK1 MAPK3 MAPK3 FGFR3 FGFR3 ARAF ARAF CDH1 CDH1 MMP2 MMP2 Vegfa Vegfa THBS1 THBS1 KRAS KRAS ERBB2 ERBB2 RPS6KA5 RPS6KA5 HRAS HRAS ENSFDAP00000011804 ENSFDAP00000011804 DAPK2 DAPK2 TP53 TP53 CXCL8 CXCL8 HBEGF HBEGF MMP1 MMP1 E2F3 E2F3 DAPK1 DAPK1 H920_09786 H920_09786 MAP2K1 MAP2K1 EGFR EGFR E2F1 E2F1 RAF1 RAF1 CDKN1A CDKN1A RASSF1 RASSF1 E2F2 E2F2 CDK4 CDK4 BRAF BRAF CCND1 CCND1 ENSFDAP00000000475 ENSFDAP00000000475 UPK3A UPK3A EGF EGF RB1 RB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Map2k2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (370 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CSDE1Cold shock domain-containing protein E1. (798 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2. (504 aa)
ENSFDAP00000020777annotation not available (90 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
MAPK3Mitogen-activated protein kinase. (322 aa)
FGFR3Fibroblast growth factor receptor 3. (748 aa)
ARAFSerine/threonine-protein kinase A-Raf. (606 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (895 aa)
MMP2Matrix metallopeptidase 2. (644 aa)
VegfaVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (186 aa)
THBS1Thrombospondin-1. (1181 aa)
KRASGTPase HRas. (189 aa)
ERBB2Receptor protein-tyrosine kinase. (1212 aa)
RPS6KA5Ribosomal protein S6 kinase. (810 aa)
HRASHRas proto-oncogene, GTPase. (191 aa)
ENSFDAP00000011804annotation not available (202 aa)
DAPK2Death-associated protein kinase 3. (370 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
MMP1Interstitial collagenase. (471 aa)
E2F3Transcription factor E2F3. (334 aa)
DAPK1Death-associated protein kinase 1. (1430 aa)
H920_09786Death-associated protein kinase 3; Belongs to the protein kinase superfamily. (376 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (388 aa)
EGFRReceptor protein-tyrosine kinase. (1168 aa)
E2F1Transcription factor E2F1. (377 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (165 aa)
RASSF1Ras association domain family member 1. (339 aa)
E2F2Transcription factor E2F2. (391 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
BRAFSerine/threonine-protein kinase B-raf. (740 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
ENSFDAP00000000475annotation not available (150 aa)
UPK3AUroplakin 3A. (286 aa)
EGFPro-epidermal growth factor. (1155 aa)
RB1Retinoblastoma-associated protein. (882 aa)
Your Current Organism:
Fukomys damarensis
NCBI taxonomy Id: 885580
Other names: Coetomys damarensis, Cryptomys damarensis, Damara mole rat, Damara mole-rat, F. damarensis
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